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Recent Advances in the Study of Electrochemistry of Redox Proteins

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Book cover Trends in Bioelectroanalysis

Part of the book series: Bioanalytical Reviews ((BIOREV,volume 6))

Abstract

Redox proteins constitute a diverse class of proteins that facilitate the chemical and biological processes which are otherwise thermodynamically challenging. Efficient catalysis, diversity of biotransformation, potent redox centres and fast electron transport kinetics make these redox proteins an interesting target for electrochemical investigation for both theoretical and practical implications. The first and foremost requirement for electrochemical studies of redox proteins is to create an environment where they could interact with the electrodes either directly or via electron transport mediators. The last few years have seen a tremendous development in this field ranging from the increase in diversity of redox proteins that could possibly be studied electrochemically to their efficient immobilisation in a variety of matrices especially nanomatrices. Major advances have also been made in the area of characterisation of fabricated bioelectrodes by using different spectroscopic and microscopic techniques supplementing the electrochemical findings. This chapter will focus mainly on the aforementioned recent developments in the field of electrochemical studies of redox proteins and their applications for studies of redox mechanism or as biosensors or biofuel cells.

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Abbreviations

ACNTs:

Aligned carbon nanotubes

AFM:

Atomic force microscopy

ArO:

Arsenite oxidase

AuNPs/NWs:

Gold nanoparticles/nanowires

Az:

Azurin

CAT:

Large catalase

cbo3:

Cytochrome bo3

CcO:

Cytochrome c oxidase

ChOx:

Cholesterol oxidase

CV:

Cyclic voltammetry

CYP:

Cytochrome P450

cyt c:

Cytochrome c

D/ET:

Direct/electron transfer

DDAB:

Didodecyldimethylammonium bromide

EFCs:

Enzymatic fuel cells

EIS:

Electrochemical impedance spectroscopy

FAD:

Flavin adenine dinucleotide

FT/IR:

Fourier transform/infrared

GCE:

Glassy carbon electrode

GOx:

Glucose oxidase

Hb:

Haemoglobin

HRTEM:

High-resolution transmission electron microscopy

hSO:

Human sulphite oxidase

k s/k ET :

Electron transfer rate constant

M/SWCNTs:

Multi/single-walled carbon nanotubes

MP-11:

Microperoxidase-11

MW:

Molecular weight

NADH:

Nicotinamide adenine dinucleotide

NapAB:

Nitrate reductase

NF:

Nafion®

PANI-NTs:

Polyaniline nanotubes

PEI:

Polyethyleneimine

PFV:

Protein film voltammetry

PGE:

Pyrolytic graphite edge

QCM:

Quartz crystal microbalance

R ct :

Charge transfer resistance

SAM:

Self-assembled monolayer

SCE:

Saturated calomel electrode

SEM:

Scanning electron microscopy

SHE:

Standard hydrogen electrode

SPR:

Surface plasmon resonance

tBLMs:

Tethered bilayer membranes

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Acknowledgements

I am thankful to Alexander von Humboldt Foundation for the financial support.

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  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93053, Regensburg, Germany

    Preety Vatsyayan

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  1. Institute of Analytical Chemistry, University of Regensburg, Regensburg, Germany

    Frank-Michael Matysik

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Vatsyayan, P. (2016). Recent Advances in the Study of Electrochemistry of Redox Proteins. In: Matysik, FM. (eds) Trends in Bioelectroanalysis. Bioanalytical Reviews, vol 6. Springer, Cham. https://doi.org/10.1007/11663_2015_5001

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