Hyphenation of Electrochemistry with Mass Spectrometry for Bioanalytical Studies

  • Marija Cindric
  • Frank‐Michael MatysikEmail author
Part of the Bioanalytical Reviews book series (BIOREV, volume 1)


Hyphenation of electrochemistry (EC) and mass spectrometry (MS) is a growing research field with particular importance for bioanalytical applications. It opens the way for studying reaction mechanisms and metabolic pathways of biological compounds and drugs. Electrochemical conversion of sample molecules prior to MS analysis gives rise to short-lived intermediates and products naturally occurring in biological systems, which leads to better understanding of physiological processes. Numerous interesting and attractive studies in this field have been published so far demonstrating potential of EC–MS coupling. The combination with separation system such as liquid chromatography or capillary electrophoresis widens the scope of application providing additional information about compounds of interest. The combination of EC with liquid chromatography has been the most frequently used hyphenated system due to the simplicity of coupling to mass spectrometric detection. In terms of bioanalytical applications capillary electrophoresis offers some advantages and is a complementary technique to liquid chromatography. This review summarizes recent developments in this field from both instrumental and application perspectives. A rather new approach of coupling electrochemistry–capillary electrophoresis–mass spectrometry and its potential for bioanalysis is presented.


Bioanalysis Capillary electrophoresis Electrochemistry Liquid chromatography Mass spectrometry 









Boron-doped diamond


Capillary electrophoresis


Chain ejection model




Charge residue model


Differential electrochemical mass spectrometry


Desorption electrospray ionization


Deoxyribonucleic acid


Electrochemically assisted injection




Electrospray ionization


Fourier transform ion cyclotron resonance




Guanosine monophosphate




Inductively coupled plasma mass spectrometry


Interdigitated array


Ion evaporation model




Liquid chromatography




Matrix-assisted laser desorption/ionization


Micellar electrokinetic chromatography


Mass spectrometry


Nonaqueous capillary electrophoresis


Nuclear magnetic resonance


Ribonucleic acid


Scanning electrochemical microscopy


Screen-printed electrode













This work was supported by the European Union under Grant Agreement number 264772 (ITN CHEBANA).


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  1. 1.Institute of Analytical Chemistry, Chemo- and BiosensorsUniversity of RegensburgRegensburgGermany

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