Synthesis of Monodisperse Polymeric Nano- and Microparticles and Their Application in Bioanalysis

  • Isabel M. Perez de Vargas-SansalvadorEmail author
  • Francesco Canfarotta
  • Sergey A. Piletsky
Part of the Bioanalytical Reviews book series (BIOREV, volume 1)


The production of highly monodisperse polymer particles is very important in different fields, such as research and industry. This interest is due to their wide potential applications, ranging from drug/gene delivery to large scale separation, sensor fabrication and diagnostic applications, due to their special characteristics of uniformity in size, shape and structure. Different methods for the synthesis of monodisperse particles have been reported, but there is a necessity to find new approaches for the synthesis of functionalized monodisperse particles, in order to satisfy growing needs of industry in products with specific characteristics.

This review describes several approaches for fabrication of monodisperse polymer particles with size varying from 1 nm to 1,000 μm, highlighting problems associated with their synthesis and furnishes analysis of present and prospective areas for their applications.


Bioanalytical applications Diagnostic applications Monodisperse particles Polymeric particles 



This research was supported by the Research Executive Agency (REA) of the European Union under Grant Agreement number PITN-GA-2010-264772 (ITN CHEBANA).


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Isabel M. Perez de Vargas-Sansalvador
    • 1
    Email author
  • Francesco Canfarotta
    • 1
  • Sergey A. Piletsky
    • 1
  1. 1.Cranfield HealthCranfield UniversityCranfieldUK

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