Abstract
The paper describes a new approach to the prediction of probable biological units from protein structures obtained by means of protein crystallography. The method first employs graph-theoretical technique in order to find all possible assemblies in crystal. In second step, found assemblies are analysed for chemical stability and only stable oligomers are left as a potential solution. We also discuss theoretical models for the assessment of protein affinity and entropy loss on complex formation, used in stability analysis.
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Krissinel, E., Henrick, K. (2005). Detection of Protein Assemblies in Crystals. In: R. Berthold, M., Glen, R.C., Diederichs, K., Kohlbacher, O., Fischer, I. (eds) Computational Life Sciences. CompLife 2005. Lecture Notes in Computer Science(), vol 3695. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11560500_15
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DOI: https://doi.org/10.1007/11560500_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-29104-6
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