The Main Structural Regularities of the Sandwich Proteins
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The examination of the arrangement of the strands in beta-sandwich proteins reveals strict rules, which constrain the folding of a polypeptide chain. These structural rules allowed us to investigate the main principles of the packing of strands in the sandwich-like proteins and place severe restrictions on the number of allowed ways these proteins can fold. It was found that dissimilar sequences from different protein families and superfamilies, which share the same sandwich-like architecture, have 8 common key positions in sequences, whose residues govern the similar protein folding. These structural determinants can serve for protein classification.
KeywordsQuery Sequence Structural Determinant Structural Rule Beta Sheet trkA Receptor
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