The Main Structural Regularities of the Sandwich Proteins

  • Alexander Kister
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3692)


The examination of the arrangement of the strands in beta-sandwich proteins reveals strict rules, which constrain the folding of a polypeptide chain. These structural rules allowed us to investigate the main principles of the packing of strands in the sandwich-like proteins and place severe restrictions on the number of allowed ways these proteins can fold. It was found that dissimilar sequences from different protein families and superfamilies, which share the same sandwich-like architecture, have 8 common key positions in sequences, whose residues govern the similar protein folding. These structural determinants can serve for protein classification.


Query Sequence Structural Determinant Structural Rule Beta Sheet trkA Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Alexander Kister
    • 1
  1. 1.Department of Health Informatics, SHRPUniversity of Medicine and Dentistry of New JerseyNewarkUSA

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