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Disease Classification from Capillary Electrophoresis: Mass Spectrometry

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Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 3686))

Abstract

We investigate the possibility of using pattern recognition techniques to classify various disease types using data produced by a new form of rapid Mass Spectrometry. The data format has several advantages over other high-throughput technologies and as such could become a useful diagnostic tool. We investigate the binary and multi-class performances obtained using standard classifiers as the number of features is varied and conclude that there is potential in this technique and suggest research directions that would improve performance.

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References

  1. Alizadeh, A., Eisen, M., Davis, R., et al.: Different types of diffuse large b-cell lymphoma identified by gene expressing profiling. Nature 403, 503–511 (2000)

    Article  Google Scholar 

  2. Kolch, W., Neususs, C., Pelzing, M., Mischak, H.: Capillary electrophoresis: Mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery. Mass Spectrometry Reviews (2005) (in press)

    Google Scholar 

  3. Kaiser, T., Wittke, S., Just, I., et al.: Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use. electrophoresis 25, 2044–2055 (2004)

    Article  Google Scholar 

  4. Weissinger, E., Wittke, S., Kaiser, T., et al.: Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney International 65, 2426–2434 (2004)

    Article  Google Scholar 

  5. Lilien, R.H., Farid, H., Donald, R.: Probabilistic disease classification of expression-dependent proteomic data from mass spectrometry of human serum. Journal of Computational Biology 10, 925–946 (2003)

    Article  Google Scholar 

  6. Wagner, R., Naik, D., Pothen, A., et al.: Computational protein biomarker prediction: a case study for prostate cancer. BMC Bioinformatics 5 (2004)

    Google Scholar 

  7. Mitchell, T.: Machine Learning. McGraw-Hill, New York (1997)

    MATH  Google Scholar 

  8. Shawe-Taylor, J., Cristianini, N.: Kernel Methods for Pattern Analysis. Cambridge University Press, Cambridge (2004)

    Google Scholar 

  9. Platt, J., Cristianini, N., Shawe-Taylor, J.: Large margin DAG’s for multiclass classification. Advances in Neural Information Processing Systems 12, 547–553 (2000)

    Google Scholar 

  10. Vural, V., Dy, J.: A hierarchical method for multi-class support vector machines. In: Proceesings of the 21st International Conference on Machine Learning (2004)

    Google Scholar 

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© 2005 Springer-Verlag Berlin Heidelberg

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Rogers, S., Girolami, M., Krebs, R., Mischak, H. (2005). Disease Classification from Capillary Electrophoresis: Mass Spectrometry. In: Singh, S., Singh, M., Apte, C., Perner, P. (eds) Pattern Recognition and Data Mining. ICAPR 2005. Lecture Notes in Computer Science, vol 3686. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11551188_20

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  • DOI: https://doi.org/10.1007/11551188_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-28757-5

  • Online ISBN: 978-3-540-28758-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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