Advertisement

A Biophysical Model of Decision Making in an Antisaccade Task Through Variable Climbing Activity

  • Vassilis Cutsuridis
  • Ioannis Kahramanoglou
  • Stavros Perantonis
  • Ioannis Evdokimidis
  • Nikolaos Smyrnis
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3696)

Abstract

We present a biophysical model of saccade initiation based on competitive integration of planned and reactive cortical saccade decision signals in the intermediate layer of the superior colliculus. In the model, the variable slopes of the climbing activities of the input cortical decision signals are produced from variability in the conductances of Na + , K + , Ca2 +  activated K + , NMDA and GABA currents. These cortical decision signals are integrated in the activities of buildup neurons in the intermediate layer of the superior colliculus, whose activities grow nonlinearly towards a preset criterion level. When the level is crossed, a movement is initiated. The resultant model reproduces the unimodal distributions of saccade reaction times (SRTs) for correct antisaccades and erroneous prosaccades as well as the variability of SRTs (ranging from 80ms to 600ms) and the overall 25% of erroneous prosaccade responses in a large sample of 2006 young men performing an antisaccade task.

Keywords

Pyramidal Neuron Superior Colliculus Biophysical Model Saccade Reaction Time Antisaccade Task 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Durstewitz, D.: Self Organizing Neural Integrator Predicts Interval Times Through Climbing Activity. J. Neurosci. 23(12), 5342–5353 (2003)Google Scholar
  2. 2.
    Shampine, L.F., Reichelt, M.W.: The MATLAB ODE Suite. SIAM Journal on Scientific Computing 18, 1–22 (1997)zbMATHCrossRefMathSciNetGoogle Scholar
  3. 3.
    Evdokimidis, I., Smyrnis, N., Constantinidis, T.S., Stefanis, N.C., Avramopoulos, D., Paximadis, C., Theleritis, C., Efstratiadis, C., Kastrinakis, G., Stefanis, C.N.: The Antisaccade Task in a Sample of 2006 Young Men I. Normal Population Characteristics. Exp. Brain Res. 147, 45–52 (2002)Google Scholar
  4. 4.
    Hallett, P.R.: Primary and Secondary Saccades to Goals Defined by Instructions. Vis. Res. 18, 1279–1296 (1978)CrossRefGoogle Scholar
  5. 5.
    Hanes, D.P., Schall, J.D.: Neural Control of Voluntary Movement Initiation. Science 274, 427–430 (1996)CrossRefGoogle Scholar
  6. 6.
    Reddi, B.A.J., Carpenter, R.H.S.: The Influence of Urgency on Decision Time. Nat. Neurosci. 3, 827–831 (2000)CrossRefGoogle Scholar
  7. 7.
    Smyrnis, N., Evdokimidis, I., Stefanis, N.C., Constantinidis, T.S., Avramopoulos, D., Theleritis, C., Paximadis, C., Efstratiadis, C., Kastrinakis, G., Stefanis, C.N.: The Antisaccade Task in a Sample of 2006 Young Males II. Effects of Task Parameters. Exp. Brain Res. 147, 53–63 (2002)Google Scholar
  8. 8.
    Everling, S., Dorris, M.C., Klein, R.M., Munoz, D.P.: Role of Primate Superior Colliculus in Preparation and Execution of Anti-saccades and Prosaccades. J. Neurosci. 19(7), 2740–2754 (1998)Google Scholar
  9. 9.
    Cutsuridis, V., Smyrnis, N., Evdokimidis, I., Perantonis, S.: A Neural Model of Decision Making by the Superior Colliculus in an Antisaccade Task. Submitted to Biol. CyberneticsGoogle Scholar
  10. 10.
    Durstewitz, D., Seamans, J.K., Sejnowski, T.J.: Dopamine-Mediated Stabilization of Delay-Period Activity in a Network Model of Prefrontal Cortex. J. Neurophys. 83, 1733–1750 (2000)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Vassilis Cutsuridis
    • 1
  • Ioannis Kahramanoglou
    • 1
  • Stavros Perantonis
    • 1
  • Ioannis Evdokimidis
    • 2
  • Nikolaos Smyrnis
    • 2
    • 3
  1. 1.Computational Intelligence Laboratory, Institute of Informatics and TelecommunicationsNational Center for Scientific Research “Demokritos”AthensGR
  2. 2.Cognition and Action Group, Neurology DepartmentNational University of Athens, Aeginition HospitalAthensGR
  3. 3.Psychiatry DepartmentNational University of Athens, Aeginition HospitalAthensGR

Personalised recommendations