Abstract
Understanding protein families requires the bringing together of many different kinds of data. These families are typically derived from multiple sequence alignments. Directed mutagenesis is one of the most common means of inferring which specific amino acid or set of amino acids are important in the function of a protein. Although there are a large number publicly available, protein specific repositories, e.g., PROSITE, UniProt, and Pfam, no tools exist for experimental biologists that provide a means for managing and visualizing the curation data of the protein families they study at the individual residue level. We present the development of a novel system designed for experimental biologists, called the Curation Alignment Tool for Protein Analysis (CATPA), that allows for the efficient and effective creation, storage, management, and querying of experimentally curated protein families.
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Dalkilic, M.M. (2005). An Architecture and Application for Integrating Curation Data at the Residue Level for Proteins. In: Ludäscher, B., Raschid, L. (eds) Data Integration in the Life Sciences. DILS 2005. Lecture Notes in Computer Science(), vol 3615. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11530084_34
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DOI: https://doi.org/10.1007/11530084_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-27967-9
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