Electrophysiology and Tension Development in a Transmural Heterogeneous Model of the Visible Female Left Ventricle
Electrophysiological heterogeneity within human ventricles is mainly based on differences of ion channel characteristics inside the wall. This influences also properties of cellular tension development.
In this work, knowledge about transmural heterogeneity was transferred to an electro-mechanical heart model composed of a human model describing electrophysiology and of a model for the development of tensions. The heterogeneity was included in the cardiomyocyte model by varying ion channel kinetics and density on basis of measured data. The properties of the heterogeneous electro-mechanical model were demonstrated in a realistic model of left ventricular geometry and fiber orientation using a monodomain approach for describing electrical interaction.
This study indicated the necessity of incorporating regional heterogeneity to model human cardiac electro-mechanics with qualitative good agreement to measured data. The heterogeneity leads to a homogenization of the mechanical process due to increasing time to peak tension from epicardium towards endocardium.
KeywordsAction Potential Duration Tension Development Transmembrane Voltage Bidomain Model Visible Human Project
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