Abstract
Electrophysiological heterogeneity within human ventricles is mainly based on differences of ion channel characteristics inside the wall. This influences also properties of cellular tension development.
In this work, knowledge about transmural heterogeneity was transferred to an electro-mechanical heart model composed of a human model describing electrophysiology and of a model for the development of tensions. The heterogeneity was included in the cardiomyocyte model by varying ion channel kinetics and density on basis of measured data. The properties of the heterogeneous electro-mechanical model were demonstrated in a realistic model of left ventricular geometry and fiber orientation using a monodomain approach for describing electrical interaction.
This study indicated the necessity of incorporating regional heterogeneity to model human cardiac electro-mechanics with qualitative good agreement to measured data. The heterogeneity leads to a homogenization of the mechanical process due to increasing time to peak tension from epicardium towards endocardium.
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References
Antzelevitch, C., Yan, G., Shimizu, W., Burashnikov, A.: Electrical heterogeneity, the ECG, and cardiac arrhythmias. In: Zipes, D.P., Jalife, J. (eds.) Cardiac Electrophysiology. From Cell to Bedside, 3rd edn., pp. 222–238. W. B. Saunders Company, Philadelphia (1999)
Weiß, D.L., Seemann, G., Dössel, O.: Conditions for equal polarity of R and T wave in heterogeneous human ventricular tissue. In: Proc. BMT, vol. 49-2/1, pp. 364–365 (2004)
Ackerman, M.J.: Viewpoint: The Visible Human Project. J. Biocommunication 18, 14 (1991)
Sachse, F.B., Werner, C.D., Stenroos, M.H., Schulte, R.F., Zerfass, P., Dössel, O.: Modeling the anatomy of the human heart using the cryosection images of the Visible Female dataset. In: Proc. Third Users Conference of the National Library of Medicine’s Visible Human Project, Bethesda, USA (2000)
Sachse, F.B., Frech, R., Werner, C.D., Dössel, O.: A model based approach to assignment of myocardial fibre orientation. In: Proc. Computers in Cardiology, Hannover, vol. 26, pp. 145–148 (1999)
Streeter, D.D.: Gross morphology and fiber geometry of the heart. In: Bethesda, B. (ed.) Handbook of Physiology: The Cardiovascular System, vol. I, pp. 61–112. American Physiology Society, Hyattsville (1979)
Priebe, L., Beuckelmann, D.J.: Simulation study of cellular electric properties in heart failure. Circ. Res. 82, 1206–1223 (1998)
Hodgkin, A.L., Huxley, A.F.: A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 177, 500–544 (1952)
Seemann, G., Sachse, F.B., Weiß, D.L., Dössel, O.: Quantitative reconstruction of cardiac electromechanics in human myocardium: Regional heterogeneity. J. Cardiovasc. Electrophysiol. 14, S219–S228 (2003)
Glänzel, K., Sachse, F.B., Seemann, G., Riedel, C., Dössel, O.: Modeling force development in the sarcomere in consideration of electromechanical coupling. Biomedizinische Technik 47-1/2, 774–777 (2002)
Sachse, F.B., Glänzel, K., Seemann, G.: Modeling of protein interactions involved in cardiac tension development. Int. J. Bifurc. Chaos 13, 3561–3578 (2003)
Sachse, F.B., Seemann, G., Chaisaowong, K., Weiß, D.: Quantitative reconstruction of cardiac electromechanics in human myocardium: Assembly of electrophysiological and tension generation models. J. Cardiovasc. Electrophysiol. 14, S210–S218 (2003)
Cordeiro, J.M., Greene, L., Heilmann, C., Antzelevitch, D., Antzelevitch, C.: Transmural heterogeneity of calcium activity and mechanical function in the canine left ventricle. Am. J. Physiol. 286, H1471–H1479 (2003)
Wallis, H.L., Sears, C., Bryant, S.: Regional differences in excitation-contraction coupling in the guinea-pig left ventricle. J. Physiol. 544P., 53P–54P (2002)
LeGrice, I.J., Smaill, B.H., Chai, L.Z., Edgar, S.G., Gavin, J.B., Hunter, P.J.: Laminar structure of the heart: Ventricular myocyte arrangement and connective tissue architecture in the dog. Am. J. Physiol. 269, H571–H582 (1995)
Henriquez, C.S., Muzikant, A.L., Smoak, C.K.: Anisotropy, fiber curvature and bath loading effects on activation in thin and thick cardiac tissue preparations: Simulations in a three-dimensional bidomain model. J. Cardiovasc. Electrophysiol. 7, 424–444 (1996)
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Seemann, G., Weiß, D.L., Sachse, F.B., Dössel, O. (2005). Electrophysiology and Tension Development in a Transmural Heterogeneous Model of the Visible Female Left Ventricle. In: Frangi, A.F., Radeva, P.I., Santos, A., Hernandez, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2005. Lecture Notes in Computer Science, vol 3504. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11494621_18
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DOI: https://doi.org/10.1007/11494621_18
Publisher Name: Springer, Berlin, Heidelberg
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