Hypertrophy in Rat Virtual Left Ventricular Cells and Tissue

  • S. Kharche
  • H. Zhang
  • R. C. Clayton
  • Arun V. Holden
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3504)


Left ventricular hypertrophy induces remodeling of various ion channels and prolongs depolarization of the ventricles. We modified a model of electrical activity of rat ventricular cell by incorporating available experimental data. Hypertrophy was modeled by incorporating experimental data of changes in sodium (INa), hyperpolarizing (If), outward transient potassium (Ito) and T-type calcium currents channel kinetics (ICaT), cell size and Ca2 +  handling. In 1D simulations, a continuous increase in action potential duration (APD) and corresponding decrease in conduction velocity (CV) with subsequent beats was observed, resulting in conduction block at low values of stimulus intervals (SI), for which the simulated action potential (AP) restitution of the cell models has negative slope.


Action Potential Duration Conduction Block Stimulus Interval Ventricular Cell Transient Outward Current 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • S. Kharche
    • 1
  • H. Zhang
    • 2
  • R. C. Clayton
    • 3
  • Arun V. Holden
    • 1
  1. 1.Computational Biology Laboratory, School of Biomedical SciencesUniversity of LeedsLeedsUK
  2. 2.Department of PhysicsUMISTManchesterUK
  3. 3.Department of ComputingUniversity of SheffieldSheffieldUK

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