Modeling the Dynamics of Genetic Regulatory Networks: Continuous and Discrete Approaches

  • H de Jong
  • R Lima
Part of the Lecture Notes in Physics book series (LNP, volume 671)


A remarkable development in molecular biology today is the upscaling to the genomic level of its experimental methods. Hardly imaginable only 20 years ago, the sequencing of complete genomes has become a routine job, highly automated and executed in a quasi-industrial environment. The miniaturization of techniques for the hybridization of labeled nucleic acids in solution to DNA molecules attached to a surface has given rise to DNA microarrays, tools for measuring the level of gene expression in a massively parallel way [1]. The development of proteomic methods based on two-dimensional gel electrophoresis, mass spectrometry, and the double-hybrid system allows the identification of proteins and their interactions at a genomic scale [2].


Equilibrium Point Phase Portrait Sigma Factor Symbolic Sequence Genetic Regulatory Network 
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Authors and Affiliations

  • H de Jong
    • 1
  • R Lima
    • 2
  1. 1.Institut National de Recherche en Informatique et en Automatique (INRIA), Unité de recherche Rhône-AlpesSaint Ismier Cedex
  2. 2.Centre de Physique Théorique, CNRSCedex 09

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