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Induced Pluripotent Stem Cells in Cardiovascular Research

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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 163))

Abstract

The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSC) by overexpression of a combination of transcription factors bears the potential to spawn a wealth of new applications in both preclinical and clinical cardiovascular research. Disease modeling, which is accomplished by deriving iPSC lines from patients affected by heritable diseases and then studying the pathophysiology of the diseases in somatic cells differentiated from these patient-specific iPSC lines, is the so far most advanced of these applications. Long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia are two heart rhythm disorders that have been already successfully modeled by several groups using this approach, which will likely serve to model other mono- or polygenetic cardiovascular disorders in the future. Test systems based on cells derived from iPSC might prove beneficial to screen for novel cardiovascular drugs or unwanted drug side effects and to individualize medical therapy. The application of iPSC for cell therapy of cardiovascular disorders, albeit promising, will only become feasible if the problem of biological safety of these cells will be mastered.

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Authors and Affiliations

  1. I. Medizinische Klinik – Kardiologie, Klinikum rechts der Isar – Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany

    Daniel Sinnecker, Ralf J. Dirschinger, Alexander Goedel, Alessandra Moretti & Karl-Ludwig Laugwitz

  2. Institut für Molekulare Zellbiologie, Medizinische Fakultät, Universitätsklinikum Homburg/Saar, Universität des Saarlandes, 66421, Homburg/Saar, Germany

    Peter Lipp

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  1. Daniel Sinnecker
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  2. Ralf J. Dirschinger
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  4. Alessandra Moretti
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  5. Peter Lipp
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  6. Karl-Ludwig Laugwitz
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Correspondence to Karl-Ludwig Laugwitz .

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Editors and Affiliations

  1. Lab. Fysiologie, Katholieke Universiteit Leuven, Herestraat 49, Leuven, 3000, Belgium

    Bernd Nilius

  2. School of Medicine, Deptartment of Neurobiology, University of Pittsburgh, Fifth Avenue 3501, Pittsburgh, 15261, Pennsylvania, USA

    Susan G. Amara

  3. Medizinische Fakultät, Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München, Goethestr. 33, München, 80336, Germany

    Thomas Gudermann

  4. Abt. Neurobiologie, MPI für Biophysikalische Chemie, Am Faßberg 11, Göttingen, 37077, Germany

    Reinhard Jahn

  5. Inst. Zytobiologie und, Zytopathologie, Universität Marburg, Robert-Koch-Str. 5, Marburg, 35033, Germany

    Roland Lill

  6. , Abteilung II, Max-Planck-Institut für Herz- und Lungen, Ludwigstr. 43, Bad Nauheim, 61231, Germany

    Stefan Offermanns

  7. School of Biosciences, Cardiff University, Museum Ave., Cardiff, CF10 3US, United Kingdom

    Ole H. Petersen

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Sinnecker, D., Dirschinger, R.J., Goedel, A., Moretti, A., Lipp, P., Laugwitz, KL. (2012). Induced Pluripotent Stem Cells in Cardiovascular Research. In: Nilius, B., et al. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 163. Reviews of Physiology, Biochemistry and Pharmacology, vol 163. Springer, Berlin, Heidelberg. https://doi.org/10.1007/112_2012_6

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