Assigning functions to genes—the main challenge of the post-genomics era

  • M. JanitzEmail author
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 159)


Genome-sequencing projects yield enormous amounts of information that can lead to revolutions in our understanding of life and provide new platforms for the treatment of human diseases. However, DNA sequencing alone does not provide enough information to determine the molecular pathways of an organism in healthy and disease states. A huge number of gene products await functional characterization. Hence, there is a strong demand for technological solutions that help to assign the functions of proteins and genes. This review discusses high-throughput molecular biology methods, which promise to meet the challenges of the post-genomic era.


cDNA Microarrays Cell Array Array Format Prey Protein MyoD Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author would like to acknowledge members of his laboratory: Dominique Vanhecke, Anna Guerasimova, Andrea Fiebitz, Yu-Hui Hu, Jian-Ping Liu, Xi Cheng, Irina Girnus, and Sabine Thamm. The author also thanks the following organizations for support: the European Commission (integrated project MolTools) and the German Federal Ministry of Education and Research (grant no. 0313068, 01GS0416, 01GR0414, 31P3674).


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Max Planck Institute for Molecular GeneticsBerlinGermany

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