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Advances in Processing Chitin as a Promising Biomaterial from Ionic Liquids

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Application of Ionic Liquids in Biotechnology

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 168))

Abstract

Chitin isolated through microwave-assisted dissolution using ionic liquids is a high molecular weight (MW) polymer that can be manufactured into materials of different architectures (e.g., fibers, films, microspheres, nanostructured materials) to be used as wound care dressings, drug delivery devices, scaffolds, etc. However, because of differences from traditional isolation methods and, thus, differences in polymer length and degree of deacetylation, it could exhibit bio-related properties that differ from those of traditionally ‘pulped’ chitin. Here we present the initial assessments of bio-related chitin properties in order to provide a useful scientific basis for clinical applications: biocompatibility, cytotoxicity (intracutaneous reactivity), wound healing efficacy, histological evaluation of the wounds treated with chitin dressing, and antibacterial activity. We also provide the studies that outline potential applications of chitin as a raw polymer for preparation of biomaterials.

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Acknowledgements

The authors would like to thank the 525 Solutions, and U.S. Department of Energy (DOE) SBIR Office of Science (DE-SC0010152) for support.

Notes

RDR is an owner and president of 525 Solutions, Inc. and has a partial ownership of Mari Signum, Mid-Atlantic. JLS and OZ are employees of Mari Signum, Mid-Atlantic. RDR, JLS, and OZ are named inventors on related patent applications. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this chapter apart from those disclosed.

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Authors and Affiliations

  1. Mari Signum, Mid-Atlantic, Rockville, MD, USA

    Julia L. Shamshina & Oleksandra Zavgorodnya

  2. 525 Solutions, Inc., Tuscaloosa, AL, USA

    Robin D. Rogers

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  1. Julia L. Shamshina
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  2. Oleksandra Zavgorodnya
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  3. Robin D. Rogers
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Correspondence to Julia L. Shamshina or Robin D. Rogers .

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Editors and Affiliations

  1. Center for Research on Green Sustainable Chemistry, Graduate School of Engineering, Tottori University, Tottori, Japan

    Toshiyuki Itoh

  2. Department of Biological Engineering, College of Engineering, Inha University, Incheon, Korea (Republic of)

    Yoon-Mo Koo

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Shamshina, J.L., Zavgorodnya, O., Rogers, R.D. (2018). Advances in Processing Chitin as a Promising Biomaterial from Ionic Liquids. In: Itoh, T., Koo, YM. (eds) Application of Ionic Liquids in Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol 168. Springer, Cham. https://doi.org/10.1007/10_2018_63

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