Abstract
Protein–protein interactions are involved in many important biological processes and molecular mechanisms of disease association. Structural studies of interfacial residues in protein complexes provide information on protein–protein interactions. Characterizing protein–protein interfaces, including binding sites and allosteric changes, thus pose an imminent challenge. With special focus on protein complexes, approaches based on network theory are proposed to meet this challenge. In this review we pay attention to protein–protein interfaces from the perspective of biomolecular networks and their roles in disease. We first describe the different roles of protein complexes in disease through several structural aspects of interfaces. We then discuss some recent advances in predicting hot spots and communication pathway analysis in terms of amino acid networks. Finally, we highlight possible future aspects of this area with respect to both methodology development and applications for disease treatment.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (21203131, 31200989, and 61401068), the Natural Science Foundation of the Jiangsu Higher Education Institutions (12KJB180014), and the China Postdoctoral Science Foundation (2016M590495), Preproposal Research Fund (PRF4/2558 and PRF-PII/59), Faculty of Science, Kasetsart University.
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Hu, G., Xiao, F., Li, Y., Li, Y., Vongsangnak, W. (2016). Protein–Protein Interface and Disease: Perspective from Biomolecular Networks. In: Nookaew, I. (eds) Network Biology. Advances in Biochemical Engineering/Biotechnology, vol 160. Springer, Cham. https://doi.org/10.1007/10_2016_40
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DOI: https://doi.org/10.1007/10_2016_40
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