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Advances and Practices of Bioprocess Scale-up

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Bioreactor Engineering Research and Industrial Applications II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 152))

Abstract

This chapter addresses the update progress in bioprocess engineering. In addition to an overview of the theory of multi-scale analysis for fermentation process, examples of scale-up practice combining microbial physiological parameters with bioreactor fluid dynamics are also described. Furthermore, the methodology for process optimization and bioreactor scale-up by integrating fluid dynamics with biokinetics is highlighted. In addition to a short review of the heterogeneous environment in large-scale bioreactor and its effect, a scale-down strategy for investigating this issue is addressed. Mathematical models and simulation methodology for integrating flow field in the reactor and microbial kinetics response are described. Finally, a comprehensive discussion on the advantages and challenges of the model-driven scale-up method is given at the end of this chapter.

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Acknowledgment

Financial support of State Key Development Program of Basic Research of China (973 Program, Grant No. 2013CB733600), NWO-MoST Joint Program (2013DFG32630), National High Technology Research and Development Program of China (863 Program, Grant No. 2012AA021201 and 2014AA021701), and China Ministry of Science and Technology under Contract (Grant No. 2012BAI44G00) are gratefully acknowledged.

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Authors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

    Jianye Xia, Guan Wang, Jihan Lin, Yonghong Wang, Ju Chu, Yingping Zhuang & Siliang Zhang

Authors
  1. Jianye Xia
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  2. Guan Wang
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  3. Jihan Lin
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  4. Yonghong Wang
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  5. Ju Chu
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  6. Yingping Zhuang
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  7. Siliang Zhang
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Corresponding author

Correspondence to Siliang Zhang .

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Editors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China

    Jie Bao

  2. State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China

    Qin Ye

  3. School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Jian-Jiang Zhong

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Xia, J. et al. (2015). Advances and Practices of Bioprocess Scale-up. In: Bao, J., Ye, Q., Zhong, JJ. (eds) Bioreactor Engineering Research and Industrial Applications II. Advances in Biochemical Engineering/Biotechnology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2014_293

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