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Biodiversity in Production of Antibiotics and Other Bioactive Compounds

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Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 147)

Abstract

Microbes continue to play a highly considerable role in the drug discovery and development process. Nevertheless, the number of new chemical entities (NCEs) of microbial origin that has been approved by the Food and Drug Administration (FDA) has been reduced in the past decade. This scarcity can be partly attributed to the redundancy in the discovered molecules from microbial isolates, which are isolated from common terrestrial ecological units. However, this situation can be partly overcome by exploring rarely exploited ecological niches as the source of microbes, which reduces the chances of isolating compounds similar to existing ones. The use of modern and advanced isolation techniques, modification of the existing fermentation methods, genetic modifications to induce expression of silent genes, analytical tools for the detection and identification of new chemical entities, use of polymers in fermentation to enhance yield of fermented compounds, and so on, have all aided in enhancing the frequency of acquiring novel compounds. These compounds are representative of numerous classes of diverse compounds. Thus, compounds of microbial origin and their analogues undergoing clinical trials continue to demonstrate the importance of compounds from microbial sources in modern drug discovery.

Graphical Abstract

Keywords

Actinomycetes Fungi Myxobacteria Biodiversity Antibiotics Antitumor Anticancer 

Notes

Acknowledgments

The authors wish to thank the management of Piramal Enterprises Limited for their encouragement in the dissemination of science, which deals with the discovery of new drugs for alleviating disease on this planet. Very special thanks to Dr. P. D. Mishra, Head, Natural Product Chemistry Division-Piramal Enterprises Limited for his help in providing the necessary structures of requested compounds.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Piramal Enterprises LimitedMumbaiIndia
  2. 2.Karmic Lifesciences Inc.MumbaiIndia

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