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Utility of Insects for Studying Human Pathogens and Evaluating New Antimicrobial Agents

  • Yan WangEmail author
  • De-Dong Li
  • Yuan-Ying Jiang
  • Eleftherios MylonakisEmail author
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 135)

Abstract

Insect models, such as Galleria mellonella and Drosophila melanogaster have significant ethical, logistical, and economic advantages over mammalian models for the studies of infectious diseases. Using these models, various pathogenic microbes have been studied and many novel virulence genes have been identified. Notably, because insects are susceptible to a wide variety of human pathogens and have immune responses similar to those of mammals, they offer the opportunity to understand innate immune responses against human pathogens better. It is important to note that insect pathosystems have also offered a simple strategy to evaluate the efficacy and toxicity of many antimicrobial agents. Overall, insect models provide a rapid, inexpensive, and reliable way as complementary hosts to conventional vertebrate animal models to study pathogenesis and antimicrobial agents.

Keywords

Antimicrobial efficacy Drosophila Galleria Infection Insect Pathogen Pathogenesis 

Abbreviations

MRSA

Methicillin-resistant Staphylococcus aureus

RNAi

RNA interference

Notes

Acknowledgments

This work was supported by the National Institutes of Health through an R01 award (AI075286) and an R21 award (AI070569) to Eleftherios Mylonakis, and National Natural Science Foundation of China (81273558, 81072678) to Yan Wang.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.New Drug Research and Development Center, School of PharmacySecond Military Medical UniversityShanghaiChina
  2. 2.Division of Infectious Diseases, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.Division of Infectious Diseases, Rhode Island HospitalWarren Alpert Medical School of Brown UniversityRhode IslandUSA

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