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An Advanced Monitoring Platform for Rational Design of Recombinant Processes

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Measurement, Monitoring, Modelling and Control of Bioprocesses

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 132))

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Abbreviations

ANN:

Artificial neural networks

amu:

Atomic mass unit

CER:

Carbon dioxide evolution rate

CRP:

Catabolite regulation protein

CDM:

Cell dry mass

cAMP:

Cyclic adenosine monophosphate

DC:

Dead cells

EMA:

European medicines agency

GFP:

Green fluorescent protein

ppGpp:

Guanosine tetraphosphate

HCDC:

High-cell-density cultivation

ICH:

International conference on harmonisation

IPTG:

Isopropyl β-D-thiogalactopyranoside

MVDA:

Multivariate data analysis

MS:

Mass spectrometry

NIR:

Near-infrared

OUR:

Oxygen uptake rate

ppmV:

Parts per million volume

pptV:

Parts per trillion volume

PLS:

Partial least squares

PCN:

Plasmid copy number

PTR-MS:

Proton transfer reaction mass spectrometry

QbD:

Quality by design

RBF-NN:

Radial basis function neural network

RT-PCR:

Real-time polymerase chain reaction

RQ:

Respiration quotient

RMSEP:

Root-mean-square error of prediction

SOD:

Superoxide dismutase

TCN:

Total cell number

FDA:

US food and drug administration

VOC:

Volatile organic compound

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Authors and Affiliations

  1. Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18/B, A-1190, Vienna, Austria

    G. Striedner & K. Bayer

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  1. G. Striedner
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  2. K. Bayer
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Correspondence to G. Striedner .

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Editors and Affiliations

  1. , Division of Biotechnology, Linköping University, Campus, Linköping, 581 83, Sweden

    Carl-Fredrik Mandenius

  2. Dept.Biochemival Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom

    Nigel J Titchener-Hooker

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Striedner, G., Bayer, K. (2012). An Advanced Monitoring Platform for Rational Design of Recombinant Processes. In: Mandenius, CF., Titchener-Hooker, N. (eds) Measurement, Monitoring, Modelling and Control of Bioprocesses. Advances in Biochemical Engineering/Biotechnology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_169

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