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Urine as a Source of Stem Cells

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Mesenchymal Stem Cells - Basics and Clinical Application I

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 129))

Abstract

Traditionally, clinicians and researchers have relied on a skin biopsy or blood extraction as relatively accessible supplies for in vitro cell expansion and biological studies. Perhaps surprisingly, limited attention has been given to a totally noninvasive source, urine, which eliminates the discomfort associated with other procedures. This may arise from the perception that urine is merely a body waste. Yet, the analysis of urine is a longstanding fundamental test for diagnostic purposes and nowadays there is growing interest in using urine for detecting biomarkers. In addition, recent work including ours reinforces the idea that urine contains a variety of viable cell types with relevant applications. In this review, we describe those cell types and their potential uses.

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Abbreviations

EGF:

Epidermal growth factor

ESCs:

Embryonic stem cells

iPSCs:

Induced pluripotent stem cells

USCs:

Urine-derived stem cells

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Acknowledgments

This work was funded by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020106), the National Natural Science Foundation of China (31071309), and the Ministry of Science and Technology of China 973 program (2011CB965200) to MAE.

Author information

Authors and Affiliations

  1. Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530, China

    Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Duanqing Pei & Miguel A. Esteban

  2. Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530, China

    Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Duanqing Pei & Miguel A. Esteban

  3. Aging and Immortalization Research, Department of Biotechnology, University of Natural Resources and Life Sciences, 1190, Vienna, Austria

    Johannes Grillari & Regina Grillari-Voglauer

  4. Evercyte GmbH, 1190, Vienna, Austria

    Johannes Grillari & Regina Grillari-Voglauer

  5. Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China

    Hung-Fat Tse

  6. Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong, Hong Kong, China

    Hung-Fat Tse & Miguel A. Esteban

  7. Guangzhou Institutes of Biomedicine and Health, Guangzhou, China

    Hung-Fat Tse & Miguel A. Esteban

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  1. Christina Benda
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Corresponding author

Correspondence to Christina Benda .

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Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Carl-Neubergstr. 1, Hannover, 30625, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena, Modena, Italy

    Massimo Dominici

  3. Klinik für Frauenheilkunde und Geburtshi, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Ralf Hass

  4. Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, Wien, 1190, Austria

    Cornelia Kasper

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© 2012 Springer-Verlag Berlin Heidelberg

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Benda, C. et al. (2012). Urine as a Source of Stem Cells. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application I. Advances in Biochemical Engineering/Biotechnology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_157

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