Skip to main content
SpringerLink
Log in

Mesenchymal Stem Cell Therapy and Lung Diseases

  • Chapter
  • First Online:
Mesenchymal Stem Cells - Basics and Clinical Application II

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 130))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

MSC:

Mesenchymal stem cell

CFU-F:

Colony-forming unit fibroblast

AEC:

Alveolar epithelial cell

AECI:

Type I alveolar epithelial cells

AECII:

Type II alveolar epithelial cells

VEGF:

Vascular endothelial growth factor

eNOS:

Endothelial nitric oxide synthase

ALI:

Acute lung injury

ARDS:

Acute respiratory distress syndrome

LPS:

Lipopolysaccharide

KGF:

Keratinocyte growth factor

COPD:

Chronic obstructive pulmonary disease

CF:

Cystic fibrosis

CFTR:

Cystic fibrosis transmembrane conductance regulator

IPF:

Idiopathic pulmonary fibrosis

SP-C:

Surfactant Protein-C

HSCs:

Haematopoietic stem cells

PH:

Pulmonary hypertension

References

  1. Abe S, Boyer C, Liu X, Wen FQ, Kobayashi T, Fang Q, Wang X, Hashimoto M, Sharp JG, Rennard SI (2004) Cells derived from the circulation contribute to the repair of lung injury. Am J Respir Crit Care Med 170(11):1158–1163

    Google Scholar 

  2. Abreu SC, Antunes MA, Pelosi P, Morales MM, Rocco PR (2011) Mechanisms of cellular therapy in respiratory diseases. Intensive Care Med 37(9):1421–1431

    Google Scholar 

  3. Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM (2009) Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS ONE 4(11):e8013

    Google Scholar 

  4. Anderson WR, Thielen K (1992) Correlative study of adult respiratory distress syndrome by light, scanning, and transmission electron microscopy. Ultrastruct Pathol 16(6):615–628

    CAS  Google Scholar 

  5. Antoniou KM, Papadaki HA, Soufla G, Kastrinaki MC, Damianaki A, Koutala H, Spandidos DA, Siafakas NM (2010) Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in idiopathic pulmonary fibrosis (IPF). Respir Med 104(10):1535–1542

    Google Scholar 

  6. Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA 3rd, Lansdorp PM, Greider CW, Loyd JE (2007) Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356(13):1317–1326

    CAS  Google Scholar 

  7. Arnhold S, Absenger Y, Klein H, Addicks K, Schraermeyer U (2007) Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse. Graefes Arch Clin Exp Ophthalmol 245(3):414–422

    CAS  Google Scholar 

  8. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. The Lancet Crit Care Resusc 7(1):60–61

    Google Scholar 

  9. Baber SR, Deng W, Master RG, Bunnell BA, Taylor BK, Murthy SN, Hyman AL, Kadowitz PJ (2007) Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol 292(2):120–128

    Google Scholar 

  10. Bachofen M, Bachofen H (1979) Follow-up of severe adult respiratory distress syndrome. Schweiz Med Wochenschr 109(50):1982–1989

    CAS  Google Scholar 

  11. Bachofen M, Weibel ER (1977) Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am Rev Respir Dis 116(4):589–615

    CAS  Google Scholar 

  12. Baksh D, Song L, Tuan RS (2004) Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8(3):301–316

    CAS  Google Scholar 

  13. Baksh D, Yao R, Tuan RS (2007) Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25(6):1384–1392

    CAS  Google Scholar 

  14. Barbas-Filho JV, Ferreira MA, Sesso A, Kairalla RA, Carvalho CR, Capelozzi VL (2001) Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP). J Clin Pathol 54(2):132–138

    CAS  Google Scholar 

  15. Barlow S, Brooke G, Chatterjee K, Price G, Pelekanos R, Rossetti T, Doody M, Venter D, Pain S, Gilshenan K, Atkinson K (2008) Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev 17(6):1095–1107

    CAS  Google Scholar 

  16. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114(6):763–776

    CAS  Google Scholar 

  17. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R (1994) The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149(3):818–824

    CAS  Google Scholar 

  18. Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL (2006) Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 290(6):196–203

    Google Scholar 

  19. Bianco P, Robey PG, Simmons PJ (2008) Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2(4):313–319

    CAS  Google Scholar 

  20. Bjoraker JA, Ryu JH, Edwin MK, Myers JL, Tazelaar HD, Schroeder DR, Offord KP (1998) Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 157(1):199–203

    CAS  Google Scholar 

  21. Bozelka BE, Sestini P, Gaumer HR, Hammad Y, Heather CJ, Salvaggio JE (1983) A murine model of asbestosis. Am J Pathol 112(3):326–337

    CAS  Google Scholar 

  22. Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS (2006) Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proc Natl Acad Sci U S A 103(8):2965–2970

    CAS  Google Scholar 

  23. Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS (2006) Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells 24(10):2299–2308

    CAS  Google Scholar 

  24. Burdon TJ, Paul A, Noiseux N, Prakash S, Shum-Tim D (2011) Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res. doi:10.1155/2011/207326

    Google Scholar 

  25. Chamberlain G, Fox J, Ashton B, Middleton J (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25(11):2739–2749

    CAS  Google Scholar 

  26. Chang YS, Oh W, Choi SJ, Sung DK, Kim SY, Choi EY, Kang S, Jin HJ, Yang YS, Park WS (2009) Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant 18(8): 869-886

    Google Scholar 

  27. Chapman HA, Allen CL, Stone OL (1986) Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease. Am Rev Respir Dis 133(3):437–443

    CAS  Google Scholar 

  28. Clark BR, Jamieson C, Keating A (1997) Human long-term bone marrow culture. Methods Mol Biol 75:249–256

    CAS  Google Scholar 

  29. Conconi MT, Burra P, Di Liddo R, Calore C, Turetta M, Bellini S, Bo P, Nussdorfer GG, Parnigotto PP (2006) CD105(+) cells from Wharton’s jelly show in vitro and in vivo myogenic differentiative potential. Int J Mol Med 18(6):1089–1096

    CAS  Google Scholar 

  30. Conese M, Ascenzioni F, Boyd AC, Coutelle C, De Fino I, De Smedt S, Rejman J, Rosenecker J, Schindelhauer D, Scholte BJ (2011) Gene and cell therapy for cystic fibrosis: from bench to bedside. J Cyst Fibros 10(2):114–128

    Google Scholar 

  31. Corrin B, Dewar A, Rodriguez-Roisin R, Turner-Warwick M (1985) Fine structural changes in cryptogenic fibrosing alveolitis and asbestosis. J Pathol 147(2):107–119

    CAS  Google Scholar 

  32. Danchuk S, Joni H, Hossain FF, Sorge RF, Ramsey A, Ryan W, Sullivan DE (2010) Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-alpha-induced protein 6. Stem Cell Res Ther 2(3):27–42

    Google Scholar 

  33. Davis GS, Leslie KO, Hemenway DR (1998) Silicosis in mice: effects of dose, time, and genetic strain. J Environ Pathol Toxicol Oncol 17(2):81–97

    CAS  Google Scholar 

  34. Deb A, Wang S, Skelding KA, Miller D, Simper D, Caplice NM (2003) Bone marrow-derived cardiomyocytes are present in adult human heart: a study of gender-mismatched bone marrow transplantation patients. Circulation 107(9):1247–1249

    Google Scholar 

  35. Deboeck G, Scoditti C, Huez S, Luc Vachiery J, Lamotte M, Sharples L, Melot C, Naeije R (2012) Exercise to predict outcome in idiopathic vs associated pulmonary arterial hypertension. Eur Respir J. doi:10.1183/09031936.00217911

    Google Scholar 

  36. Delorme B, Ringe J, Pontikoglou C, Gaillard J, Langonne A, Sensebe L, Noel D, Jorgensen C, Haupl T, Charbord P (2009) Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity. Stem Cells 27(5):1142–1151

    CAS  Google Scholar 

  37. Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C (2004) Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 113(12):1701–1710

    CAS  Google Scholar 

  38. Diaz de Leon A, Cronkhite JT, Katzenstein AL, Godwin JD, Raghu G, Glazer CS, Rosenblatt RL, Girod CE, Garrity ER, Xing C, Garcia CK (2010) Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS ONE 5(5):e10680

    Google Scholar 

  39. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8(4):315–317

    CAS  Google Scholar 

  40. Ennis J, Sarugaser R, Gomez A, Baksh D, Davies JE (2008) Isolation, characterization, and differentiation of human umbilical cord perivascular cells (HUCPVCs). Methods Cell Biol 86:121–136

    CAS  Google Scholar 

  41. Fares WH, Trow TK (2012) Targeted approaches to the treatment of pulmonary hypertension. Ther Adv Respir Dis. doi:10.1177/1753465812441849

    Google Scholar 

  42. Farmen SL, Karp PH, Ng P, Palmer DJ, Koehler DR, Hu J, Beaudet AL, Zabner J, Welsh MJ (2005) Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl− transport and overexpression can generate basolateral CFTR. Am J Physiol Lung Cell Mol Physiol 289(6):1123–1130

    Google Scholar 

  43. Fischer UM, Harting MT, Jimenez F, Monzon-Posadas WO, Xue H, Savitz SI, Laine GA, Cox CS Jr (2009) Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 18(5):683–692

    CAS  Google Scholar 

  44. Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3(4):393–403

    CAS  Google Scholar 

  45. Furlani D, Ugurlucan M, Ong L, Bieback K, Pittermann E, Westien I, Wang W, Yerebakan C, Li W, Gaebel R, Li RK, Vollmar B, Steinhoff G, Ma N (2009) Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy. Microvasc Res 77(3):370–376

    CAS  Google Scholar 

  46. Gharaee-Kermani M, Gyetko MR, Hu B, Phan SH (2007) New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy. Pharm Res 24(5):819–841

    CAS  Google Scholar 

  47. Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signalling and therapy. Circ Res 103(11):1204–1219

    CAS  Google Scholar 

  48. Goldman MJ, Yang Y, Wilson JM (1995) Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. Nat Genet 9(2):126–131

    CAS  Google Scholar 

  49. Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J, Tata LJ (2006) Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax 61(11):980–985

    CAS  Google Scholar 

  50. Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, Gimble JM (2006) Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. J Cell Physiol 206(1):229–237

    CAS  Google Scholar 

  51. Guo J, Yi ES, Havill AM, Sarosi I, Whitcomb L, Yin S, Middleton SC, Piguet P, Ulich TR (1998) Intravenous keratinocyte growth factor protects against experimental pulmonary injury. Am J Physiol 275(4):800–805

    Google Scholar 

  52. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA (2007) Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179(3):1855–1863

    CAS  Google Scholar 

  53. Harrison JH Jr, Lazo JS (1987) High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J Pharmacol Exp Ther 243(3):1185–1194

    CAS  Google Scholar 

  54. Haston CK, Travis EL (1997) Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Cancer Res 57(23):5286–5291

    CAS  Google Scholar 

  55. Hayes M, Curley G, Laffey JG (2012) Mesenchymal stem cells—a promising therapy for acute respiratory distress syndrome. Med Rep 4:2

    Google Scholar 

  56. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A, International Society for Cellular Therapy (2005) Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 7(5):393–395

    CAS  Google Scholar 

  57. Javazon EH, Beggs KJ, Flake AW (2004) Mesenchymal stem cells: paradoxes of passaging. Exp Hematol 32(5):414–425

    CAS  Google Scholar 

  58. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57(1):43–66

    Google Scholar 

  59. Johnson LG, Boyles SE, Wilson J, Boucher RC (1995) Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. J Clin Invest 95(3):1377–1382

    CAS  Google Scholar 

  60. Johnson LG, Olsen JC, Sarkadi B, Moore KL, Swanstrom R, Boucher RC (1992) Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat Genet 2(1):21–25

    CAS  Google Scholar 

  61. Kanki-Horimoto S, Horimoto H, Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T (2006) Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 114(1):181–185

    Google Scholar 

  62. Kern SF, Eichler HF, Stoeve JF, Kluter HF, Bieback K (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem cells 24(5): 1294–1301

    CAS  Google Scholar 

  63. Kondo T, Hayashi M, Takeshita K, Numaguchi Y, Kobayashi K, Iino S, Inden Y, Murohara T (2004) Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 24(8):1442–1447

    CAS  Google Scholar 

  64. Kotani I, Sato A, Hayakawa H, Urano T, Takada Y, Takada A (1995) Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis. Thromb Res 77(6):493–504

    CAS  Google Scholar 

  65. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A (2001) Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128(24):5181–5188

    CAS  Google Scholar 

  66. Kovacic JC, Muller DW, Harvey R, Graham RM (2005) Update on the use of stem cells for cardiac disease. Intern Med J 35(6):348–356

    CAS  Google Scholar 

  67. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA (2010) Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 28(12):2229–2238

    CAS  Google Scholar 

  68. Kuhbier JW, Weyand B, Radtke C, Vogt PM, Kasper C, Reimers K (2010) Isolation, characterization, differentiation, and application of adipose-derived stem cells. Adv Biochem Eng Biotechnol 123:55–105

    CAS  Google Scholar 

  69. Kuwano K, Miyazaki H, Hagimoto N, Kawasaki M, Fujita M, Kunitake R, Kaneko Y, Hara N (1999) The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am J Respir Cell Mol Biol 20(1):53–60

    CAS  Google Scholar 

  70. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA (2009) Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A 106(38):16357–16362

    CAS  Google Scholar 

  71. Loi R, Beckett T, Goncz KK, Suratt BT, Weiss DJ (2006) Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med 173(2):171–179

    CAS  Google Scholar 

  72. Ma N, Gai H, Mei J, Ding FB, Bao CR, Nguyen DM, Zhong H (2011) Bone marrow mesenchymal stem cells can differentiate into type II alveolar epithelial cells in vitro. Cell Biol Int 35(12):1261–1266

    CAS  Google Scholar 

  73. Macchiarini P, Jungebluth P, Go T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP, Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA (2008) Clinical transplantation of a tissue-engineered airway. Lancet 372(9655):2023–2030

    Google Scholar 

  74. Madonna R, Geng YJ, De Caterina R (2009) Adipose tissue-derived stem cells: characterization and potential for cardiovascular repair. Arterioscler Thromb Vasc Biol 29(11):1723–1729

    CAS  Google Scholar 

  75. Mall MF, Bleich MF, Greger RF, Schreiber RF, Kunzelmann K (1998) The amiloride-inhibitable Na+conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. J Clin Investig 102(1):15–21

    CAS  Google Scholar 

  76. Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma (GINA) Program (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59(5):469–478

    Google Scholar 

  77. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95(7):1005–1015

    CAS  Google Scholar 

  78. Mei SHJ, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ (2007) Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 4(9):e269–e269

    Google Scholar 

  79. Moore BB, Hogaboam CM (2008) Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294(2):L152–L160

    CAS  Google Scholar 

  80. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G (2004) Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15(7):1794–1804

    Google Scholar 

  81. Nakagawa H, Akita S, Fukui M, Fujii T, Akino K (2005) Human mesenchymal stem cells successfully improve skin-substitute wound healing. Br J Dermatol 153(1):29–36

    CAS  Google Scholar 

  82. Nash JR, McLaughlin PJ, Butcher D, Corrin B (1993) Expression of tumour necrosis factor-alpha in cryptogenic fibrosing alveolitis. Histopathology 22(4):343–347

    CAS  Google Scholar 

  83. Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42–49

    CAS  Google Scholar 

  84. Nemeth K, Keane-Myers A, Brown JM, Metcalfe DD, Gorham JD, Bundoc VG, Hodges MG, Jelinek I, Madala S, Karpati S, Mezey E (2010) Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U SA 107(12):5652–5657

    CAS  Google Scholar 

  85. Nichols JE, Cortiella J (2008) Engineering of a complex organ: progress toward development of a tissue-engineered lung. Proc Am Thorac Soc 5(6):723–730

    Google Scholar 

  86. Oedayrajsingh-Varma MJ, van Ham SM, Knippenberg M, Helder MN, Klein-Nulend J, Schouten TE, Ritt MJ, van Milligen FJ (2006) Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 8(2):166–177

    CAS  Google Scholar 

  87. Olson AL, Swigris JJ, Lezotte DC, Norris JM, Wilson CG, Brown KK (2007) Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am J Respir Crit Care Med 176(3):277–284

    Google Scholar 

  88. Omori K, Tada Y, Suzuki T, Nomoto Y, Matsuzuka T, Kobayashi K, Nakamura T, Kanemaru S, Yamashita M, Asato R (2008) Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea. Ann Otol Rhinol Laryngol 117(9):673–678

    Google Scholar 

  89. Omori K, Nakamura T, Kanemaru S, Magrufov A, Yamashita M, Shimizu Y (2008) In situ tissue engineering of the cricoid and trachea in a canine model. Ann Otol Rhinol Laryngol 117(8):609–613

    Google Scholar 

  90. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG (2007) Interleukin 1 receptor antagonist mediates the anti-inflammatory and anti-fibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A 104(26):11002–11007

    CAS  Google Scholar 

  91. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG (2003) Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 100(14):8407–8411

    CAS  Google Scholar 

  92. Palange P, Testa U, Huertas A, Calabro L, Antonucci R, Petrucci E, Pelosi E, Pasquini L, Satta A, Morici G, Vignola MA, Bonsignore MR (2006) Circulating haemopoietic and endothelial progenitor cells are decreased in COPD. Eur Respir J 27(3):529–541

    CAS  Google Scholar 

  93. Panos RJ, Rubin JS, Csaky KG, Aaronson SA, Mason RJ (1993) Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 92(2):969–977

    CAS  Google Scholar 

  94. Parolini O, Alviano F, Bagnara GP, Bilic G, Buhring HJ, Evangelista M, Hennerbichler S, Liu B, Magatti M, Mao N, Miki T, Marongiu F, Nakajima H, Nikaido T, Portmann-Lanz CB, Sankar V, Soncini M, Stadler G, Surbek D, Takahashi TA, Redl H, Sakuragawa N, Wolbank S, Zeisberger S, Zisch A, Strom SC (2008) Concise review: isolation and characterization of cells from human term placenta: outcome of the first international workshop on placenta derived stem cells. Stem Cells 26(2):300–311

    Google Scholar 

  95. Patt HM, Maloney MA (1975) Bone marrow regeneration after local injury: a review. Exp Hematol 3(2):135–148

    CAS  Google Scholar 

  96. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147

    CAS  Google Scholar 

  97. Rabinovitch M (2008) Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118(7):2372–2379

    CAS  Google Scholar 

  98. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ, ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis (2011) An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183(6):788–824

    Google Scholar 

  99. Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G (2006) Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 174(7):810–816

    Google Scholar 

  100. Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL (2005) Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33(2):145–152

    CAS  Google Scholar 

  101. Rubenfeld GD (2003) Epidemiology of acute lung injury. Crit Care Med 31(4):276–284

    Google Scholar 

  102. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685–1693

    CAS  Google Scholar 

  103. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, Bianco P (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131(2):324–336

    CAS  Google Scholar 

  104. Salazar KD, Lankford SM, Brody AR (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297(5):1002–1011

    Google Scholar 

  105. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, Sato T, Miyanishi K, Takayama T, Takahashi M, Takimoto R, Iyama S, Matsunaga T, Ohtani S, Matsuura A, Hamada H, Niitsu Y (2005) Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 106(2):756–763

    CAS  Google Scholar 

  106. Schaffler A, Buchler C (2007) Concise review: adipose tissue-derived stromal cells––basic and clinical implications for novel cell-based therapies. Stem Cells 25(4):818–827

    Google Scholar 

  107. Secco M, Zucconi E, Vieira NM, Fogaca LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri AR, Zatz M (2008) Multipotent stem cells from umbilical cord: cord is richer than blood. Stem Cells 26(1):146–150

    CAS  Google Scholar 

  108. Selman M, Carrillo G, Salas J, Padilla RP, Perez-Chavira R, Sansores R, Chapela R (1998) Colchicine, D-penicillamine, and prednisone in the treatment of idiopathic pulmonary fibrosis: a controlled clinical trial. Chest 114(2):507–512

    CAS  Google Scholar 

  109. Selman M, King TE, Pardo A, American Thoracic Society, European Respiratory Society and American College of Chest Physicians (2001) Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134(2):136–151

    CAS  Google Scholar 

  110. Selman M, Pardo A (2002) Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder. Respir Res 3:31. doi:10.1186/rr175

  111. Sheppard DN, Welsh MJ (1999) Structure and function of the CFTR chloride channel. Physiol Rev 79(1):23–45

    Google Scholar 

  112. Sordi V, Malosio ML, Marchesi F, Mercalli A, Melzi R, Giordano T, Belmonte N, Ferrari G, Leone BE, Bertuzzi F, Zerbini G, Allavena P, Bonifacio E, Piemonti L (2005) Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 106(2):419–427

    CAS  Google Scholar 

  113. Spencer HF, Jaffe A (2004) The potential for stem cell therapy in cystic fibrosis. J R Soc Med 97(44):52–56

    Google Scholar 

  114. Strieter RM (2005) Pathogenesis and natural history of usual interstitial pneumonia: the whole story or the last chapter of a long novel. Chest 128(5):526–532

    Google Scholar 

  115. Strobel ES, Gay RE, Greenberg PL (1986) Characterization of the in vitro stromal microenvironment of human bone marrow. Int J Cell Cloning 4(5):341–356

    CAS  Google Scholar 

  116. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC (1995) CFTR as a cAMP-dependent regulator of sodium channels. Science 269(5225):847–850

    CAS  Google Scholar 

  117. Sueblinvong V, Weiss DJ (2010) Stem cells and cell therapy approaches in lung biology and diseases. Transl Res 156(3):188–205

    CAS  Google Scholar 

  118. Suzuki G, Iyer V, Lee TC, Canty JM Jr (2011) Autologous mesenchymal stem cells mobilize cKit+ and CD133+ bone marrow progenitor cells and improve regional function in hibernating myocardium. Circ Res 109(9):1044–1054

    CAS  Google Scholar 

  119. Tamagawa T, Oi S, Ishiwata I, Ishikawa H, Nakamura Y (2007) Differentiation of mesenchymal cells derived from human amniotic membranes into hepatocyte-like cells in vitro. Hum Cell 20(3):77–84

    Google Scholar 

  120. Thomas AQ, Lane K, Phillips J, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE (2002) Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165(9):1322–1328

    Google Scholar 

  121. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD (2002) Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105(1):93–98

    Google Scholar 

  122. Tomei AA, Boschetti F, Gervaso F, Swartz MA (2009) 3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support. Biotechnol Bioeng 103(1):217–225

    CAS  Google Scholar 

  123. Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK (2007) Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A 104(18):7552–7557

    CAS  Google Scholar 

  124. Tzouvelekis A, Koliakos G, Ntolios P, Baira I, Bouros E, Oikonomou A, Zissimopoulos A, Kolios G, Kakagia D, Paspaliaris V, Kotsianidis I, Froudarakis M, Bouros D (2011) Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal. J Transl Med 9:182–191

    Google Scholar 

  125. Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A, Selman M (1998) Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol 275(6):1192–1199

    Google Scholar 

  126. Walker NM, Badri LN, Wadhwa A, Wettlaufer S, Peters-Golden M, Lama VN (2012) Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts. Am J Respir Crit Care Med 185(1):77–84

    CAS  Google Scholar 

  127. Wan C, He Q, Li G (2006) Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone defect model. J Orthop Res 24(4):610–618

    Google Scholar 

  128. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342(18):1334–1349

    CAS  Google Scholar 

  129. Weissman IL (2000) Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 287(5457):1442–1446

    CAS  Google Scholar 

  130. Wine JJ, Joo NS (2004) Submucosal glands and airway defense. Proc Am Thorac Soc 1(1):47–53

    CAS  Google Scholar 

  131. Yan X, Liu Y, Han Q, Jia M, Liao L, Qi M, Zhao RC (2007) Injured microenvironment directly guides the differentiation of engrafted Flk-1(+) mesenchymal stem cell in lung. Exp Hematol 35(9):1466–1475

    CAS  Google Scholar 

  132. Yano T, Mason RJ, Pan T, Deterding RR, Nielsen LD, Shannon JM (2000) KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung. Am J Physiol Lung Cell Mol Physiol 279(6):1146–1158

    Google Scholar 

  133. Yuhgetsu H, Ohno Y, Funaguchi N, Asai T, Sawada M, Takemura G, Minatoguchi S, Fujiwara H, Fujiwara T (2006) Beneficial effects of autologous bone marrow mononuclear cell transplantation against elastase-induced emphysema in rabbits. Exp Lung Res 32(9):413–426

    Google Scholar 

  134. Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, Rosenquist GL, Louie S (2010) Geoepidemiology of COPD and idiopathic pulmonary fibrosis. J Autoimmun 34(3):327–338

    Google Scholar 

  135. Zeng R, Wang LW, Hu ZB, Guo WT, Wei JS, Lin H, Sun X, Chen LX, Yang LJ (2011) Differentiation of human bone marrow mesenchymal stem cells into neuron-like cells in vitro. Spine 36(13):997–1005

    Google Scholar 

  136. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD (2009) Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 183(12):7787–7798

    CAS  Google Scholar 

  137. Zhen G, Liu H, Gu N, Zhang H, Xu Y, Zhang Z (2008) Mesenchymal stem cells transplantation protects against rat pulmonary emphysema. Front Biosci 13:3415–3422

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Guy Hilton Research Centre, Institute of Science and Technology in Medicine, Keele University, Stoke-on-Trent, ST4 7QB, UK

    Khondoker M. Akram, Sohel Samad, Monica Spiteri & Nicholas R. Forsyth

Authors
  1. Khondoker M. Akram
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sohel Samad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Monica Spiteri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nicholas R. Forsyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nicholas R. Forsyth .

Editor information

Editors and Affiliations

  1. Abt. für Plastische und Handchirurgie, Medizinische Hochschule Hannover, Hannover, Germany

    Birgit Weyand

  2. Integrated Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy

    Massimo Dominici

  3. Medizinische Hochschule Hannover, AG Biochemie und Tumorbiologie, Klinik für Frauenheilkunde und Geburtshilfe, Hannover, Germany

    Ralf Hass

  4. Medizinische Hochschule Hannover, Klinik für Immunologie und Rheumatologie, Hannover, Niedersachsen, Germany

    Roland Jacobs

  5. Department für Biotechnologie, Universität für Bodenkultur, Wien, Austria

    Cornelia Kasper

Rights and permissions

Reprints and permissions

Copyright information

© 2012 2013

About this chapter

Cite this chapter

Akram, K.M., Samad, S., Spiteri, M., Forsyth, N.R. (2012). Mesenchymal Stem Cell Therapy and Lung Diseases. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R., Kasper, C. (eds) Mesenchymal Stem Cells - Basics and Clinical Application II. Advances in Biochemical Engineering/Biotechnology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2012_140

Download citation

Publish with us

Policies and ethics

Search

Navigation