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Tissue Engineering III: Cell - Surface Interactions for Tissue Culture pp 297–315Cite as

Interaction of Cartilage and Ceramic Matrix

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Part of the book series: Advances in Biochemical Engineering Biotechnology ((ABE,volume 126))

Abstract

As subchondral bone is often affected during cartilage injuries, the aim of research is to generate osteochondral implants in vitro using tissue engineering techniques. These constructs consist of a cartilage layer grown on top of a bone phase. In clinical applications, phosphate ceramics have gained acceptance as bone substitute materials because of their great affinity to natural bone. Furthermore, the interaction between cartilage and the underlying bone equivalent is essential for the development and success of osteochondral implants. Here, the influence of a carrier containing hydroxyapatite on the quality of cartilage constructs generated in vitro is investigated. Attempts are made to explain the effects described, by considering chemical and physical properties of the biomaterial.

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Acknowledgments

We would like to thank Kerstin Michael, Ditte Siemesgelüss, Teresa Richter, Daniel Fritsch and Nadja Holstein for their excellent technical support. The project was kindly supported by DFG (PO 413/7-1) and by BWF-FHH (Tissue Engineering).

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Authors and Affiliations

  1. Institute of Advanced Ceramics, Hamburg University of Technology, Hamburg, Germany

    K. Wiegandt & R. Janssen

  2. Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, Germany

    C. Goepfert & R. Pörtner

Authors
  1. K. Wiegandt
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  2. C. Goepfert
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  3. R. Pörtner
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  4. R. Janssen
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Corresponding author

Correspondence to R. Janssen .

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Editors and Affiliations

  1. Department für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, Wien, 1190, Austria

    Cornelia Kasper

  2. , CrossBIT - Center for Biocompatibility, Hannover Medical School, Feodor-Lynen-Str. 31, Hannover, 30625, Germany

    Frank Witte

  3. , Bioprozess- und Biosystemtechnik, Technische Universität Hamburg-Harburg, Denickestrasse 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Wiegandt, K., Goepfert, C., Pörtner, R., Janssen, R. (2011). Interaction of Cartilage and Ceramic Matrix. In: Kasper, C., Witte, F., Pörtner, R. (eds) Tissue Engineering III: Cell - Surface Interactions for Tissue Culture. Advances in Biochemical Engineering Biotechnology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2011_105

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