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Clinical Application of Stem Cells in the Cardiovascular System

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Book cover Bioreactor Systems for Tissue Engineering II

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 123))

Abstract

Regenerative medicine encompasses “tissue engineering” – the in vitro fabrication of tissues and/or organs using scaffold material and viable cells – and “cell therapy” – the transplantation or manipulation of cells in diseased tissue in vivo. In the cardiovascular system, tissue engineering strategies are being pursued for the development of viable replacement blood vessels, heart valves, patch material, cardiac pacemakers and contractile myocardium. Anecdotal clinical applications of such vessels, valves and patches have been described, but information on systematic studies of the performance of such implants is not available, yet. Cell therapy for cardiovascular regeneration, however, has been performed in large series of patients, and numerous clinical studies have produced sometimes conflicting results. The purpose of this chapter is to summarize the clinical experience with cell therapy for diseases of the cardiovascular system, and to analyse possible factors that may influence its outcome.

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Authors and Affiliations

  1. Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13352, Berlin, Germany

    Christof Stamm & Kristin Klose

  2. Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

    Christof Stamm

  3. Department of Cardiothoracic Surgery, Heart Center and Center of Molecular Medicine Cologne, University of Cologne, Cologne, Germany

    Yeong-Hoon Choi

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  1. Christof Stamm
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  2. Kristin Klose
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  3. Yeong-Hoon Choi
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Correspondence to Christof Stamm .

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Editors and Affiliations

  1. Inst. Technische Chemie, Universität Hannover, Callinstr. 3, Hannover, 30167, Germany

    Cornelia Kasper

  2. Klinische und Experimentelle, Traumatologie, Ludwig Boltzmann Institut für, Donaueschingenstr. 13, Wien, 1200, Austria

    Martijn van Griensven

  3. Inst.Biotechnologie u. Verfahrenstechnik, TU Hamburg-Harburg, Denickestr. 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Stamm, C., Klose, K., Choi, YH. (2010). Clinical Application of Stem Cells in the Cardiovascular System. In: Kasper, C., van Griensven, M., Pörtner, R. (eds) Bioreactor Systems for Tissue Engineering II. Advances in Biochemical Engineering / Biotechnology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2010_77

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