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Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine

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Bioreactor Systems for Tissue Engineering II

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 123))

Abstract

Endothelial progenitor cells from peripheral blood or cord blood are attracting increasing interest as a potential cell source for cellular therapies aiming to enhance the neovascularization of tissue engineered constructs or ischemic tissues. The present review focus on a specific population contained in endothelial progenitor cell cultures designated as outgrowth endothelial cells (OEC) or endothelial colony forming cells from peripheral blood or cord blood. Special attention will be paid to what is currently known in terms of the origin and the cell biological or functional characteristics of OEC. Furthermore, we will discuss current concepts, how OEC might be integrated in complex tissue engineered constructs based on biomaterial or co-cultures, with special emphasis on their potential application in bone tissue engineering and related vascularization strategies.

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Authors and Affiliations

  1. Institute of Pathology, Universitätsmedizin der Johannes Gutenberg-Universität, Langenbeckstrasse 1, Mainz, Germany

    Sabine Fuchs, Eva Dohle, Marlen Kolbe & Charles James Kirkpatrick

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  1. Sabine Fuchs
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  2. Eva Dohle
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  3. Marlen Kolbe
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  4. Charles James Kirkpatrick
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Correspondence to Sabine Fuchs .

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Editors and Affiliations

  1. Inst. Technische Chemie, Universität Hannover, Callinstr. 3, Hannover, 30167, Germany

    Cornelia Kasper

  2. Klinische und Experimentelle, Traumatologie, Ludwig Boltzmann Institut für, Donaueschingenstr. 13, Wien, 1200, Austria

    Martijn van Griensven

  3. Inst.Biotechnologie u. Verfahrenstechnik, TU Hamburg-Harburg, Denickestr. 15, Hamburg, 21073, Germany

    Ralf Pörtner

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Fuchs, S., Dohle, E., Kolbe, M., Kirkpatrick, C.J. (2010). Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine. In: Kasper, C., van Griensven, M., Pörtner, R. (eds) Bioreactor Systems for Tissue Engineering II. Advances in Biochemical Engineering / Biotechnology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2009_65

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