Abstract
The use of on-chip cellular activity monitoring for biological/chemical sensing is promising for environmental, medical and pharmaceutical applications. The miniaturization revolution in microelectronics is harnessed to provide on-chip detection of cellular activity, opening new horizons for miniature, fast, low cost and portable screening and monitoring devices. In this chapter we survey different on-chip cellular activity detection technologies based on electrochemical, bio-impedance and optical detection. Both prokaryotic and eukaryotic cell-on-chip technologies are mentioned and reviewed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Tanaka Y, Sato K, Shimizu T, Yamato M, Okano T, Kitamori T (2007) Biosens Bioelectron 23:449–458
Bousse L (1996) Sens Actuators B 34:270
Pancrazio JJ, Whelan JP, Borkholder DA, Ma W, Stenger DA (1999) Ann Biomed Eng 27:697
Stenger DA, Gross GW, Keefer EW, Shaffer KM, Andreadis JD, Ma W, Pancrazio JJ (2001) Trends Biotechnol 19:304
Xiaorong X, Lidstrom ME, Parviz BA (2007) J Microelectromech Syst 16:429
D’Souza SF (2001) Biosens Bioelectron 16:337
Mulchandani A, Kaneva I, Chen W (1998) Anal Chem 70:5042
Reshetilov AN, Lobanov AV, Morozova NO, Gordon SH, Greene RV Leathers TD (1998) Biosens Bioelectron 13:787
Ito Y, Yamazaki S, Kano K, Ikeda T (2002) Biosens Bioelectron 17:993
Schmidt A, Standfu-Gabisch C, Bilitewski U (1996) Biosens Bioelectron 11:1139
Marincs F (2000) Appl Microbiol Biotechnol 53:536
Belkin S (2003) Curr Opin Microbiol 6:206
Gilchrist KH, Giovangrandi L, Whittington RH, Kovacs GTA (2005) Biosens Bioelectron 20:1397
Borkholder DA, Bao J, Maluf NI, Perl ER, Kovacs GTA (1997) J Neurosci Methods 77:61
Chaubey A, Malhotra BD (2002) Biosens Bioelectron 17:441
Karube I, Matsuoka H, Suzuki S (1983) Proceedings of the International Meeting on Chemical Sensors, Fukuoka, p 666
Reilly A, Kaferstein F (1997) Aquac Res 28:735
Yasukawa T, Kondo Y, Uchida I, Matsue T (1998) Chem Lett 27:767
Martinoia S, Rosso N, Grattarola M, Lorenzelli L, Margesin B, Zen M (2001) Biosens Bioelectron 16:1043
Shibuki K (1990) Neurosci Res 9:69
Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, Maeda H (1993) Biochemistry 32:827
Popovtzer R, Neufeld T, Biran N, Ron EZ, Rishpon J, Shacham-Diamand Y (2005) Nano Lett 5:1023
Hoeber R (1910) Arch Ges Physiol 133:237
Schwan HP, Bothwell TP, Wiercinski FJ (1954) Fed Proc Am Soc Exp Biol 13:15
Schwan HP, Bothwell TP (1956) Nature 178:265
Guan JG, Miao YQ, Zhang QJ (2004) J Biosci Bioeng 97:219
Gomez R, Bashir R, Bhunia AK (2002) Sens Actuators B 86:198
Wegener J, Keese CR, Giaever I (2000) Exp Cell Res 259:158
Xiao C, Luong JHT (2003) Biotechnol Prog 19:1000
Chang BW, Chen CH, Ding SJ, Chen DCH, Chang HC (2005) Sens Actuators B 105:163
Chouteau C, Dzyadevych S, Durrieu C, Chovelon JM (2005) Biosens Bioelectron 21:273
Abdur Rahman AR, Lo C, Bhansali S (2006) Sens Actuators B 118:115
Schwan HP (1963) Physical techniques in biological research, vol VI. Electro-physiological methods. Academic, New York
Foster KR, Schwan HP (1989) Crit Rev Biomed Eng 17:25
Barber DC, Brown BH (1984) J Phys E Sci Instrum 17:723
Metherall P, Barber DC, Smallwood RH, Brown BH (1996) Nature 380:509
Bernstein DP (1986) Crit Care Med 14:904
Ron A, Singh RR, Fishelson N, Shur I, Socher R, Benayahu D, Shacham-Diamand Y (2008) Biophys Chem 135:59
Wang J (2006) Biosens Bioelectron 21:1887
Popovtzer R, Neufeld Y, Popovtzer A, Rivkin I, Margalit R, Engel D, Abraham MA, Nudelman R, Rishpon J, Shacham-Diamand Y (2008) Nanomed Nanotechnol Biol Med 4:121
Rasooly A, Jacobson J (2006) Biosens Bioelectron 21:1851
Sefi Vernick (2008) Private communication
Belkin S (2003) Curr Opin Microbiol 6:206
Vijayaraghavan R, Islam SK, Zhang M, Ripp S, Caylor S, Bull ND, Moser S, Terry SC, Blalock BJ, Sayler GS (2007) Sens Actuators B 123:922
Daniel R, Almog R, Ron A, Belkin S, Shacham-Diamand Y (2008) Biosens Bioelectron 24:888
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Almog, R., Daniel, R., Vernick, S., Ron, A., Ben-Yoav, H., Shacham-Diamand, Y. (2009). On-Chip Detection of Cellular Activity. In: Belkin, S., Gu, M. (eds) Whole Cell Sensing Systems I. Advances in Biochemical Engineering / Biotechnology, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2009_1
Download citation
DOI: https://doi.org/10.1007/10_2009_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-12361-0
Online ISBN: 978-3-642-12362-7
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)