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Disposables in Downstream Processing

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Disposable Bioreactors

Part of the book series: Advances in Biochemical Engineering / Biotechnology ((ABE,volume 115))

Abstract

Disposable equipment has been used for many years in the downstream processing industry, but mainly for filtration and buffer/media storage. Over the last decade, there has been increasing interest in the use of disposable concepts for chromatography, replacing steel and glass fixed systems with disposable plastic modules that can be discarded once exhausted, fouled or contaminated. These modules save on cleaning and validation costs, and their reduce footprints reduce buffer consumption, water for injection, labor and facility space, contributing to an overall reduction in expenditure that lowers the cost of goods. This chapter examines the practical and economic benefits of disposable modules in downstream processing.

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Abbreviations

BSA:

Bovine serum albumin

cGMP:

Current good manufacturing practice

CIP:

Cleaning in place

DNA:

Deoxyribonucleic acid

LRV:

Log reduction value

MuLV:

Murine leukemia virus

MVM:

Minute virus of mice

PRV:

Pseudorabies Virus

SIP:

Steaming in place

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Author information

Authors and Affiliations

  1. Sartorius-Stedim Biotech GmbH, August-Spindler-Straße 11, 37079, Goettingen, Germany

    Uwe Gottschalk

Authors
  1. Uwe Gottschalk
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Corresponding author

Correspondence to Uwe Gottschalk .

Editor information

Editors and Affiliations

  1. Hochschule Wädenswil, Wädenswil, Switzerland

    Regine Eibl

  2. Hochschule Wädenswil, Wädenswil, Switzerland

    Dieter Eibl

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© 2009 Springer-Verlag Berlin Heidelberg

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Gottschalk, U. (2009). Disposables in Downstream Processing. In: Eibl, R., Eibl, D. (eds) Disposable Bioreactors. Advances in Biochemical Engineering / Biotechnology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2008_22

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