Abstract
This review addresses the recent developments in miniaturized microsystems or lab-on-a-chip devices for biosensing of different biomolecules: DNA, proteins, small molecules, and cells, especially at the single-molecule and single-cell level. In order to sense these biomolecules with sensitivity we have fabricated chip devices with respect to the biomolecule to be analyzed. The details of the fabrication are also dealt with in this review. We mainly developed microarray and microfluidic chip devices for DNA, protein, and cell analyses. In addition, we have introduced the porous anodic alumina layer chip with nanometer scale and gold nanoparticles for label-free sensing of DNA and protein interactions. We also describe the use of microarray and microfluidic chip devices for cell-based assays and single-cell analysis in drug discovery research.
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References
Dittrich S, Rachikawa K, Manz A (2006) Anal Chem 78:3887
Yi C, Li C-W, Ji S, Yang M (2006) Anal Chim Acta 560:1
Oosterbroek E, Van den Berg A (2003) Lab-on-a-chip: miniaturized systems for biochemical analysis and synthesis. Elsevier, Amsterdam
Figeys D, Pinto D (2000) Anal Chem 72:330
Heller MJ (2002) Annu Rev Biomed Eng 4:129
Eisen MB, Brown PO (1999) Methods Enzymol 303:179
Panicker RC, Huang X, Yao SQ (2004) Comb Chem High Throughput Screen 7:547
Figeys D (2002) Proteomics 2:373
Smith JC, Lambert J-P, Elisma F, Figeys D (2007) Anal Chem 79:4325
Craighead H (2006) Nature 442:387
El-Ali J, Sorger PK, Jensen KF (2006) Nature 442:403
Cottingham K (2004) Anal Chem 76:235
Di Carlo D, Lee L (2006) Anal Chem 78:7918
Price AK, Culbertson CT (2007) Anal Chem 79:2614
Anderson DG, Levenberg S, Langer R (2004) Nat Biotechnol 22:863
Ziauddin J, Sabatini DM (2001) Nature 411:107
Mullis KB, Faloona FA (1987) Methods Enzymol 155:335
Irino T, Kitoh T, Koami K, Kashima T, Mukai K, Takeuchi E, Hongo T, Nakahata T, Schuster SM, Osaka M (2004) J Mol Diagn 6:217
Hirt C, Schuler F, Dolken L, Schmidt CA, Dolken G (2004) Blood 104:904
Nurmi J, Wikman T, Karp M, Lovgren T (2002) Anal Chem 74:3525
Yang J, Liu Y, Rauch CB, Stevens RL, Liu RH, Lenigk R, Grodzinski P (2002) Lab Chip 2:179
Lee TMH, Carles MC, Hsing IM (2003) Lab Chip 3:100
Schneegass I, Brautigam R, Kohler M (2001) Lab Chip 1:42
Fukuba T, Yamamoto T, Naganuma T, Fujii T (2004) Chem Eng J 101:151
Lee DS, Park SH, Yang H, Chung KH, Yoon TH, Kim SJ, Kim K, Kim YT (2004) Lab Chip 4:401
Lagally ET, Emrich CA, Mathies R (2001) Lab Chip 1:102
Lagally ET, Medintz I, Mathies RA (2001) Anal Chem 73:565
Nagai H, Murakami Y, Yokoyama K, Tamiya E (2001) Biosens Bioelectron 16:1015
Nagai H, Murakami Y, Morita Y, Yokoyama K, Tamiya E (2001) Anal Chem 73:1043
Matsubara Y, Kobayashi M, Morita Y, Tamiya E (2002) Arch Histol Cytol 65:481
Leamon JH, Lee WL, Tartaro KR, Lanza JR, Sarkis GJ, deWinter AD, Berka J, Lohman KL (2003) Electrophoresis 24:3769
Matsubara Y, Kerman K, Kobayashi M, Yamamura S, Morita Y, Takamura Y, Tamiya E (2004) Anal Chem 76:6434
Matsubara Y, Kerman K, Kobayashi M, Yamamura S, Morita Y, Tamiya E (2005) Biosens Bioelectron 20:1482
Felbel J, Bieber I, Pipper J, Kohler JM (2004) Chem Eng J 101:333
Shoffner MA, Cheng J, Hvichia GE, Kricka LJ, Wilding P (1996) Nucleic Acids Res 24:375
Erill I, Campoy S, Erill N, Barbe J, Aguilo J (2003) Sens Actuators B 96:685
Zimmermann B, Holzgreve W, Wenzel F, Hahn S (2002) Clin Chem 48:362
Kariyazono H, Ohno T, Ihara K, Igarashi H, Joh-o K, Ishikawa S, Hara T (2001) Mol Cell Probes 15:71
Chiu RW, Lau TK, Leung TN, Chow KC, Chui DH, Lo YM (2002) Lancet 360:998
Breadmore MC, Wolfe KA, Arcibal IG, Leung WK, Dickson D, Giordano BC, Power ME, Ferrance JP, Feldman SH, Norris PM, Landers JP (2003) Anal Chem 75:1880
Holden MA, Kumar S, Castellana ET, Beskok A, Cremer PS (2003) Sens Actuators B 92:199
He B, Burke BJ, Zhang X, Zhang R, Regnier FE (2001) Anal Chem 73:1942
Lin Y, Gerfen GJ, Rousseau DL, Yeh S-R (2003) Anal Chem 75:5381
Lim T-K, Ohta H, Matsunaga T (2003) Anal Chem 75:3316
Nakamura H, Karube I (2003) Anal Bioanal Chem 377:446
Vilkner T, Janasek D, Manz A (2004) Anal Chem 76:3373
Yu C, Mutlu S, Selvaganapathy P, Mastrangelo CH, Svec F, Frechet JMJ (2003) Anal Chem 75:1958
Melin J, Roxhed N, Gimenez G, Griss P, van der Wijngaart W, Stemme G (2004) Sens Actuators B 100:463
Takamura Y, Onoda H, Inokuchi H, Adachi S, Oki A, Horiike Y (2003) Electrophoresis 24:185
Lim K, Kim S, Hahn JH (2003) Sens Actuators B 92:208
Huh D, Tkaczk AH, Bahng JH, Chang Y, Wei H-H, Grotberg JB, Kim C-J, Kurabayashi K, Takayama S (2003) J Am Chem Soc 125:14678
Valasek MA, Repa JJ (2005) Adv Physiol Educ 29:151
Kopp MU, de Mello AJ, Manz A (1998) Science 280:1046
Obeid PJ, Christopoulos TK, Crabtree HJ, Backhouse CJ (2003) Anal Chem 75:288
Obeid PT, Christopoulos TK (2003) Anal Chim Acta 494:1
Zhang Q, Wang W, Zhang H, Wang Y (2002) Sens Actuators B 82:75
Sun K, Yamaguchi A, Ishida Y, Matsuo S, Misawa H (2002) Sens Actuators B 84:283
Shindo Y, Kuribara H, Matsuoka T, Futo S, Sawada C, Shono J, Akiyama H, Doda Y, Toyoda M, Hino A (2002) J AOAC Int 85:1119
Duffy DC, McDonald JC, Schueller OJA, Whitesides GM (1998) Anal Chem 70:4974
Kuribara H, Shindo Y, Matsuoka T, Takubo K, Futo S, Aoki N, Hirao T, Akiyama H, Doda Y, Toyoda M, Hino A (2002) J AOAC Int 85:1077
Pattnaik P (2005) Appl Biochem Biotechnol 26:79
Lahiri J, Isaacs L, Tien J, Whitesides GM (1999) Anal Chem 71:777
Nakamura R, Muguruma H, Ikebukuro K, Sasaki S, Nagata R, Karube I, Pedersen H (1997) Anal Chem 69:4649
Kai E, Sawata S, Ikebukuro K, Iida T, Honda T, Karube I (1999) Anal Chem 71:796
Jordan CE, Frutos AG, Thiel AG, Corn RM (1997) Anal Chem 69:4939
Goodrich TT, Lee HJ, Corn RM (2004) J Am Chem Soc 126:4086
Wark AW, Lee HJ, Corn RM (2005) Anal Chem 77:3904
Woodruff SD, Yeung ES (1982) Anal Chem 54:1174
Wang Z, Bornhop DJ (2005) Anal Chem 77:7872
Markov DA, Swinney K, Bornhop DJ (2004) J Am Chem Soc 126:16659
Dancil K-PS, Greiner DP, Sailor MJ (1999) J Am Chem Soc 121:7925
Lin VS-Y, Motesharei K, Dancil K-PS, Sailor MJ, Ghadiri MR (1997) Science 278:840
Doan VV, Sailor MJ (1992) Science 256:1791
Boussaad S, Pean J, Tao NJ (2000) Anal Chem 72:222
Sota H, Hasegawa Y, Iwakura M (1998) Anal Chem 70:2019
Lu J, Strohsahl CM, Miller BL, Rothberg LJ (2004) Anal Chem 76:4416
Pan S, Rothberg LJ (2003) Nano Lett 3:811
Eustis S, el-Sayed MA (2006) Chem Soc Rev 35:209
McFarland AD, Van Duyne RP (2003) Nano Lett 3:1057
Mie G (1908) Ann Phys 25:377
Barnes WL, Dereux A, Ebbesen TW (2003) Nature 424:824
Kreibig U, Vollmer M (1995) Optical properties of metal clusters. Springer, Heidelberg
Prasad NP (2004) Nanophotonics. Wiley, Hoboken, p 129
Stuart DA, Haes AJ, Yonzon CR, Hicks EM, Van Duyne RP (2005) IEE Proc Nanobiotechnol 152:13
Freeman RG, Grabar KC, Allison KJ, Bright RM, Davis JA, Guthrie AP, Hommer MB, Jackson MA, Smith PC, Walter DG, Natan MJ (1995) Science 267:1629
Nath N, Chilkoti A (2004) Anal Chem 76:5370
Nath N, Chilkoti A (2002) Anal Chem 74:504
Mock JJ, Smith DR, Schultz S (2003) Nano Lett 3:485
Raschke G, Kowarik S, Franzl T, Sönnichsen C, Klar TA, Feldmann J, Nichtl A, Kürzinger K (2003) Nano Lett 3:935
Endo T, Kerman K, Nagatani N, Takamura Y, Tamiya E (2005) Anal Chem 77:6976
Endo T, Yamamura S, Nagatani N, Morita Y, Takamura Y, Tamiya E (2005) Sci Technol Adv Mater 6:491
Endo T, Kerman K, Nagatani N, Hiep HM, Kim D-K, Yonezawa Y, Nakano K, Tamiya E (2006) Anal Chem 78:6465
Mock JJ, Smith DR, Schultz S (2003) Nano Lett 3:485
Masuda H, Satoh M (1996) Jpn J Appl Phys 35:126
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Science 261:921
Rudert F (2000) Curr Opin Mol Ther 2:633
Srinivas PR, Srivastava S, Hanash S, Wright GL Jr (2201) Clin Chem 47:1901
Figeys D, Pinto D (2001) Electrophoresis 22:208
Reid G, Gan BS, She YM, Ens W, Weinberger S, Howard JC (2002) Appl Environ Microbiol 68:977
Tabuchi M, Baba Y (2002) Electrophoresis 23:1138
Venter JC et al Science 291:1304
Pavlov MY, Freistroffer DV, Ehrenberg M (1997) Biochimie 79:415
Zhi ZL, Murakami Y, Morita Y, Hasan Q, Tamiya E (2003) Anal Biochem 318:236
Zhi ZL, Morita Y, Hasan Q, Tamiya E (2003) Anal Chem 75:4125
Kukar T, Eckenrode S, Gu Y, Lian W, Megginson M, She JX, Wu D (2002) Anal Biochem 306:50
Kojima K, Hiratsuka A, Suzuki H, Yano K, Ikebukuro K, Karube I (2003) Anal Chem 75:1116
Tabuchi M, Hino M, Shinohara Y, Baba Y (2002) Proteomics 2:430
Rungpragayphan S, Kawarasaki Y, Imaeda T, Kohda K, Nakano H, Yamane T (2002) J Mol Biol 318:395
Nakano H, Okumura R, Goto C, Yamane T (2002) Biotechnol Bioprocess Eng 7:311
McDonald JC, Whitesides GM (2002) Acc Chem Res 35:491
Ng JM, Gitlin I, Stroock AD, Whitesides GM (2002) Electrophoresis 23:3461
Jo BH, Van Lerberghe LM, Motsegood KM, Beebe DJ (2000) J Microelectromech Syst 9:76
Spirin AS, Baranov VI, Ryabova LA, Ovodov SY, Alakhov YB (1988) Science 242:1162
Brenner S, Williams SR, Vermaas EH, Storck T, Moon K, McCollum C, Mao JI, Luo S, Kirchner JJ, Eletr S, DuBridge RB, Burcham T, Albrecht G (2000) Proc Natl Acad Sci USA 97:1665
Drewes G, Bouwmeester T (2003) Curr Opin Cell Biol 15:199
Petach H, Gold L (2002) Curr Opin Biotechnol 13:309
Talapatra A, Rouse R, Hardiman G (2002) Pharmacogenomics 3:527
Workman J Jr, Koch M, Veltkamp D (2005) Anal Chem 77:3789
Gardeniers H, Van Den Berg A (2004) Int J Environ Anal Chem 84:809
Murakami Y, Endo T, Yamamura S, Nagatani N, Takamura Y, Tamiya E (2004) Anal Biochem 334:111
Shaikh KA, Ryu KS, Goluch ED, Nam JM, Liu J, Thaxton CS, Chiesl TN, Barron AE, Lu Y, Mirkin CA, Liu C (2005) Proc Natl Acad Sci USA 102:9745
Haes AJ, Chang L, Klein WL, Van Duyne RP (2005) J Am Chem Soc 127:2264
Himmelhaus M, Takei H (2000) Sens Actuators B 63:24
Bliss TVP, Collinbridge GL (1993) Nature 361:31
Ehlers MD, Mammen AL, Lau L, Hunganir L (1996) Curr Opin Cell Biol 8:484
Petrlia R, Yokotani N, Wenthold R (1994) J Neurosci 14:667
Tamiya E, Nagatani N, Iwabuchi S, Murakami Y, Sakaguchi T, Yokoyama K (1997) Anal Chem 69:3697
Iwabuchi S, Muramatsu H, Yamamoto N, Murakami Y, Yokoyama Y, Tamiya E (1996) Opt Rev 3:470
Degenaar P, Murakami Y, Yokoyama K, Tamiya E (2000) Proc NFO 6:271
Chiu DT, Jeon NL, Huang S, Kane RS, Wargo CL, Cho IS, Ingber DE, Whitesides GM (2000) Proc Natl Acad Sci USA 97:2408
Matsuda T, Sugawara T, Inoue K (1992) ASAIO J 243
Mrksich M, Dike EL, Tien J, Ingber DE, Whitesides GM (1997) Exp Cell Res 235:305
Matinoia S, Bove M, Tedesco M, Margesin B, Grattarola M (1999) J Neurosci Methods 87:35
Degenaar P, Griscom L, Le Pfioufle B, Murakami Y, Yokoyama K, Fujita H, Tamiya E (2001) Proc Biochips 2001
Givangrandi L (1999) PhD thesis, École polytechnique Fédérale de Lausanne. Lausanne, Switzerland
Shirakawa T, Honma S, Katsuno Y, Oguchi H, Honma K (2000) Eur J Neurosci 12:2833
Degenaar P, Le Pioufle B, Griscom L, Tixier A, Akagi Y, Morita Y, Murakami Y, Yokoyama K, Fujita H, Tamiya E (2001) J Biochem 130:367
Morin F, Nishimura N, Griscom L, Le Pioufle B, Fujita H, Takamura Y, Tamiya E (2006) Biosens Bioelectron 21:1093
Wolcke J, Ullmann D (2001) Drug Discov Today 6:637
Hertzberg RP, Pope AJ (2000) Curr Opin Biotechnol 4:445
Sundberg SA (2000) Curr Opin Biotechnol 11:47
Houseman BT, Huh JH, Kron SJ, Mrksich M (2002) Nat Biotechnol 20:270
Lavery P, Brown MJB, Pope AJ (2001) J Biomol Screen 6:3
Mere L, Bennett T, Coassin P, England P, Hamman B, Rink T, Zimmerman S, Negulescu P (1999) Drug Discov Today 4:363
Kariv I, Cao H, Marvil PD, Bobkova EV, Bukhitiyarov YE, Yan YP, Patel U, Coudurier L, Chung TDY, Oldenburg KR (2001) J Biomol Screen 6:233
Turconi S, Shea K, Ashman S, Fantom K, Earnshaw DL, Bingham RP, Haupts UM, Brown MJB, Pope AJ (2001) J Biomol Screen 6:275
Sittampalam GS, Kahn SD, Janzen WP (1997) Curr Opin Chem Biol 1:384
Bhandariraju K, Chen CS (2002) Drug Discov Today 7:612
Giese K, Kaufmann J, Pronk GJ, Klippel A (2002) Drug Discov Today 7:179
Gonzalez-Nicolini V, Fux C, Fussenegger M (2004) Invest New Drugs 22:253
Tucker CL (2002) Drug Discov Today 7:S125
Zheng W, Brandish PE, Kolodin DG, Scolnick EM, Strulovici B (2004) J Biomol Screen 9:132
Lindholm P, Gullbo J, Claeson P, Goransson U, Johansson S, Backlund A, Larsson R, Bohlin L (2002) J Biomol Screen 7:333
Akagi Y, Sathuluri RR, Morita Y, Tamiya E (2004) Sci Technol Adv Mater 5:343
Oldenburg KR, Zhang JH, Chen T, Maffia A III, Blom KF, Combs AP, Chung TDY (1998) J Biomol Screen 1:55
Anonymous (2003) Cell counting kit-F. Technical manual of DOJINDO, p 260
Greene LA, Tischeler AS (1976) Proc Natl Acad Sci USA 73:2424
Lad SP, Neet KE, Mufson EJ (2003) Curr Drug Targets CNS Neurol Disord 2:315
Salehi A, Delcroix JD, Swabb DF (2004) J Neural Transm 111:323
Stevens T, Livingston G, Kitchen G, Manela M, Walker Z, Katona C (2002) Br J Psychiatry 180:270
Poduslo JF, Curran GL (1996) Brain Res Mol Brain Res 36:280
Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Backman C, Bergman H, Hoffer B, Bloom F, Granholm AC (1993) Science 259:373
Falciani C, Lozzi L, Pini A, Bracci L (2005) Chem Biol 12:417
Blondelle SE, Perez-Paya E, Houghten RA (1996) Antimicrob Agents Chemother 40:1067
Dooley CT, Ny P, Bidlack JM, Houghten RA (1998) J Biol Chem 273:18848
Hernandez J, Schoeder K, Blondelle SE, Pons FG, Lone YC, Simora A, Linglade-Demoyen P, Wilson DB, Zanette M (2004) Eur J Immunol 34:2331
Oyama T, Sykes KF, Samli KN, Minna JD, Johnston SA, Brown KC (2003) Cancer Lett 202:219
Takahashi S, Mok H, Parrott B, Marini FC III, Andreeff M, Brenner MK, Barry MA (2003) Cancer Res 63:5213
Bae YS, Park EY, Kim Y, He R, Ye RD, Kwak JY, Suh PG, Ryu SH (2003) Biochem Pharmacol 66:1841
Kuruvilla HW, Shamji AF, Sternson SM, Hergenrother PJ, Schreiber SL (2002) Nature 416:653
Kai J, Nakamura K, Masuda T, Ueda I, Fujiwara H (1996) J Med Chem 29:2621
Pardridge WM (2005) NeuroRx 2:3
Pardridge WM (2003) Mol Interv 3:90
Gardiner RM (1990) J Inherit Metab Dis 13:627
Oldendorf WH (1974) Proc Soc Exp Bio Med 147:813
Banks WA, Kastin AJ (1985) Brain Res Bull 15:287
Macbeath G, Koehler AN, Schreiber SL (1999) J Am Chem Soc 121:7967
Liu R, Marik J, Lam KS (2002) J Am Chem Soc 124:767
Chen GYJ, Uttamchandani M, Ziu Q, Wang G, Yao SQ (2003) ChemBioChem 4:336
Kodadek T, Bachhawat-Sikder K (2006) Mol Biosyst 2:25
Ronn LCB, Olsen M, Ostergaard S, Kiselyov V, Berezin V, Mortensen MT, Lerche MH, Jensen PH, Soroka V, Saffells JL, Doherty P, Poulsen FM, Bock E, Holm A (1999) Nat Biotechnol 17:1000
Ronn LCB, Olsen M, Soroka V, Ostergaard S, Dissing S, Poulsen FM, Holm A, Berezin V, Bock E (2002) Eur J Neurosci 16:1720
Luthi A, Laurent JP, Figurov A, Luller D, Schachner M (1994) Nature 372:777
Lam KS, Lebl M, Krchnak V (1997) Chem Rev 97:411
Shokrgozar MA, Shokri F (2001) Immunology 101:75
Thorsen T, Maerkl SJ, Quake SR (2002) Science 298:580
Yamamura S, Sathuluri RR, Omori M, Tokimitsu Y, Kondo S, Kishi H, Muraguchi A, Takamura Y, Tamiya E (2004) Proc Micro Total Anal Systems, vol 1. Royal Society of Chemistry, Cambridge, p 78
Sathuluri RR, Yamamura S, Takamura Y, Tamiya E (2004) Proc Micro Total Anal Systems, vol 1. Royal Society of Chemistry, Cambridge, p 61
Yamamura S, Kishi H, Tokimitsu Y, Kondo S, Honda R, Sathuluri RR, Omori M, Tamiya E, Muraguchi A (2005) Anal Chem 77:8050
Haugland RP (2002) In: Handbook of fluorescent probes and research products, 9th edn. Molecular Probes, Eugene
Nishida M, Sugimoto K, Hara Y, Mori E, Mori T, Kurosaki T, Mori Y (2003) EMBO J 22:4677
Ueki Y, Goldfarb IS, Harindranath N, Gore M, Koprowski H, Notkins AL, Casali P (1990) J Exp Med 171:19
Jingwu Z, Henderikx P, Ying C, Medaer R, Raus JCM (1989) J Immunol Methods 123:153
Dessain SK, Adekar SP, Stevens JB, Carpenter KA, Skorski ML, Barnoski BL, Goldsby RA, Weinberg RA (2004) J Immunol Methods 291:109
Martin JC, Swartzendruber DE (1980) Science 207:199
Wheeler AR, Thronsdset WR, Whelan RJ, Leach AM, Zare RN, Liaor YH, Farrell K, Manger ID, Daridon A (2003) Anal Chem 75:3581
Wu HK, Wheeler A, Zare RN (2004) Proc Natl Acad Sci USA 101:12809
Peng XY, Li PCH (2004) Anal Chem 76:5273
Yang MS, Li CW, Yang J (2002) Anal Chem 74:3991
Sathuluri RR, Kitamura M, Yamamura S, Tamiya E (2006) Proc Micro Total Anal Systems, vol 1. Royal Society of Chemistry, Cambridge, p 957
Sathuluri RR, Kitamura M, Yamamura S, Tamiya E (2006) Proc IEEE Sensors, p 642
Yamamura S, Sathuluri RR, Tamiya E (2007) Pico/nano-liter chamber array chips for single-cell, DNA and protein analyses. In: Kumar C (ed) Nanomaterials for Biosensors, vol 8. Wiley-VCH, Weinheim, p 368
Nakayama T, Kurosawa Y, Furui S, Kerman K, Kobayashi M, Sathuluri RR, Yonezawa Y, Nakano K, Hino A, Yamamura S, Takamura Y, Tamiya E (2006) Anal Bioanal Chem 386:1327
Kim DK, Kerman K, Saito M, Sathuluri RR, Endo T, Yamamura S, Kwon YS, Tamiya E (2007) Anal Chem 79:1855
Kinapara T, Mizuno R, Murakami Y, Kobayashi M, Yamamura S, Hasan Q, Morita Y, Nakano H, Yamane T, Tamiya E (2004) J Biochem (Tokyo) 136:149
Sathuluri RR, Akagi Y, Morita Y, Tamiya E (2002) Proc Micro Total Anal Systems, vol 2. Kluwer Academic Publishers, Netherlands, p 862
Akagi Y, Sathuluri RR, Morita Y, Takamura Y, Tamiya E (2004) Proc Micro Total Anal Systems, vol 2. Royal Socitey of Chemistry, Cambridge, p 309
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Sathuluri, R.R., Yamamura, S., Tamiya, E. (2007). Microsystems Technology and Biosensing. In: Renneberg, R., Lisdat, F. (eds) Biosensing for the 21st Century. Advances in Biochemical Engineering/Biotechnology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2007_078
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