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Amplified Transduction of Biomolecular Interactions Based on the Use of Nanomaterials

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Biosensing for the 21st Century

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 109))

Abstract

The achievement of very high sensitivity is a major goal in biological assays such as the monitoring of DNA hybridization or protein interactions. This chapter reviews progress in the development of nanomaterials for amplified biosensing and discusses different nanomaterial-based bioamplification strategies. The emergence of nanotechnology is opening new horizons for highly sensitive bioassays and for novel biosensor protocols that employ electronic, optical, or microgravimetric signal transduction. Antibodies or nucleic acids functionalized with metal or semiconductor nanoparticles have been employed as amplifying tags for the biodetection of proteins and DNA. The coupling of different nanomaterial-based amplification platforms and amplification processes dramatically enhances the intensity of the analytical readout and leads to ultrasensitive bioassays. The remarkable sensitivity of the new nanomaterial-based sensing protocols opens up the possibility of detecting disease markers, biothreat agents, or infectious agents that cannot be measured by conventional methods.

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Authors and Affiliations

  1. Biodesign Institute, Departments of Chemical Engineering and Chemistry and Biochemistry, Arizona State University, 85287-5801, Tempe, Arizona, USA

    Joseph Wang

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  1. Joseph Wang
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Correspondence to Joseph Wang .

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Reinhard Renneberg Fred Lisdat

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© 2007 Springer-Verlag Berlin Heidelberg

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Wang, J. (2007). Amplified Transduction of Biomolecular Interactions Based on the Use of Nanomaterials. In: Renneberg, R., Lisdat, F. (eds) Biosensing for the 21st Century. Advances in Biochemical Engineering/Biotechnology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2007_074

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