Skip to main content

Perspectives for Facial Allograft Transplantation in Humans

  • Chapter
Tissue Surgery

Part of the book series: New Techniques in Surgery Series ((NEWTECHN,volume 1))

  • 1046 Accesses

Abstract

The face is a functional as well as an esthetic part of the body. It is the window through which we interact with others: two thirds of our communication is through nonverbal facial expressions. Reconstructing partial or full facial deformities caused by burns, trauma, or tumors still challenges most reconstructive surgeons. The ideal reconstructive procedure should address both the functional and esthetic units of the face.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ergun SS, Cek DI, Demirkesen C. Is facial resurfacing with monobloc full-thickness skin graft a remedy in xeroderma pigmentosum? Plast Reconstr Surg. 2002;110:1290–1293.

    Article  PubMed  Google Scholar 

  2. Ashall G, Quaba AA, Hackett ME. Facial resurfacing in xeroderma pigmentosum: are we spoiling the ship for a ha’p’orth of tar? Br J Plast Surg. 1987;40:610–613.

    Article  PubMed  CAS  Google Scholar 

  3. Erol OO. The transformation of a free skin graft into a vascularized pedicle flap. Plast Reconstr Surg. 1976;58;470–477.

    Article  PubMed  CAS  Google Scholar 

  4. Pribaz JJ, Fine N, Orgill DP. Flap prefabrication in the head and neck: a 10-year experience. Plast Reconstr Surg. 1999;103:808–820.

    Article  PubMed  CAS  Google Scholar 

  5. Khouri RK, Upton J, Shaw WW. Prefabrication of composite free flaps through staged microvascular transfer: an experimental and clinical study. Plast Reconstr Surg. 1991;87:108–115.

    Article  PubMed  CAS  Google Scholar 

  6. Teot L, Cherenfant E, Otman S, et al. Prefabricated vascularised supraclavicular flaps for face resurfacing after postburns scarring. Lancet. 2000;355:1695–1696.

    Article  PubMed  CAS  Google Scholar 

  7. Boyd JB. Tissue expansion in reconstruction. South Med J. 1987;80:430–432.

    Article  PubMed  CAS  Google Scholar 

  8. Wilmshurst AD, Sharpe DT. Immediate placement of tissue expanders in the management of large excisional defects on the face. Br J Plast Surg. 1990;43:150–153.

    Article  PubMed  CAS  Google Scholar 

  9. Kawashima T, Yamada A, Ueda K, et al. Tissue expansion in facial reconstruction. Plast Reconstr Surg. 1994;94:944–950.

    Article  PubMed  CAS  Google Scholar 

  10. Spence RJ. Experience with novel uses of tissue expanders in burn reconstruction of the face and neck. Ann Plast Surg. 1992;28:453–464.

    Article  PubMed  CAS  Google Scholar 

  11. Harii K, Ohmori K, Ohmori S. Utilization of free composite tissue transfer by microvascular anastomosis for the repair of burn deformities. Burn. 1975;1:237–244.

    Article  Google Scholar 

  12. Burget GC, Menick FJ. The subunit principle in nasal reconstruction. Plast Reconstr Surg. 1985;76:239–247.

    Article  PubMed  CAS  Google Scholar 

  13. Feldman JJ. Facial resurfacing: the single sheet concept. In: Brent B, editor. The Artistry of Plastic Surgery. St. Louis: Mosby, 1987.

    Google Scholar 

  14. Angrigiani C, Grilli D. Total face reconstruction with one free flap. Plast Reconstr Surg. 1997;99:1566–1575.

    Article  PubMed  CAS  Google Scholar 

  15. Miller GD, Auster EJ, Shell JA. Successful replantation of an avulsed scalp by microsurgical anastomoses. Plast Reconstr Surg. 1976;58:133–136.

    Article  PubMed  CAS  Google Scholar 

  16. Cheng K, Zhou S, Jiang K, et al. Replantation of the avulsed scalp: report of 20 cases. Plast Reconstr Surg. 1996;97:1099–1106.

    Article  PubMed  CAS  Google Scholar 

  17. Hammond DC, Bouwense C, Hankins WT, et al. Microsurgical replantation of the amputated nose. Plast Reconstr Surg. 2000;105:2133–2136.

    Article  PubMed  CAS  Google Scholar 

  18. Concannon MJ, Puckett CL. Microsurgical replantation of an ear in a child without venous repair. Plast Reconstr Surg. 1998;102:2088–2093.

    Article  PubMed  CAS  Google Scholar 

  19. Jeng SF, Wei FC, Noordhoff MS. Successful replantation of a bitten-off vermilion of the lower lip by microvascular anastomosis: case report. J Trauma. 1992;33:914–916.

    Article  PubMed  CAS  Google Scholar 

  20. Thomas A, Obed V, Murarka A, et al. Total face and scalp replantation. Plast Reconstr Surg. 1998;102:2085–2087.

    Article  PubMed  CAS  Google Scholar 

  21. Wilhelmi BJ, Kang RH, Movassaghi K, et al. First successful replantation of face and scalp with single-artery repair: model for face and scalp transplantation. Ann Plast Surg. 2003;50:535–540.

    Article  PubMed  Google Scholar 

  22. Kahan BD. Cosmas and Damian in the 20th century? N Engl J Med. 1981;305:280–281.

    Article  PubMed  CAS  Google Scholar 

  23. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet. 1999;353:1315–1320.

    Article  PubMed  CAS  Google Scholar 

  24. Petit F, Minns AB, Dubernard JM, et al. Composite tissue allotransplantation and reconstructive surgery: first clinical applications. Ann Surg. 2003;237:19–25.

    Article  PubMed  Google Scholar 

  25. Cendales L, Breidenbach W, Granger DK, et al. Evaluation of function following human hand transplantation [Abstract]. Transplantation. 2000;69:S295.

    Google Scholar 

  26. Jones JW, Gruber SA, Barker JH, et al. Successful hand transplantation. One-year follow-up. N Engl J Med. 2000;343:468–473.

    Article  PubMed  CAS  Google Scholar 

  27. Francois CG, Breidenbach WC, Maldonado C, et al. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery. 2000;20:360–371.

    Article  PubMed  CAS  Google Scholar 

  28. Hettiaratchy S, Randolph MA, Petit F, et al. Composite tissue allotransplantation—a new era in plastic surgery? Br J Plast Surg. 2004;57:381–391.

    Article  PubMed  Google Scholar 

  29. Levi DM, Tzakis AG, Kato T, et al. Transplantation of the abdominal wall. Lancet. 2003;36:2173–2176.

    Article  Google Scholar 

  30. Hofmann GO, Kirschner MH, Wagner FD, et al. Allogeneic vascularized transplantation of human femoral diaphyses and total knee joints—first clinical experiences. Transplant Proc. 1998;30:2754–2761.

    Article  PubMed  CAS  Google Scholar 

  31. Mackinnon SE, Doolabh VB, Novak CB, et al. Clinical outcome following nerve allograft transplantation. Plast Reconstr Surg. 2001; 107:1419–1429.

    Article  PubMed  CAS  Google Scholar 

  32. Guimberteau JC, Baudet J, Panconi B, et al. Human allotransplant of a digital flexion system vascularized on the ulnar pedicle: a preliminary report and 1-year follow up of two cases. Plast Reconstr Surg. 1992; 89:1135–1147.

    Article  PubMed  CAS  Google Scholar 

  33. Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med. 2001;344:1676–1679.

    Article  PubMed  CAS  Google Scholar 

  34. Jones TR, Humphrey PA, Brennan DC. Transplantation of vascularized allogeneic skeletal muscle for scalp reconstruction in a renal transplant patient. Transplant Proc. 1998;30:2746–2753.

    Article  PubMed  CAS  Google Scholar 

  35. Birchall M. Tongue transplantation. Lancet. 2004;363:1663.

    Article  PubMed  Google Scholar 

  36. Denton MD, Magee CC, Sayegh MH. Immunosuppressive strategies in transplantation. Lancet. 1999;353:1083–1091.

    Article  PubMed  CAS  Google Scholar 

  37. Elster EA, Xu H, Tadaki DK, et al. Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates. Transplantation. 2001;72:1473–1478.

    Article  PubMed  CAS  Google Scholar 

  38. Knechtle SJ. Treatment with immunotoxin. Philos Trans R Soc Lond B Biol Sci. 2001;356:681–689.

    Article  PubMed  CAS  Google Scholar 

  39. Spitzer TR, Delmonico F, Tolkoff-Rubin N, et al. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 1999;68:480–484.

    Article  PubMed  CAS  Google Scholar 

  40. Buncke HJ, Hoffman WY, Alpert BS, et al. Microvascular transplant of two free scalp flaps between identical twins. Plast Reconstr Surg. 1982;70:605–609.

    Article  PubMed  CAS  Google Scholar 

  41. Morris PJ, Bradley JA, Doyal L, et al. Facial transplantation: a working party report from the Royal College of Surgeons of England. Transplantation. 2004;77:330–338.

    Article  PubMed  Google Scholar 

  42. Ozer K, Izycki D, Zielinski M, et al. Development of donor-specific chimerism and tolerance in composite tissue allografts under alphabeta-T-cell receptor monoclonal antibody and cyclosporine a treatment protocols. Microsurgery. 2004;24:248–254.

    Article  PubMed  Google Scholar 

  43. Siemionow M, Izycki DM, Zielinski M. Donor-specific tolerance in fully major histocompatibility major histocompatibility complex-mismatched limb allograft transplants under an anti-alphabeta T-cell receptor monoclonal antibody and cyclosporine A protocol. Transplantation. 2003;76:1662–1668.

    Article  PubMed  CAS  Google Scholar 

  44. Ozer K, Gurunluoglu R, Zielinski M, et al. Extension of composite tissue allograft survival across major histocompatibility barrier under short course of anti-lymphocyte serum and cyclosporine a therapy. J Reconstr Microsurg. 2003;19:249–56.

    Article  PubMed  Google Scholar 

  45. Ozer K, Oke R, Gurunluoglu R, et al. Induction of tolerance to hind limb allografts in rats receiving cyclosporine A and antilymphocyte serum: effect of duration of the treatment. Transplantation. 2003;75:31–36.

    Article  PubMed  CAS  Google Scholar 

  46. Siemionow M, Oke R, Ozer K, et al. Induction of donor-specific tolerance in rat hind-limb allografts under anti-lymphocyte serum and cyclosporine A protocol. J Hand Surg [Am]. 2002;27:1095–1103.

    Article  Google Scholar 

  47. Siemionow M, Ortak T, Izycki D, et al. Induction of tolerance in composite-tissue allografts. Transplantation. 2002;15:1211–1217.

    Article  Google Scholar 

  48. Siemionow M, Ozer K. Advances in composite tissue allograft transplantation as related to the hand and upper extremity. J Hand Surg [Am]. 2002;27:565–568.

    Article  Google Scholar 

  49. Siemionow M, Gozel-Ulusal B, Ulusal A, et al. Functional tolerance following face transplantation in the rat. Transplantation. 2003;75:1607–1609.

    Article  PubMed  Google Scholar 

  50. Ulusal BG, Ulusal AE, Ozmen S, et al. A new composite facial and scalp transplantation model in rats. Plast Reconstr Surg. 2003;112:1302–1311.

    Article  PubMed  Google Scholar 

  51. Demir Y, Ozmen S, Klimczak A, et al. Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg. 2004;114:1790–1801.

    Article  PubMed  Google Scholar 

  52. Demir Y, Ozmen S, Klimczak A, et al. The efficacy of different immunosuppressive treatment protocols on survival and development of chimerism in vascularized skin allograft transplants across MHC barrier. Plast Reconstr Surg. (In press).

    Google Scholar 

  53. Unal S, Agaoglu G, Siemionow M. New surgical approach in facial transplantation extends survival of allograft recipients. Ann Plast Surg. In press.

    Google Scholar 

  54. Bermudez LE, Santamaria A, Romero T, et al. Experimental model of facial transplant. Plast Reconstr Surg. 2002;110:1374–1375.

    Article  Google Scholar 

  55. Siemionow M, Unal S, Agaoglu G, et al. What are alternative sources for total facial defect coverage? A cadaver study in preparation for facial allograft transplantation in humans-part I. Plast Reconstr Surg. In press.

    Google Scholar 

  56. Siemionow S, Agaoglu G, Unal S. Mock facial transplantation a cadaver study in preparation for facial allograft transplantation in humans, part II. Plast Reconstr Surg. In press.

    Google Scholar 

  57. Gorantla VS, Barker JH, Jones JW Jr, et al. Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery. 2000;20:420–429.

    Article  PubMed  CAS  Google Scholar 

  58. Cendales L, Hardy MA. Immunologic considerations in composite tissue transplantation: overview. Microsurgery. 2000;20:412–419.

    Article  PubMed  CAS  Google Scholar 

  59. Jones JW Jr, Ustuner ET, Zdichavsky M, et al. Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. Surgery. 1999;126:384–388.

    Article  PubMed  Google Scholar 

  60. Ustuner ET, Zdichavsky M, Ren X, et al. Long-term composite tissue allograft survival in a porcine model with cyclosporine/mycophenolate mofetil therapy. Transplantation. 1998;66:1581–1587.

    Article  PubMed  CAS  Google Scholar 

  61. Lee WP, Rubin JP, Cober S, et al. Use of swine model in transplantation of vascularized skeletal tissue allografts. Transplant Proc. 1998;30:2743–2745.

    Article  PubMed  CAS  Google Scholar 

  62. Stark GB, Swartz WM, Narayanan K, et al. Hand transplantation in baboons. Transplant Proc. 1987;19:3968–3971.

    PubMed  CAS  Google Scholar 

  63. Hovius SE, Stevens HP, van Nierop PW, et al. Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. technical aspects. Plast Reconstr Surg. 1992;89:700–709.

    Article  PubMed  CAS  Google Scholar 

  64. Miller LW. Cardiovascular toxicities of immunosuppressive agents. Am J Transplantation. 2002;2:807–818.

    Article  CAS  Google Scholar 

  65. Euvrard S, Kanitakis J, Claudy A. Skin cancer after organ transplantation. N Engl J Med. 2003;343:1681–1691.

    Article  Google Scholar 

  66. Jost SC, Doolabh VB, Mackinnon SE, et al. Acceleration of peripheral nerve regeneration following FK506 administration. Restor Neurol Neurosci. 2000;17:39–44.

    PubMed  CAS  Google Scholar 

  67. Siemionow M, Ozmen S, Demir Y. Prospects for facial allograft transplantation in humans. Plast Reconstr Surg. 2004;113:1421–1428.

    Article  PubMed  Google Scholar 

  68. Petit F, Paraskevas A, Minns AB, et al. Face transplantation: where do we stand? Plast Reconstr Surg. 2004;113:1429–1433.

    Article  PubMed  Google Scholar 

  69. Ziegelmann J, Griva K, Hankins M, et al. The transplant effects questionnaire; the development of a questionnaire for assessing the multidimensional outcome of organ transplantation—example of end stage renal disease (ESRD). Br J Health Psychol. 2000;7:393–408.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag London Limited

About this chapter

Cite this chapter

Siemionow, M.Z., Agaoglu, G. (2006). Perspectives for Facial Allograft Transplantation in Humans. In: Siemionow, M.Z. (eds) Tissue Surgery. New Techniques in Surgery Series, vol 1. Springer, London. https://doi.org/10.1007/1-84628-128-8_10

Download citation

  • DOI: https://doi.org/10.1007/1-84628-128-8_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-970-8

  • Online ISBN: 978-1-84628-128-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics