Growth Out of Control


Since 1948,the early detection of cancer has been a major goal of nuclear medicine.The direction of research has been to develop tracers that accumulate in cancer cells because of their biochemical or immunological properties.Another approach has been to detect cancerous lesions because they produce defects in normal processes,such as phagocytosis in the liver or regional blood flow in the lung.In 1975,among the first agents was selenium-75 selenomethionine,an amino acid that accumulates during the process of protein synthesis.This tracer did not achieve widespread clinical use because of the high body background and slow accumulation in the lesions.The same was true for iodine-125-iodoquine,a chloroquine analogue,and indium-111 or cobalt-57 bleomycin,all developed in 1975.


Thyroid Cancer Bone Metastasis Cancerous Lesion Detect Bone Metastasis Positron Emission Tomo 
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© Springer-Verlag London Limited 2006

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