Skip to main content
SpringerLink
Log in

Medical Management of GERD: Algorithms and Outcomes

  • Chapter
Book cover Managing Failed Anti-Reflux Therapy

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tuttle SG, Rufin F, Bettarello A. The physiology of heartburn. Ann Intern Med 1961;55:292–300.

    PubMed  CAS  Google Scholar 

  2. Orr W. Sleep issues in gastroesophageal reflux disease: beyond simple heartburn control. Rev Gastroenterol Disord 2003;3(suppl 4):S22–S29.

    PubMed  Google Scholar 

  3. Orr W. Sleep and gastroesophageal reflux disease: a wake-up call. Rev Gastroenterol Disord 2004;4(suppl 4): S25–S32.

    PubMed  Google Scholar 

  4. Katzka D, Castell DO. Lifestyle modifications. In: Castell DO, Richter JE, eds. The Esophagus. Boston: Little Brown and Co.; 1995:505–514.

    Google Scholar 

  5. Katz LC, Just R, Castell DO. Body position affects recumbent postprandial reflux. J Clin Gastroenterol 1994; 18:280–284.

    PubMed  CAS  Google Scholar 

  6. Van Herwaarden MA, Katzka DA, Smout AJ, Samsom M, Gideon M, Castell DO. Effect of different recumbent positions on postprandial reflux in normal subjects. Am J Gastroenterol 2000;95:2731–2735.

    Article  PubMed  Google Scholar 

  7. Wildi SM, Tutuian R, Castell DO. The influence of rapid food intake on postprandial reflux: studies in healthy volunteers. Am J Gastroenterol 2004;99:1645–1651.

    PubMed  Google Scholar 

  8. Katz PO. Medical management of GERD. In: Castell DO, Richter J, eds. The Esophagus. Philadelphia: Lippincott Williams & Wilkins; 2004:460–479.

    Google Scholar 

  9. Klinkenberg-Knol EC, Festen HPM. Pharmacological management of gastro-oesophageal reflux disease. Drugs 1995;49:695–710.

    Article  PubMed  CAS  Google Scholar 

  10. Mittal RK. Pathophysiology of gastroesophageal reflux disease: motility factors. In: Castell DO, Richter J, eds. The Esophagus. Philadelphia: Lippincott Williams & Wilkins; 2004:407–420.

    Google Scholar 

  11. Ramirez B, Richter JE. Review article: promotility drugs in the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1993;7:5–20.

    PubMed  CAS  Google Scholar 

  12. Blackewell JN, Heading RC, Fettes MR. Effects of Domperidone on Lower Oesophageal Sphincter Pressure and Gastroesophageal Reflux in Patients with Peptic Esophagitis. Progress with Domperidone. International Congress and Symposium Series. Vol 36. London: Royal Society of Medicine Press; 1981:57–66.

    Google Scholar 

  13. Vigneri S, Temini R, Leandro G, et al. A comparison of five maintenance therapies for reflux esophagitis. N Engl J Med 1995;333:1106–1111.

    Article  PubMed  CAS  Google Scholar 

  14. Sontag SJ. Rolling review: gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1993;7:293–312.

    PubMed  CAS  Google Scholar 

  15. Chiba, et al. Gastroenterology 1996.

    Google Scholar 

  16. Johnson DA, Ryan M,Wootton, et al. Comparative study of esomeprazole and lansoprazole for intragastric pH analysis in patients with symptoms of gastroesophageal reflux disease. Gut 2004;56:113.

    Google Scholar 

  17. Johnson DA. Evidence-based assessment of the efficacy of esomeprazole for the healing of erosive esophagitis. Expert Rev Pharmacoeconomics Outcomes Res 2004; 4(4):371–382.

    Article  Google Scholar 

  18. Sharma VK, Leontiadis GI, Howden CW. Meta-analysis of randomized controlled trials comparing standard clinical doses of omeprazole and lansoprazole in erosive esophagitis. Aliment Pharmacol Ther 2001;15:227-231.

    Google Scholar 

  19. Peghini PL, Katz PO, Bracy NA, et al. Nocturnal recovery of gastric acid secretion with twice daily dosing of proton pump inhibitors. Am J Gastroenterol 1998; 93:763–767.

    Article  PubMed  CAS  Google Scholar 

  20. Fackler WK, Ours TM, Vaezi MF, et al. Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough. Gastroenterology 2002;122:625–632.

    Article  PubMed  CAS  Google Scholar 

  21. Maton P. Efficacy and safety of GERD pharmacotherapy. In: Richter JE, ed. Healing Horizons in Acid Reflux Disease. Cleveland: Cleveland Clinic Foundation; 2003: 183–212.

    Google Scholar 

  22. Smith PM, Kerr GD, Cockel R, et al. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Restore Investigator Group. Gastroenterology 1994;197:1312–1318.

    Google Scholar 

  23. Swarbrick ET, Gough AL, Foster CS, Christian J, Garrett AD, Langworthy CH. Prevention of recurrence of esophageal stricture: a comparison of lansoprazole and high dose ranitidine. Eur J Gastroenterol Hepatol 1996; 8:431–438.

    PubMed  CAS  Google Scholar 

  24. Marks RD, Richter JE, Rizzo J, et al. Omeprazole vs H2 receptor antagonist in treating patients with peptic stricture and esophagitis. Gastroenterology 1994;106: 907–915.

    PubMed  CAS  Google Scholar 

  25. Lauritsen K, Deviere J, Bigard MA, et al. Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis. Aliment Pharmacol Ther 2003;17: 333–341.

    PubMed  CAS  Google Scholar 

  26. Klinkenberg-Knol EC, Nelis F, Dent J, et al. Long term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety and influence on gastric mucosa. Gastroenterology 2000;118:661–669.

    PubMed  CAS  Google Scholar 

  27. Sampliner RE. Effect of up to 3 yrs of high-dose lansoprazole on Barrett’s esophagus. Am J Gastroenterol 1994; 89:1844–1848.

    PubMed  CAS  Google Scholar 

  28. Peters FT, Ganesh S, Kuipers EJ, et al. Endoscopic regression of Barrett’s oesophagus during omeprazole treatment: a randomized double blind study. Gut 1999;45: 485–494.

    Article  Google Scholar 

  29. Sampliner RE, Camargo L, Fass R. Impact of esophageal acid exposure on the endoscopic reversal of Barrett’s esophagus. Am J Gastroenterol 2002;97:270–272.

    PubMed  Google Scholar 

  30. Sharma P, Sampliner RE, Carmargo E. Normalization of esophageal pH with high dose proton pump inhibitor therapy does not result in regression of Barrett’s esophagus. Am J Gastroenterol 1997;92:582–585.

    PubMed  CAS  Google Scholar 

  31. Morris CD, Armstrong GR, Bigley G, et al. Cyclooxygenase-2 expression in the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence. Am J Gastroenterol 2001; 96:990–996.

    PubMed  CAS  Google Scholar 

  32. Shirvani VN, Ouatu-Lascar R, Kaur BS, et al. Cyclooxygenase 2 expression in Barrett’s esophagus and adenocarcinoma: ex vivo induction by bile salts and acid exposure. Gastroenterology 2000;118:487–496.

    Article  PubMed  CAS  Google Scholar 

  33. Ouatu-Lascar R, Fitzgerald RC, Triadafilopoulos G. Differentiation and proliferation in Barrett’s esophagus and the effects of acid suppression. Gastroenterology 1999;117:327–335.

    PubMed  CAS  Google Scholar 

  34. Shirvani VN, Ouatu-Lascar R, Kaur BS, et al. Cyclooxygenase 2 expression by bile salts and acid exposure. Gastroenterology 2000;118(3):487–496.

    Article  PubMed  CAS  Google Scholar 

  35. El-Serag HB, Aguiree TV, Davis S, et al. Proton pump inhibitors are associated with reduced incidence of dysplasia in Barrett’s esophagus. Am J Gastroenterol 2004; 99:1877–1883.

    PubMed  CAS  Google Scholar 

  36. Spechler SJ, Lee E, Ahnen D, et al. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA 2001;285:2331–2338.

    Article  PubMed  CAS  Google Scholar 

  37. Parrilla P, Martinez de Haro LF, Ortiz A, et al. Long-term results of a randomized perspective study comparing medical and surgical treatment of Barrett’s esophagus. Ann Surg 2003;237:291–298.

    PubMed  Google Scholar 

  38. Harding S, Richter JE, Guzzo MR, et al. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med 1996;100:395–405.

    Article  PubMed  CAS  Google Scholar 

  39. Field SK, Sutherland LR. Does medical anti-reflux therapy improve asthma in asthmatics with gastrooesophageal reflux? Chest 1998;114:275–283.

    PubMed  CAS  Google Scholar 

  40. Field SK, Gelfand GA, McFadden SD. The effects of anti-reflux surgery on asthmatics with gastroesophageal reflux. Chest 1999;116:766–774.

    Article  PubMed  CAS  Google Scholar 

  41. So JB, Zeitels SM, Rattner DW. Outcomes of atypical symptoms attributed to gastroesophageal reflux treated by laparoscopic fundoplication. Surgery 1998;124:28–32.

    PubMed  CAS  Google Scholar 

  42. Weusten B, Smout AJPM. Ambulatory monitoring of esophageal pH and pressure. In: Castell DO, Richter J, eds. The Esophagus. Philadelphia: Lippincott Williams & Wilkins; 2004:135–164.

    Google Scholar 

  43. Kahrilas PJ, Quigley EM. Clinical esophageal pH monitoring: a technical review of practice guideline development. Gastroenterology 1996;110:1982–1986.

    Article  PubMed  CAS  Google Scholar 

  44. Pandolfino JE, Richer JE, Ours T, et al. Ambulatory esophageal pH monitoring using a wireless system. Am J Gastroenterol 2003;98(4):740–749.

    Article  PubMed  Google Scholar 

  45. Grande L, Pujol A, Ros E, et al. Intraesophageal pH monitoring after breakfast and lunch in gastroesophageal reflux disease. J Clin Gastroenterol 1988;10: 373–376.

    PubMed  CAS  Google Scholar 

  46. Jorgensen F, Elsborg L, Hessse B. The diagnostic value of computerized short term esophageal pH monitoring in suspected gastroesophageal reflux. Scand J Gastroenterol 1988;23:363–367.

    PubMed  CAS  Google Scholar 

  47. Bianchi Porro G, Pace F. Comparison of three methods of intraesophageal pH recording in the diagnosis of gastroesophageal reflux. Scand J Gastroenterol 1988;23: 363–367.

    Google Scholar 

  48. Clark CS, Kraus BB, Sinclair J, et al. Gastroesophageal reflux induced by exercise in healthy volunteers. JAMA 1989;261:3599–3601.

    Article  PubMed  CAS  Google Scholar 

  49. Johnsson F, Joelsson B. Reproducibility of ambulatory esophageal pH monitoring in the diagnosis of gastroesophageal pH monitoring. Gut 1988;33:1127–1133.

    Google Scholar 

  50. Schindlbeck NE, Heinrich C, Konig A, Dendorfer A, Pace F, Muller-Lissner SA. Optimal thresholds, sensitivity,and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease. Gastroenterology 1987; 93:85–90.

    PubMed  CAS  Google Scholar 

  51. Wang H, Beck IT, Paterson WG. Reproducibility and physiologic characteristics of 24-hour ambulatory esophageal manometry/pH-metry. Am J Gastroenterol 1996;91:493–497.

    Google Scholar 

  52. Vandeplas Y, Helven R, Goyvaerts H, Sacre L. Reproducibility of continuous 24 hour oesophageal pH monitoring in infants and children. Gut 1990;31:374–377.

    Google Scholar 

  53. Murphy DW, Yuan Y, Castell DO. Does the intraesophageal pH probe accurately detect acid reflux? Simultaneous recording with two pH probes in humans. Dig Dis Sci 1989;34:649–656.

    PubMed  CAS  Google Scholar 

  54. Katzka DA, Castell DO. Successful elimination of reflux symptoms does not ensure adequate control of acid reflux in Barrett’s esophagus. Am J Gastroenterol 1994; 89:989–991.

    PubMed  CAS  Google Scholar 

  55. Ouatu-Lascar R, Triadafilopoulos G. Complete elimination of reflux symptoms does not guarantee normalization of intraesophageal acid reflux in patients with Barrett’s esophagus. Am J Gastroenterol 1998;93: 711–716.

    Article  PubMed  CAS  Google Scholar 

  56. Fass R, Sampliner RE, Malagon IB, et al. Failure of oesophageal acid control in candidates for Barrett’s oesophagus reversal on a very high dose of proton pump inhibitor. Aliment Pharmacol Ther 2000;14:597–602.

    PubMed  CAS  Google Scholar 

  57. Gerson LB, Bopariai V, Ullah N, Triadafilopoulos G. Oesophageal and gastric pH profiles in patients with gastro-oesophageal reflux disease and Barrett’s oesophagus treated with proton pump inhibitors. Aliment Pharmacol Ther 2004;20:637–643.

    Article  PubMed  CAS  Google Scholar 

  58. Lundell LR. Surgical treatment of gastroesophageal reflux disease. In: Castell DO, Richter JE, eds. The Esophagus. Philadelphia: Lippincottt Williams & Wilkins; 2004:564–571.

    Google Scholar 

  59. Dent J, Holloway RH, Toouli J, et al. Mechanisms of lower esophageal sphincter incompetence in patients with symptomatic gastroesophageal reflux. Gut 1988;29: 1020–1024.

    PubMed  CAS  Google Scholar 

  60. Mittal RK, Holloway RH, Penagini R, et al. Transient lower esophageal sphincter relaxation. Gastroenterology 1995;109:601–606.

    PubMed  CAS  Google Scholar 

  61. Maton P. Efficacy and safety of GERD pharmacotherapy. In: Richter JE, ed. Healing Horizons in Acid Reflux Disease. Cleveland: Cleveland Clinic Foundation; 2003: 183–212.

    Google Scholar 

  62. Younes Z, Johnson DA. Diagnostic evaluation in gastroesophageal reflux disease. Gastroenterol Clin North Am 1999;28:809–830.

    Article  PubMed  CAS  Google Scholar 

  63. Winters C, Spurling TJ, Chobanian SJ, et al. Barrett’s esophagus: a prevalent complication of gastroesophageal gastroesophageal reflux disease. Gastroenterology 1987;92: 118–124.

    PubMed  Google Scholar 

  64. DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroeosphageal reflux disease. Am J Gastroenterol 2005;100(1):190–200.

    Article  PubMed  Google Scholar 

  65. Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. 1997;92:1293–1297.

    Google Scholar 

  66. Johnson DA. GERD treatment protocol. In: Richter JE, ed. Healing Horizons in Acid Reflux Disease. Cleveland: Cleveland Clinic Foundation; 2003:247–274.

    Google Scholar 

  67. Carlsson R, Dent J, Bolling-Sternevald E, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 1998;33:1023–1029.

    PubMed  CAS  Google Scholar 

  68. Bytzer P. Assessment of reflux symptom severity: methodological options and their attributes. Gut 2004; 53(suppl IV):iv28–iv34.

    PubMed  Google Scholar 

  69. Bytzer P. Goals of therapy and guidelines for treatment success in symptomatic gastroesophageal reflux disease patients. Am J Gastroenterol 2003;98(suppl): S31–S39.

    PubMed  Google Scholar 

  70. Guyatt G, Berman LB, Townsend M, et al. Should study subjects see their previous responses. J Chronic Dis 1985;38:1003–1007.

    PubMed  CAS  Google Scholar 

  71. Revicki DA, Crawley JA, Zodet MW, et al. Complete resolution of heartburn symptoms and health related quality of life in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 1999;13:1621–1630.

    Article  PubMed  CAS  Google Scholar 

  72. Junghard O, Wiklund IK. A comparison of patient and clinician ratings of heartburn. Gastroenterology 2003; 124(4 suppl 1):A541.

    Google Scholar 

  73. McColl E. Best practice in symptom assessment: a review. Gut 2004;53(suppl 53 IV):iv49–iv54.

    PubMed  Google Scholar 

  74. Sharma N, Donnellan C, Preston C, et al. A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials. Gut 2004;53(suppl IV):58–65.

    Google Scholar 

  75. McColl E. Best practice in symptom assessment: a review. Gut 2004;53(suppl IV):49–54.

    Google Scholar 

  76. Irvine EJ. Quality of life assessment in gastrooesophageal reflux disease. Gut 2004;53(suppl IV): iv35–iv39.

    PubMed  Google Scholar 

  77. Fernando HC, Aschauer PR, Rosenblatt M, et al. Quality of life after anti-reflux surgery compared with nonoperative management of severe gastro-esophageal reflux disease. Am Coll Surg 2002;194:23–27.

    Google Scholar 

  78. Velanovich V. Using quality-of-life measurements to predict patient satisfaction outcomes for anti-reflux surgery. Arch Surg 2004;139(6):621–625.

    PubMed  Google Scholar 

  79. Irvine EJ. Quality of life assessment in gastrooesophageal reflux disease. Gut 2004;53(suppl IV): 35–39.

    Google Scholar 

Download references

Authors
  1. David A. Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Professor of Surgery, Head, Thoracic Surgery Service, Department of Surgery, University of Chicago, Chicago, IL, USA

    Mark K. Ferguson MD

  2. Professor of Medicine, Division of Gastroenterology, Department of Medicine, Oregon Health & Science University, Portland, OR, USA

    M. Brian Fennerty MD

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag London Limited

About this chapter

Cite this chapter

Johnson, D.A. (2006). Medical Management of GERD: Algorithms and Outcomes. In: Ferguson, M.K., Fennerty, M.B. (eds) Managing Failed Anti-Reflux Therapy. Springer, London. https://doi.org/10.1007/1-84628-011-7_3

Download citation

  • DOI: https://doi.org/10.1007/1-84628-011-7_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-909-8

  • Online ISBN: 978-1-84628-011-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation