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Thyroid Anatomy and Physiology

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Management of Thyroid Cancer and Related Nodular Disease

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References

  1. Stone JA, Figueroa RE. Embryology and anatomy of the neck. Neuroimaging Clin N Am. 2000;10(1):55–73, viii.

    PubMed  CAS  Google Scholar 

  2. Van Vliet G. Development of the thyroid gland: lessons from congenitally hypothyroid mice and men. Clin Genet. 2003;63(6):445–55.

    Article  PubMed  Google Scholar 

  3. Li Volsi V. What you always wanted to know about thyroid pathology. Surgical Pathology of the Thyroid. Philadelphia: Saunders; 1990; 403–7.

    Google Scholar 

  4. Kang HC. Lingual thyroid: marked response to suppression therapy. Thyroid. 2004;14(5):401–2.

    Article  PubMed  Google Scholar 

  5. Gallo A, Leonetti F, Torri E, Manciocco V, Simonelli M, DeVincentiis M. Ectopic lingual thyroid as unusual cause of severe dysphagia. Dysphagia. 2001;16(3): 220–3.

    Article  PubMed  CAS  Google Scholar 

  6. Bayram F, Kulahli I, Yuce I, Gokce C, Cagli S, Deniz K. Functional lingual thyroid as unusual cause of progressive dysphagia. Thyroid. 2004;14(4):321–4.

    Article  PubMed  CAS  Google Scholar 

  7. Park HM, Gupta S, Skierczynski P. Radioiodine-131 therapy for lingual thyroid. Thyroid. 2003;13(6):607.

    Article  PubMed  Google Scholar 

  8. Rojananin S, Ungkanont K. Transposition of the lingual thyroid: a new alternative technique. Head Neck. 1999; 21(5):480–3.

    Article  PubMed  CAS  Google Scholar 

  9. Massine RE, Durning SJ, Koroscil TM. Lingual thyroid carcinoma: a case report and review of the literature. Thyroid. 2001;11(12):1191–6.

    Article  PubMed  CAS  Google Scholar 

  10. Goldstein B, Westra WH, Califano J. Multifocal papillary thyroid carcinoma arising in a lingual thyroid: a case report. Arch Otolaryngol Head Neck Surg. 2002; 128(10):1198–200.

    PubMed  Google Scholar 

  11. Peretz A, Leiberman E, Kapelushnik J, Hershkovitz E. Thyroglossal duct carcinoma in children: case presentation and review of the literature. Thyroid 2004; 14(9):777–85.

    Article  PubMed  Google Scholar 

  12. Sackett WR, Reeve TS, Barraclough B, Delbridge L. Thyrothymic thyroid rests: incidence and relationship to the thyroid gland. J Am Coll Surg. 2002;195(5): 635–40.

    Article  PubMed  Google Scholar 

  13. Pollice L, Caruso G. Struma cordis. Ectopic thyroid goiter in the right ventricle. Arch Pathol L ab Med. 1986;110(5):452–3.

    CAS  Google Scholar 

  14. Rieser GD, Ober KP, Cowan RJ, Cordell AR. Radioiodide imaging of struma cordis. Clin Nucl Med. 1988; 13(6):421–2.

    Article  PubMed  CAS  Google Scholar 

  15. Baykut D, Fiegen U, Krian A, Thiel A. Ectopic thyroid tissue in the left ventricular outflow tract. Ann Thorac Surg. 2000;69(2):620–1.

    Article  PubMed  CAS  Google Scholar 

  16. Khan A, Nose V. Pathology of the thyroid gland. Endocrine pathology. Differential diagnosis and molecular advances. Totowa, NJ: Humana Press; 2004;153–89.

    Google Scholar 

  17. Bone R, Biller, HF, Irwin, TM. Intralaryngtracheal thyroid. Ann Otol. 1972;81:424–8.

    CAS  Google Scholar 

  18. Gauger PG, Delbridge LW, Thompson NW, Crummer P, Reeve TS. Incidence and importance of the tubercle of Zuckerkandl in thyroid surgery. Eur J Surg. 2001; 167(4):249–54.

    Article  PubMed  CAS  Google Scholar 

  19. Haigh PI, Giuliano AE. Sentinel lymph node dissection for thyroid malignancy. Recent Results Cancer Res. 2000;157:201–5.

    PubMed  CAS  Google Scholar 

  20. Stoeckli SJ, Pfaltz M, Steinert H, Schmid S. Sentinel lymph node biopsy in thyroid tumors: a pilot study. Eur Arch Otorhinolaryngol. 2003;260(7):364–8.

    Article  PubMed  Google Scholar 

  21. Catarci M, Zaraca F, Angeloni R, et al. Preoperative lymphoscintigraphy and sentinel lymph node biopsy in papillary thyroid cancer. A pilot study. J Surg Oncol. 2001;77(1):21–4; discussion 5.

    Article  PubMed  CAS  Google Scholar 

  22. Page C, Foulon P, Strunski V. The inferior laryngeal nerve: surgical and anatomic considerations. Report of 251 thyroidectomies. Surg Radiol Anat. 2003;25(3–4): 188–91.

    Article  PubMed  CAS  Google Scholar 

  23. Fewins J, Simpson CB, Miller FR. Complications of thyroid and parathyroid surgery. Otolaryngol Clin North Am. 2003;36(1):189–206, x.

    Article  PubMed  Google Scholar 

  24. Delbridge L, Samra J. Editorial: the “eglected” nerve in thyroid surgery—the case for routine identification of the external laryngeal nerve. ANZ J Surg. 2002;72(3):239.

    Google Scholar 

  25. Delbridge L. Total thyroidectomy: the evolution of surgical technique. ANZ J Surg. 2003;73(9):761–8.

    Article  PubMed  Google Scholar 

  26. Miller FR. Surgical anatomy of the thyroid and parathyroid glands. Otolaryngol Clin North Am. 2003;36(1): 1–7, vii.

    Article  PubMed  Google Scholar 

  27. Page C, Laude M, Legars D, Foulon P, Strunski V. The external laryngeal nerve: surgical and anatomic considerations. Report of 50 total thyroidectomies. Surg Radiol Anat. 2004;26(3):182–5.

    Article  PubMed  CAS  Google Scholar 

  28. Gauger PG, Reeve TS, Wilkinson M, Delbridge LW. Routine parathyroid autotransplantation during total thyroidectomy: the influence of technique. Eur J Surg. 2000;166(8):605–9.

    Article  PubMed  CAS  Google Scholar 

  29. Harding JL, Sywak MS, Sidhu S, Delbridge LW. Horner’s syndrome in association with thyroid and parathyroid disease. ANZ J Surg. 2004;74(6):442–5.

    Article  PubMed  Google Scholar 

  30. Busnardo B, Nacamulli D, Frigato F, et al. Normal values for thyroid ultrasonography, goiter prevalence and urinary iodine concentration in schoolchildren of the Veneto Region, Italy. J Endocrinol Invest. 2003;26(10): 991–6.

    PubMed  CAS  Google Scholar 

  31. Schmutzler C. Regulation of the sodium/iodide symporter by retinoids—a review. Exp Clin Endocrinol Diabetes. 2001;109(1):41–4.

    Article  PubMed  CAS  Google Scholar 

  32. World Health Organization. Micronutrient deficiencies. Online posting. 2003 Sep 3 www.who.int/nut/idd.htm.

    Google Scholar 

  33. Versloot PM, Schroder-van der Elst JP, van der Heide D, Boogerd L. Effects of marginal iodine deficiency during pregnancy: iodide uptake by the maternal and fetal thyroid. Am J Physiol. 1997;273(6 Pt 1):E1121–6.

    PubMed  CAS  Google Scholar 

  34. Bernal J. Iodine and brain development. Biofactors. 1999;10(2–3):271–6.

    PubMed  CAS  Google Scholar 

  35. Glinoer D. Pregnancy and iodine. Thyroid. 2001;11(5): 471–81.

    Article  PubMed  CAS  Google Scholar 

  36. Levy O, De la Vieja A, Carrasco N. The Na+/I-symporter (NIS): recent advances. J Bioenerg Biomembr. 1998;30(2):195–206.

    Article  PubMed  CAS  Google Scholar 

  37. Wapnir IL, van de Rijn M, Nowels K, et al. Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab. 2003;88(4):1880–8.

    Article  PubMed  CAS  Google Scholar 

  38. Ward LS, Santarosa PL, Granja F, da Assumpcao LV, Savoldi M, Goldman GH. Low expression of sodium iodide symporter identifies aggressive thyroid tumors. Cancer Lett. 2003;200(1):85–91.

    Article  PubMed  CAS  Google Scholar 

  39. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996; 379(6564):458–60.

    Article  PubMed  CAS  Google Scholar 

  40. Rudnicka L, Sinczak A, Szybinski P, Huszno B, Stachura J. Expression of the Na(+)/I(-) symporter in invasive ductal breast cancer. Folia Histochem Cytobiol. 2003; 41(1):37–40.

    PubMed  CAS  Google Scholar 

  41. Spitzweg C, Dutton CM, Castro MR, et al. Expression of the sodium iodide symporter in human kidney. Kidney Int. 2001;59(3):1013–23.

    Article  PubMed  CAS  Google Scholar 

  42. Spitzweg C, Joba W, Heufelder AE. Expression of thyroid-related genes in human thymus. Thyroid. 1999;9(2):133–41.

    PubMed  CAS  Google Scholar 

  43. Dohan O, Carrasco N. Advances in Na(+)/I(-) symporter (NIS) research in the thyroid and beyond. Mol Cell Endocrinol. 2003;213(1):59–70.

    Article  PubMed  CAS  Google Scholar 

  44. Smanik PA, Liu Q, Furminger TL, et al. Cloning of the human sodium lodide symporter. Biochem Biophys Res Commun. 1996;226(2):339–45.

    Article  PubMed  CAS  Google Scholar 

  45. De La Vieja A, Dohan O, Levy O, Carrasco N. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol Rev. 2000;80(3):1083–105.

    Google Scholar 

  46. Venkataraman GM, Yatin M, Ain KB. Cloning of the human sodium-iodide symporter promoter and characterization in a differentiated human thyroid cell line, KAT-50. Thyroid. 1998;8(1):63–9.

    PubMed  CAS  Google Scholar 

  47. Van Sande J, Massart C, Beauwens R, et al. Anion selectivity by the sodium iodide symporter. Endocrinology. 2003;144(1):247–52.

    Article  PubMed  CAS  Google Scholar 

  48. Zuckier LS, Dohan O, Li Y, Chang CJ, Carrasco N, Dadachova E. Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo. J Nucl Med. 2004;45(3):500–7.

    PubMed  CAS  Google Scholar 

  49. Smyth PP, Dwyer RM. The sodium iodide symporter and thyroid disease. Clin Endocrinol (Oxf) 2002;56(4): 427–9.

    Article  Google Scholar 

  50. Endo T, Kogai T, Nakazato M, Saito T, Kaneshige M, Onaya T. Autoantibody against Na+/I-symporter in the sera of patients with autoimmune thyroid disease. Biochem Biophys Res Commun. 1996;224(1):92–5.

    Article  PubMed  CAS  Google Scholar 

  51. Heufelder AE, Joba W, Morgenthaler NG. Autoimmunity involving the human sodium/iodide symporter: fact or fiction? Exp Clin Endocrinol Diabetes. 2001; 109(1):35–40.

    Article  PubMed  CAS  Google Scholar 

  52. Ajjan RA, Kemp EH, Waterman EA, et al. Detection of binding and blocking autoantibodies to the human sodium-iodide symporter in patients with autoimmune thyroid disease. J Clin Endocrinol Metab. 2000; 85(5):2020–7.

    Article  PubMed  CAS  Google Scholar 

  53. Chin HS, Chin DK, Morgenthaler NG, Vassart G, Costagliola S. Rarity of anti-Na+/I-symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD). J Clin Endocrinol Metab. 2000;85(10):3937–40.

    Article  PubMed  CAS  Google Scholar 

  54. Tonacchera M, Agretti P, de Marco G, et al. Congenital hypothyroidism due to a new deletion in the sodium/iodide symporter protein. Clin Endocrinol (Oxf). 2003; 59(4):500–6.

    Article  CAS  Google Scholar 

  55. Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999;81(5):469–76.

    Article  PubMed  CAS  Google Scholar 

  56. Tazebay U, Wapnir IL, Levy O, et al. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Med. 2000;6:871–5.

    Article  PubMed  CAS  Google Scholar 

  57. Zoeller RT. Editorial: Local control of the timing of thyroid hormone action in the developing human brain. J Clin Endocrinol Metab. 2004;89(7):3114–16.

    Google Scholar 

  58. Li GH, Post J, Koibuchi N, Sajdel-Sulkowska EM.Impact of thyroid hormone deficiency on the developing CNS: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil. Cerebellum. 2004;3(2):100–6.

    Article  PubMed  CAS  Google Scholar 

  59. Bakheet SM, Hammami MM. Patterns of radioiodine uptake by the lactating breast. Eur J Nucl Med. 1994; 21(7):604–8.

    Article  PubMed  CAS  Google Scholar 

  60. Carlisle MR, Lu C, McDougall IR. The interpretation of 131I scans in the evaluation of thyroid cancer, with an emphasis on false positive findings. Nucl Med Commun. 2003;24(6):715–35.

    Article  PubMed  CAS  Google Scholar 

  61. Dohan O, de la Vieja A, Paroder V, et al. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003;24(1): 48–77.

    Article  PubMed  CAS  Google Scholar 

  62. Spitzweg C, Morris JC. Gene therapy for thyroid cancer: current status and future prospects. Thyroid. 2004; 14(6):424–34.

    Article  PubMed  CAS  Google Scholar 

  63. Dingli D, Diaz RM, Bergert ER, O’Connor MK, Morris JC, Russell SJ. Genetically targeted radiotherapy for multiple myeloma. Blood. 2003;102(2):489–96.

    Article  PubMed  CAS  Google Scholar 

  64. Haberkorn U. Gene therapy with sodium/iodide symporter in hepatocarcinoma. Exp Clin Endocrinol Diabetes. 2001;109(1):60–2.

    Article  PubMed  CAS  Google Scholar 

  65. Mitchell AM, Manley SW, Morris JC, Powell KA, Bergert ER, Mortimer RH. Sodium iodide symporter (NIS) gene expression in human placenta. Placenta. 2001; 22(2–3):256–8.

    Article  PubMed  CAS  Google Scholar 

  66. Mian C, Lacroix L, Alzieu L, Nocera M, Talbot M, Bidart JM, Schlumberger M, Caillou B. Sodium iodide symporter and pendrin expression in human thyroid tissues. Thyroid. 2001;11(9):825–30.

    Article  PubMed  CAS  Google Scholar 

  67. Yoshida A, Taniguchi S, Hisatome I, et al. Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J Clin Endocrinol Metab. 2002;87(7):3356–61.

    Article  PubMed  CAS  Google Scholar 

  68. Russo D, Manole D, Arturi F, et al. Absence of sodium/iodide symporter gene mutations in differentiated human thyroid carcinomas. Thyroid. 2001; 11(1):37–9.

    Article  PubMed  CAS  Google Scholar 

  69. Lacroix L, Pourcher T, Magnon C, et al. Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters. J Clin Endocrinol Metab. 2004;89(3):1423–8.

    Article  PubMed  CAS  Google Scholar 

  70. Chang VW, Ho Y. Structural characterization of the mouse Foxf1a gene. Gene. 2001;267(2):201–11.

    Article  PubMed  CAS  Google Scholar 

  71. Romanelli MG, Tato L, Lorenzi P, Morandi C. Nuclear localization domains in human thyroid transcription factor 2. Biochim Biophys Acta. 2003;1643(1–3):55–64.

    PubMed  CAS  Google Scholar 

  72. Aza-Blanc P, Di Lauro R, Santisteban P. Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity. Mol Endocrinol. 1993;7(10):1297–306.

    Article  PubMed  CAS  Google Scholar 

  73. Ortiz L, Aza-Blanc P, Zannini M, Cato AC, Santisteban P. The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription. J Biol Chem. 1999;274(21):15213–21.

    Article  PubMed  CAS  Google Scholar 

  74. Sequeira M, Al-Khafaji F, Park S, et al. Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis. Thyroid. 2003;13(10): 927–32.

    Article  PubMed  CAS  Google Scholar 

  75. Fabbro D, Pellizzari L, Mercuri F, Tell G, Damante G. Pax-8 protein levels regulate thyroglobulin gene expression. J Mol Endocrinol. 1998;21(3):347–54.

    Article  PubMed  CAS  Google Scholar 

  76. Kang HC, Ohmori M, Harii N, Endo T, Onaya T. Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1. Endocrinology. 2001;142(1):267–75.

    Article  PubMed  CAS  Google Scholar 

  77. Miccadei S, De Leo R, Zammarchi E, Natali PG, Civitareale D. The synergistic activity of thyroid transcription factor 1 and Pax-8 relies on the promoter/enhancer interplay. Mol Endocrinol. 2002;16(4):837–46.

    Article  PubMed  CAS  Google Scholar 

  78. Congdon T, Nguyen LQ, Nogueira CR, Habiby RL, Medeiros-Neto G, Kopp P. A novel mutation (Q40P) in Pax-8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and child. J Clin Endocrinol Metab. 2001;86(8):3962–7.

    Article  PubMed  CAS  Google Scholar 

  79. Dunn JT, Dunn AD. Update on intrathyroidal iodine metabolism. Thyroid. 2001;11(5):407–14.

    Article  PubMed  CAS  Google Scholar 

  80. Dunn JT, Dunn AD. The importance of thyroglobulin structure for thyroid hormone biosynthesis. Biochimie. 1999;81(5):505–9.

    Article  PubMed  CAS  Google Scholar 

  81. Masini-Repiso AM, Bonaterra M, Spitale L, et al. Ultrastructural localization of thyroid peroxidase, hydrogen peroxide-generating sites, and monoamine oxidase in benign and malignant thyroid diseases. Hum Pathol. 2004;35(4):436–46.

    Article  PubMed  CAS  Google Scholar 

  82. Haberkorn U, Altmann A, Jiang S, Morr I, Mahmut M, Eisenhut M. Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene. Eur J Nucl Med. 2001;28(5):633–8.

    Article  PubMed  CAS  Google Scholar 

  83. Boland A, Magnon C, Filetti S, et al. Transposition of the thyroid iodide uptake and organification system in nonthyroid tumor cells by adenoviral vector-mediated gene transfers. Thyroid. 2002;12(1):19–26.

    Article  PubMed  CAS  Google Scholar 

  84. Nascimento AC, Guedes DR, Santos CS, Knobel M, Rubio IG, Medeiros-Neto G. Thyroperoxidase gene mutations in congenital goitrous hypothyroidism with total and partial iodide organification defect. Thyroid. 2003;13(12):1145–51.

    Article  PubMed  CAS  Google Scholar 

  85. Gray H, Greig WR, Hooper LA, McDougall IR. A twenty minute perchlorate discharge test. J Clin Endocrinol Metab. 1972;34:594–6.

    PubMed  CAS  Google Scholar 

  86. Bakker B, Bikker H, Vulsma T, de Randamie JS, Wiedijk BM, De Vijlder JJ. Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). J Clin Endocrinol Metab. 2000;85(10):3708–12.

    Article  PubMed  CAS  Google Scholar 

  87. Moreno JC, Bikker H, Kempers MJ, et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med. 2002; 347(2):95–102.

    Article  PubMed  CAS  Google Scholar 

  88. Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(4):1433–41.

    Article  PubMed  CAS  Google Scholar 

  89. Lee JY, Uzuka Y, Tanabe S, Sarashina T. Prevalence of thyroglobulin autoantibodies detected by enzymelinked immunosorbent assay of canine serum in hypothyroid, obese and healthy dogs in Japan. Res Vet Sci. 2004;76(2):129–32.

    Article  PubMed  CAS  Google Scholar 

  90. Gillam MP, Kopp P. Genetic defects in thyroid hormone synthesis. Curr Opin Pediatr. 2001;13(4): 364–72.

    Article  PubMed  CAS  Google Scholar 

  91. Moreno JC, de Vijlder JJ, Vulsma T, Ris-Stalpers C. Genetic basis of hypothyroidism: recent advances, gaps and strategies for future research. Trends Endocrinol Metab. 2003;14(7):318–26.

    Article  PubMed  CAS  Google Scholar 

  92. Lisi S, Pinchera A, McCluskey RT, et al. Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Proc Natl Acad Sci USA. 2003;100(25): 14858–63.

    Article  PubMed  CAS  Google Scholar 

  93. Palha JA. Transthyretin as a thyroid hormone carrier: function revisited. Clin C hem L ab Med. 2002;40(12): 1292–300.

    CAS  Google Scholar 

  94. Abe T, Suzuki T, Unno M, Tokui T, Ito S. Thyroid hormone transporters: recent advances. Trends Endocrinol Metab. 2002;13(5):215–20.

    Article  PubMed  CAS  Google Scholar 

  95. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev. 2001; 22(4):451–76.

    Article  PubMed  CAS  Google Scholar 

  96. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003;278(41):40128–35.

    Article  PubMed  CAS  Google Scholar 

  97. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002;16(10): 2283–96.

    Article  PubMed  CAS  Google Scholar 

  98. Fujiwara K, Adachi H, Nishio T, et al. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001;142(5):2005–12.

    Article  PubMed  CAS  Google Scholar 

  99. Ritchie JW, Shi YB, Hayashi Y, et al. A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors. Mol Endocrinol. 2003; 17(4):653–61.

    Article  PubMed  CAS  Google Scholar 

  100. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001;81(3):1097–142.

    PubMed  CAS  Google Scholar 

  101. Bassett JH, Harvey CB, Williams GR. Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions. Mol Cell Endocrinol. 2003;213(1):1–11.

    Article  PubMed  CAS  Google Scholar 

  102. Quack M, Carlberg C. Single thyroid hormone receptor monomers are competent for co-activatormediated transactivation. Biochem J. 2001;360 (Pt 2): 387–93.

    Article  PubMed  CAS  Google Scholar 

  103. Viguerie N, Langin D. Effect of thyroid hormone on gene expression. Curr Opin Clin Nutr Metab Care. 2003;6(4):377–81.

    Article  PubMed  CAS  Google Scholar 

  104. Davis PJ, Davis FB. Nongenomic actions of thyroid hormone. Thyroid. 1996;6(5):497–504.

    Article  PubMed  CAS  Google Scholar 

  105. Davis PJ, Davis FB. Nongenomic actions of thyroid hormone on the heart. Thyroid. 2002;12(6):459–66.

    Article  PubMed  CAS  Google Scholar 

  106. Goglia F, Silvestri E, Lanni A. Thyroid hormones and mitochondria. Biosci Rep. 2002;22(1):17–32.

    Article  PubMed  CAS  Google Scholar 

  107. Shibusawa N, Hashimoto K, Nikrodhanond AA, et al. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003;112(4):588–97.

    Article  PubMed  CAS  Google Scholar 

  108. Hudecova S, Vadaszova A, Soukup T, Krizanova O. Effect of thyroid hormones on the gene expression of calcium transport systems in rat muscles. Life Sci. 2004;75(8):923–31.

    Article  PubMed  CAS  Google Scholar 

  109. Refetoff S. The syndrome of generalized resistance to thyroid hormone (GRTH). Endocr Res. 1989;15(4): 717–43.

    Article  PubMed  CAS  Google Scholar 

  110. Refetoff S. Resistance to thyroid hormone. Curr Ther Endocrinol Metab. 1997;6:132–4.

    PubMed  CAS  Google Scholar 

  111. Refetoff S. Resistance to thyroid hormone with and without receptor gene mutations. Ann Endocrinol (Paris). 2003;64(1):23–5.

    CAS  Google Scholar 

  112. Refetoff S. Resistance to thyrotropin. J Endocrinol Invest. 2003;26(8):770–9.

    PubMed  CAS  Google Scholar 

  113. Ishay A, Dumitrescu A, Luboshitzky R, Rakover Y, Refetoff S. A new case of resistance to thyroid hormone caused by a de novo P453T mutation in the thyroid hormone receptor gene in an Israeli child. Thyroid. 2003;13(4):409–12.

    Article  PubMed  CAS  Google Scholar 

  114. Gershengorn MC, Osman R. Molecular and cellular biology of thyrotropin-releasing hormone receptors. Physiol Rev. 1996;76(1):175–91.

    PubMed  CAS  Google Scholar 

  115. Persani L. Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity. Thyroid. 1998;8:941–6.

    PubMed  CAS  Google Scholar 

  116. Yamada M, Satoh T, Mori M. Mice lacking the thyrotropin-releasing hormone gene: what do they tell us? Thyroid. 2003;13(12):1111–21.

    Article  PubMed  CAS  Google Scholar 

  117. Heur H, Schafer MK, Bauer K. Thyrotropin-releasing hormone (TRH), a signal peptide of the central nervous system. Acta Med Austriaca. 1999;26:119–22.

    Google Scholar 

  118. Safran M, Wu CF, Emerson CH. Thyrotropin-releasing hormone metabolism in visceral organ homogenates of the rat. Endocrinology. 1982;110(6):2101–6.

    PubMed  CAS  Google Scholar 

  119. Zervas IM, Papakostas YG, Theodoropoulou MA, Dimitrakopoulos C, Vaidakis N, Daras M. Thyrotropinreleasing hormone administration does not affect seizure threshold during electroconvulsive therapy. J Ect. 2003;19(3):136–8.

    PubMed  Google Scholar 

  120. Choi YH, Hartzell D, Azain MJ, Baile CA. TRH decreases food intake and increases water intake and body temperature in rats. Physiol Behav. 2002; 77(1):1–4.

    Article  PubMed  CAS  Google Scholar 

  121. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev. 2002;82(2):473–502.

    PubMed  CAS  Google Scholar 

  122. Joshi L, Murata, Y, Wondisford FE, Szkudlinski MW, Desai R, Weintraub BD. Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance. Endocrinology. 1995;136(9):3839–48.

    Article  PubMed  CAS  Google Scholar 

  123. Szkudlinski MW, Thotakura NR, Bucci I, et al. Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity. Endocrinology. 1993;133(4):1490–503.

    Article  PubMed  CAS  Google Scholar 

  124. Pazos-Moura CC, Ortiga-Carvalho TM, Gaspar de Moura E. The autocrine/paracrine regulation of thyrotropin secretion. Thyroid. 2003;13(2):167–75.

    Article  PubMed  CAS  Google Scholar 

  125. Fuhrer D, Wonerow P, Willgerodt H, Paschke R. Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism. J Clin Endocrinol Metab. 1997;82(12):4234–8.

    Article  PubMed  CAS  Google Scholar 

  126. Fuhrer D, Holzapfel HP, Wonerow P, Paschke R. Constitutively activating mutations of the thyrotropin receptor and thyroid disease. Eur J Med Res. 1996; 1(10):460–4.

    PubMed  CAS  Google Scholar 

  127. Trulzsch B, Krohn K, Wonerow P, et al. Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis. J Mol Med. 2001;78(12): 684–91.

    Article  PubMed  CAS  Google Scholar 

  128. Krohn K, Fuhrer D, Holzapfel HP, Paschke R. Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations. J Clin Endocrinol Metab. 1998;83(1):130–4.

    Article  PubMed  CAS  Google Scholar 

  129. Wallaschofski H, Muller D, Georgi P, Paschke R. Induction of TSH-receptor antibodies in patients with toxic multinodular goitre by radioiodine treatment. Horm Metab Res. 2002;34(1):36–9.

    Article  PubMed  CAS  Google Scholar 

  130. Fuhrer D, Lachmund P, Nebel IT, Paschke R. The thyrotropin receptor mutation database: update 2003. Thyroid. 2003;13(12):1123–6.

    Article  PubMed  CAS  Google Scholar 

  131. University of Leipzig. TSH Receptor Database. Online Posting. 2001–2003. www.uni-leipzig.de/innere/tshr.

    Google Scholar 

  132. Myhill J. Thyroidal adjustment to the iodine environment. J Endocrinol. 1965;33(3):429–36.

    Article  PubMed  CAS  Google Scholar 

  133. Ingbar SH. Autoregulation of the thyroid. Response to iodide excess and depletion. Mayo Clin Proc. 1972; 47(11):814–23.

    PubMed  CAS  Google Scholar 

  134. Filetti S, Rapoport B. Autoregulation by iodine of thyroid protein synthesis: influence of iodine on amino acid transport in cultured thyroid cells. Endocrinology. 1984;114(4):1379–85.

    PubMed  CAS  Google Scholar 

  135. Pisarev MA. Thyroid autoregulation. J Endocrinol Invest. 1985;8(5):475–84.

    PubMed  CAS  Google Scholar 

  136. Nagataki S, Yokoyama N. Autoregulation: effects of iodine. Acta Med Austriaca. 1990;17Suppl 1:4–8.

    PubMed  Google Scholar 

  137. Penel C, Rognoni JB, Bastiani P. Thyroid autoregulation: impact on thyroid structure and function in rats. Am J Physiol. 1987;253(2 Pt 1):E165–72.

    PubMed  CAS  Google Scholar 

  138. Berkowitz M, Daughtridge D, Sherwin JR. Autoregulation of thyroid iodide transport: possible mediation by modification in sodium cotransport. Am J Physiol. 1981;240(1):E37–42.

    PubMed  CAS  Google Scholar 

  139. Santisteban P, Lamas L. The effect of varying iodine content on the proteolytic activity of rat thyroid lysosomes. Acta Endocrinol (Copenh). 1981;98(4):556–63.

    CAS  Google Scholar 

  140. Viera AJ. Thyroid function testing in outpatients: are both sensitive thyrotropin (sTSH) and free thyroxine (FT4) necessary? Fam Med. 2003;35(6):408–10.

    PubMed  Google Scholar 

  141. Christ-Crain M, Meier C, Roth CB, Huber P, Staub JJ, Muller B. Basal TSH levels compared with TRHstimulated TSH levels to diagnose different degrees of TSH suppression: diagnostic and therapeutic impact of assay performance. Eur J Clin Invest. 2002; 32(12):931–7.

    Article  PubMed  CAS  Google Scholar 

  142. Gorges R, Saller B, Eising EG, Quadbeck B, Mann K, Bockisch A. Surveillance of TSH-suppressive levo-thyroxine treatment in thyroid cancer patients: TRH testing versus basal TSH determination by a third generation assay. Exp Clin Endocrinol Diabetes. 2002;110(7):355–60.

    Article  PubMed  CAS  Google Scholar 

  143. Allahabadia A, Weetman AP. Dynamic thyroid stimulating hormone tests: do they still have a role? J Endocrinol Invest. 2003;26(7 Suppl):31–8.

    PubMed  CAS  Google Scholar 

  144. Mishriki YY. A combination of T3, and T4 for hypothyroidism? Postgrad Med. 2004;115(4):17–8.

    Article  PubMed  Google Scholar 

  145. Clyde PW, Harari AE, Getka EJ, Shakir KM. Combined levo-thyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. Jama. 2003;290(22):2952–8.

    Article  PubMed  CAS  Google Scholar 

  146. Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3′-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab. 2003; 88(10):4551–5.

    Article  PubMed  CAS  Google Scholar 

  147. Walsh JP, Shiels L, Lim EM, et al. Combined thyroxine/liothyronine treatment does not improve wellbeing, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J Clin Endocrinol Metab. 2003;88(10):4543–50.

    Article  PubMed  CAS  Google Scholar 

  148. Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf). 2003;58(2):138–40.

    Article  CAS  Google Scholar 

  149. Mitchell DR, Parvin CA, Gronowski AM. Rules-based detection of discrepancies between TSH and free T4 results. Clin Chim Acta. 2003;332(1–2):89–94.

    Article  PubMed  CAS  Google Scholar 

  150. Morris LF, Waxman AD, Braunstein GD. Interlaboratory comparison of thyroglobulin measurements for patients with recurrent or metastatic differentiated thyroid cancer. Clin Chem. 2002;48(8):1371–2.

    PubMed  CAS  Google Scholar 

  151. Tozzoli R, Bizzaro N, Tonutti E, et al. Immunoassay of anti-thyroid autoantibodies: high analytical variability in second generation methods. Clin Chem L ab Med. 2002;40(6):568–73.

    Article  CAS  Google Scholar 

  152. Rendl J, Bier D, Reiners C. Methods for measuring iodine in urine and serum. Exp Clin Endocrinol Diabetes. 1998;106Suppl 4:S34–41.

    Article  PubMed  CAS  Google Scholar 

  153. Demers L, Spencer CA. Urinary iodine measurement. NACB: Laboratory support for the diagnosis and monitoring of thyroid disease. 2002:74–8.

    Google Scholar 

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(2006). Thyroid Anatomy and Physiology. In: Management of Thyroid Cancer and Related Nodular Disease. Springer, London . https://doi.org/10.1007/1-84628-006-0_2

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