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Cellular Mechanisms of Endocrine Disruption

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References

  1. Colborn T, Dumanoski D, Myers JP (1996) Our Stolen Future: Are We Threatening Our Fertility, Intelligence and Survival? New York: Penguin Group.

    Google Scholar 

  2. Stone R. (1994) Environmental estrogens stir debate. Science 265, 308–310.

    Article  PubMed  CAS  Google Scholar 

  3. Sharpe RM, Skakkebaek NE. (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392–1395.

    Article  PubMed  CAS  Google Scholar 

  4. Fisher JS. (2004) Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 127, 305–315.

    Article  PubMed  CAS  Google Scholar 

  5. Snedeker SM. (2001) Pesticides and breast cancer risk: a review of DDT, DDE, and Dieldrin. Environ Health Perspect 9( Suppl 1), 35–47.

    Article  Google Scholar 

  6. Rubin CH, Lanier A, Kieszak S, Brock JW, Koller KR, Strosnider H, Neeedham L, Zahm S, Harpster A. (2006) Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals. Int J Circumpolar Health 65, 18–27.

    PubMed  Google Scholar 

  7. Colborn T, vom Saal FS, Soto AM. (1993) Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101, 378–384.

    Article  PubMed  CAS  Google Scholar 

  8. Fein GG, Jacobson JL, Jacobson JW, Schwartz PM, Fowler JK. (1984) Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr 105, 315–320.

    Article  PubMed  CAS  Google Scholar 

  9. Jacobson JL, Jacobson SW, Humphrey HEB. (1990) Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr 116, 38–45.

    Article  PubMed  CAS  Google Scholar 

  10. Schmutzler C, Bacinski A, Ambrugger P, Huhne K, Grüters A, Köhrle J. (2006) Thyroid hormone biosynthesis is a sensitive target for the action of endocrine disrupting chemicals (EDC). Exp Clin Endocrinol Diabetes 114. http://www.thieme-connect.com/ejournals/abstract/eced/doi/ 10.1055/s-2006-932882.

    Google Scholar 

  11. Anway MD, Skinner MK. (2006) Epigenetic transgenerational actions of endocrine disruptors. Endocrinology 147, S43–S49.

    Article  PubMed  CAS  Google Scholar 

  12. Crews D, McLachlan JA. (2006) Epigenetics, evolution, endocrine disruption, health, and disease. Endocrinology 147, S4–S10.

    Article  PubMed  CAS  Google Scholar 

  13. Newbold RR, Padilla-Banks E, Jefferson WN. (2006) Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 147, S11–S17.

    Article  PubMed  CAS  Google Scholar 

  14. Anway MD, Cupp AS, Uzumcu M, Skinner MK. (2005) Epigenetic transgenerational actions of endocrine disrupters and male fertility. Science 308, 1466–1469.

    Article  PubMed  CAS  Google Scholar 

  15. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM. (1995) Persistent DDT metabolite p,p’-DDE is a potent androgen receptor antagonist. Nature 375, 581–585.

    Article  PubMed  CAS  Google Scholar 

  16. Foster PM, Mylchreest E, Gaido KW, Sar M. (2001) Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update 7, 231–235.

    Article  PubMed  CAS  Google Scholar 

  17. Whitehead SA, Rice S. (2006) Endocrine-disrupting chemicals as modulators of sex steroid synthesis. Best Pract Res Clin Endocrinol Metab 20, 45–61.

    Article  PubMed  CAS  Google Scholar 

  18. Chen S. (2002) Modulation of aromatase activity and expression by environmental chemicals. Front Biosci 7, 1712–1719.

    Google Scholar 

  19. Woodhouse AJ, Cooke GM. (2004) Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221. Toxicol Lett 30, 91–100.

    Article  CAS  Google Scholar 

  20. Grün F, Blumberg B. (2006) Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147, S50–S55.

    Article  PubMed  CAS  Google Scholar 

  21. Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. (2005) Organotin compounds promote adipocyte differentiation as agonists of theperoxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol Pharmacol 67, 766–774.

    Article  PubMed  CAS  Google Scholar 

  22. Giguere V, Tremblay A, Tremblay GB. (1998) Estrogen receptor beta: re-evaluation of estrogen and antiestrogen signaling. Steroids 63, 335–339.

    Article  PubMed  CAS  Google Scholar 

  23. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-Å. (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93, 5925–5930.

    Article  PubMed  CAS  Google Scholar 

  24. Mosselman S, Polman J, Dijkema R. (1996) ER β : identification and characterization of a novel human estrogen receptor. FEBS Lett 392, 49–53.

    Article  PubMed  CAS  Google Scholar 

  25. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguére V. (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor. Mol Endocrinol 11, 353–365.

    Article  PubMed  CAS  Google Scholar 

  26. Byers M, Kuiper GGJM, Gustafsson J-Å, Park-Sarge O-K. (1997) Estrogen receptor- β mRNA expression in rat ovary: down-regulation by gonadotropins. Mol Endocrinol 11, 172–182.

    Article  PubMed  CAS  Google Scholar 

  27. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson J-Å. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β . Endocrinology 138, 863–870.

    Article  PubMed  Google Scholar 

  28. Beato M. (1991) Transcriptional control by nuclear receptors. FASEB J 5, 2044–2051.

    PubMed  CAS  Google Scholar 

  29. Levin ER. (2005) Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 19, 1951–1959.

    Article  PubMed  CAS  Google Scholar 

  30. Watson CS, Campbell CH, Gametchu B. (1999) Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogens. Exp Physiol 84, 1013–1022.

    Article  PubMed  CAS  Google Scholar 

  31. Pedram A, Razandi M, Levin ER. (2006) Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol 20, 1996–2009 [Epub ahead of print, April 27].

    Article  PubMed  CAS  Google Scholar 

  32. Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ. (1997) Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 45, 607–617.

    Article  PubMed  CAS  Google Scholar 

  33. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. (2005) A. transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307, 1625–1630.

    Article  PubMed  CAS  Google Scholar 

  34. Filardo EJ, Thomas P. (2005) GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. Trends Endocrinol Metab 16, 362–367.

    Article  PubMed  CAS  Google Scholar 

  35. Psarra AM, Solakidi S, Sekeris CE. (2006) The mitochondrion as a primary site of action of steroid and thyroid hormones: presence and action of steroid and thyroid hormone receptors in mitochondria of animal cells. Mol Cell Endocrinol 246, 21–33.

    Article  PubMed  CAS  Google Scholar 

  36. Chen JQ, Yager JD, Russo J. (2005) Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications. Biochim Biophys Acta 1746, 1–17.

    Article  PubMed  CAS  Google Scholar 

  37. Yager JD, Davidson NE. (2006) Estrogen carcinogenesis in breast cancer. N Engl J Med 354, 270–282.

    Article  PubMed  CAS  Google Scholar 

  38. Spink DC, Johnson JA, Connor SP, Aldous KM, Gierthy JF. (1984) Stimulation of 17 β -estradiol metabolism in MCF-7 cells by bromochloro- and chloromethyl-substituted dibenzo- p -dioxins and dibenzofurans: correlations with antiestrogenic activity. J Toxicol Environ Health 41, 451–466.

    Article  Google Scholar 

  39. Spink DC, Eugster H-P, Lincoln II, DW, Schuetz JD, Schuetz EG, Johnson JA, Kaminsky LS, Gierthy JF. (1992) 17 β -estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,-tetrachlorodibenzo- p -dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 293, 342–348.

    Article  PubMed  CAS  Google Scholar 

  40. Beato M. (1989) Gene regulation by steroid hormones. Cell 56, 335–344.

    Article  PubMed  CAS  Google Scholar 

  41. Wilson JD, Foster DW. (eds) (1985) Textbook of Endocrinology. W. B. Saunders Co., Philadelphia, PA.

    Google Scholar 

  42. Adler S, Waterman ML, He X, Rosenfeld MG. (1988) Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 52, 685–695.

    Article  PubMed  CAS  Google Scholar 

  43. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR. (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249, 1266–1272.

    Article  PubMed  CAS  Google Scholar 

  44. Tzukerman M, Zhang X-K, Pfahl M. (1991) Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis. Mol Endocrinol 5, 1983–1992.

    PubMed  CAS  Google Scholar 

  45. Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P. (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62, 1189–1204.

    Article  PubMed  CAS  Google Scholar 

  46. Lucibello FC, Slater EP, Jooss KU, Beato M, Müller R. (1990) Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO J 9, 2827–2834.

    PubMed  CAS  Google Scholar 

  47. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M. (1990) Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62, 1205–1215.

    Article  PubMed  CAS  Google Scholar 

  48. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolando J, Yang N, Verma IM, Evans RM. (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62, 1217–1226.

    Article  PubMed  Google Scholar 

  49. Webb P, Lopez GN, Uht RM, Kushner PJ. (1995) Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9, 443–456.

    Article  PubMed  CAS  Google Scholar 

  50. Weinberg RA. (1991) Tumor suppressor genes. Science 254, 1138–1146.

    Article  PubMed  CAS  Google Scholar 

  51. Foster JS, Wimalasena J. (1996) Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells. Mol Endocrinol 10, 488–498.

    Article  PubMed  CAS  Google Scholar 

  52. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J. (1986) Sequence and expression of human estrogen receptor complementary DNA. Science 231, 1150–1154.

    Article  PubMed  CAS  Google Scholar 

  53. Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P. (1989) The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59, 477–487.

    Article  PubMed  CAS  Google Scholar 

  54. Waterman ML, Adler S, Nelson C, Greene GL, Evans RM, Rosenfeld MG. (1988) A single domain of the estrogen receptor confers DNA binding and transcriptional activation of the rat prolactin gene. Mol Endocrinol 2, 14–21.

    PubMed  CAS  Google Scholar 

  55. Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP. (1994) Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 8, 21–30.

    Article  PubMed  CAS  Google Scholar 

  56. Berry M, Metzger D, Chambon P. (1990) Role of the two activating domains of the oestrogen receptor in the cell-type and promoter context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9, 2811–2818.

    PubMed  CAS  Google Scholar 

  57. Ramkumar T, Adler S. (1995) Differential positive and negative transcriptional regulation by tamoxifen. Endocrinology 136, 536–542.

    Article  PubMed  CAS  Google Scholar 

  58. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson J-Å, Kushner PJ, Scanlan TS. (1997) Differential ligand activation of estrogen receptors ER α and ER β at AP1 sites. Science 277, 1508–1510.

    Article  PubMed  CAS  Google Scholar 

  59. Cotton P. (1994) Environmental estrogenic agents area of concern. JAMA 271, 414–416.

    Article  PubMed  CAS  Google Scholar 

  60. Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson J-Å. (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor. Endocrinology 139, 4252–4263.

    Article  PubMed  CAS  Google Scholar 

  61. Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson J, Nilsson S. (1998) Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol 54, 105–112.

    PubMed  CAS  Google Scholar 

  62. De Angelis M, Stossi F, Carlson KA, Katzenellenbogen BS, Katzenellenbogen JA. (2005) Indazole estrogens: highly selective ligands for the estrogen receptor beta. J Med Chem 48, 1132–1144.

    Article  PubMed  CAS  Google Scholar 

  63. Zaitseva M, Yue DS, Katzenellenbogen JA, Rogers PA, Gargett CE. (2004) Estrogen receptor-alpha agonists promote angiogenesis in human myometrial microvascular endothelial cells. J Soc Gynecol Investig 11, 529–535.

    Article  PubMed  CAS  Google Scholar 

  64. Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA. (2004) Pyrazolo[1, 5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. J Med Chem 47, 5872–5893. Erratum in: J Med Chem 48, 2724.

    Google Scholar 

  65. Harrington WR, Sheng S, Barnett DH, Petz LN, Katzenellenbogen JA, Katzenellenbogen BS. (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol 206, 13–22.

    Article  PubMed  CAS  Google Scholar 

  66. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem 43, 4934–4947.

    Article  PubMed  CAS  Google Scholar 

  67. Pak TR, Chung WC, Lund TD, Hinds LR, Clay CM, Handa RJ. (2005) The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells. Endocrinology 146, 147–155. Epub October 7, 2004.

    Article  PubMed  CAS  Google Scholar 

  68. Imamov O, Lopatkin NA, Gustafsson JA. (2004) Estrogen receptor beta in prostate cancer. N Engl J Med 351, 2773–2774.

    Article  PubMed  Google Scholar 

  69. Alves SE, Lopez V, McEwen BS, Weiland ng. (1998) Differential colocalization of estrogen receptor β (ER β ) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical study. Proc Natl Acad Sci USA 95, 3281–3286.

    Article  PubMed  CAS  Google Scholar 

  70. Shughrue PJ, Lane MV, Merchenthaler I. (1997) Comparative distribution of estrogen receptor- α and β -mRNA in the rat central nervous system. J Comp Neurol 388, 507–525.

    Article  PubMed  CAS  Google Scholar 

  71. Dotzlaw H, Leygue E, Watson PH, Murphy LC. (1997) Expression of estrogen receptor-beta in human breast tumors. J Clin Endocrinol Metab 82, 2371–2374.

    Article  PubMed  CAS  Google Scholar 

  72. Ferguson AT, Lapidus RG, Davidson NE. (1998) The regulation of estrogen receptor expression and function in human breast cancer. Cancer Treat Res 94, 255–278.

    PubMed  CAS  Google Scholar 

  73. Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lupu R. (1998) Expression of estrogen receptor beta messenger RNA variant in breast cancer. Cancer Res 58, 210–214.

    PubMed  CAS  Google Scholar 

  74. Halachmi S, Marden E, Martin G, MacKay H, Abbonanza C, Brown M. (1994) Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science 264, 1455–1458.

    Article  PubMed  CAS  Google Scholar 

  75. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403–414.

    Article  PubMed  CAS  Google Scholar 

  76. Warnmark A, Almlof T, Leers J, Gustafsson JA, Treuter E. (2001) Differential recruitment: of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta. J Biol Chem 276, 23397–23404.

    Article  PubMed  CAS  Google Scholar 

  77. Evans RM. (1988) The steroid and thyroid hormone receptor superfamily. Science 240, 889–895.

    Article  PubMed  CAS  Google Scholar 

  78. Lam PH-Y. (1984) Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 118, 27–32.

    Article  PubMed  CAS  Google Scholar 

  79. O’Brian CA, Liskamp RM, Solomon DH, Weinstein IB. (1985) Inhibition of protein kinase C by tamoxifen. Cancer Res 45, 2462–2465.

    PubMed  CAS  Google Scholar 

  80. Issandou M, Faucher C, Bayard F, Darbon JM. (1990) Opposite effects of tamoxifen on in vitro protein kinase c activity and endogenous protein phosphorylation in intact MCF-7 cells. Cancer Res 50, 5845–5850.

    PubMed  CAS  Google Scholar 

  81. Jordan VC, Collins MM, Rowsby L, Prestwich G (1977) A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity. J Endocrinol 75, 305–316.

    PubMed  CAS  Google Scholar 

  82. Johanson G. (2000) Toxicity review of ethylene glycol monomethyl ether and its acetate ester. Crit Rev Toxicol 207, 149–163.

    Google Scholar 

  83. Cummings AM. (1997) Methoxychlor as a model for environmental estrogens. Crit Rev Toxicol 27, 367–379.

    Article  PubMed  CAS  Google Scholar 

  84. Brotons JA, Olea-Serrano MF, Villalobos M, Pedraza V, Olea N. (1995) Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 103, 608–612.

    Article  PubMed  CAS  Google Scholar 

  85. Krishnan AV, Starhis P, Permuth SF, Tokes L, Feldman D. (1993) Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132, 2279–2286.

    Article  PubMed  CAS  Google Scholar 

  86. Jobling S, Sumpter JP. (1993) Detergent components in sewage effluent are weakly estrogenic to fish - an in-vitro study using rainbow-trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 27, 361–372.

    Article  CAS  Google Scholar 

  87. Mueller GC, Kim U-H. (1978) Displacement of estradiol from estrogen receptors by simple alkyl phenols. Endocrinology 102, 1429–1435.

    Article  PubMed  CAS  Google Scholar 

  88. Soto AM, Justicia H, Wray JW, Sonnenschein C. (1991) p-Nonyl-phenol: an estrogenic xenobiotic released from ‘‘modified’’ polystyrene. Environ Health Perspect 92, 167–173.

    Article  PubMed  CAS  Google Scholar 

  89. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175–182.

    Article  PubMed  CAS  Google Scholar 

  90. ENDS. (1995) Packaging industry failing to act over phthalates in food. ENDS Rep 245, 7–8.

    Google Scholar 

  91. JEH 1995. Environmental oestrogens: Consequences to human health and wildlife. Institute for Environment and Health, University of Leicester, Leicester, UK.

    Google Scholar 

  92. Beekman JM, Allan GF, Tsai SY, Tsai M-J, O’Malley BW. (1993) Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol Endocrinol 7, 1266–1274.

    Article  PubMed  CAS  Google Scholar 

  93. Metzger D, Berry M, Ali S, Chambon P. (1995) Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. Mol Endocrinol 9, 579–591.

    Article  PubMed  CAS  Google Scholar 

  94. Brown M, Sharp PA. (1990) Human estrogen receptor forms multiple protein-DNA complexes. J Biol Chem 265, 11238–11243.

    PubMed  CAS  Google Scholar 

  95. Meyers CY, Lutfi HG, Adler S. (1997) Transcriptional regulation of estrogen-responsive genes by non-steroidal estrogens: doisynolic and allenolic acids. J Steroid Biochem Mol Biol 62, 477–489.

    Article  PubMed  CAS  Google Scholar 

  96. Meyers CY, Hou Y, Winters TA, Banz WJ, Adler S. (2002) Activities of a non-classical estrogen, Z-bis-dehydrodoisynolic acid, with ER α and ER β . J Steroid Biochem Mol Biol 82, 33–44.

    Article  PubMed  CAS  Google Scholar 

  97. Dibbs KI, Sadovsky Y, Li X-J, Koide SS, Adler S, Fuchs A-R. (1995) Estrogenic activity of RU486 (Mifepristone) in rat uterus and cultured uterine myocytes. Am J Obstet Gynecol 173, 134–140.

    Article  PubMed  CAS  Google Scholar 

  98. Adler M, Hou Y, Sandrock P, Meyers CY, Winters TA, Banz WJ, Adler S. (2006) Derivatives of Z-bisdehydrodoisynolic acid provide a new description of the binding-activity paradox and selective estrogen receptor modulator activity. Endocrinology 147( 8), 3952–3960. Epub May 18, as doi:10.1210/en.2006-0316.

    Article  PubMed  CAS  Google Scholar 

  99. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. (1986) Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA 83, 2496–2500.

    Article  PubMed  CAS  Google Scholar 

  100. Segaloff A. (1949) The metabolism of estrogens with particular emphasis on clinical aspects of physiology, function of ovarian hormones. In Recent Progress in Human Research, Vol. IV (edited by G. Pincus). Academic Press, New York, pp. 85–111.

    Google Scholar 

  101. Tora L, Mullick A, Metzger D, Ponglikitmongkol M, Park I, Chambon P. (1989) The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J 8, 1981–1986.

    PubMed  CAS  Google Scholar 

  102. Zhang Q-X, Borg A, Wolff DM, Oesterreich S, Fuqua SAW. (1997) An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Res 57, 1244–1249.

    PubMed  CAS  Google Scholar 

  103. Krishnan V, Safe S. (1993) Polychlorinated biphenyls (PCBs), dibenzo- p -dioxins PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol Appl Pharmacol 120, 55–61.

    Article  PubMed  CAS  Google Scholar 

  104. Jordan CV, Mittal S, Gosden B, Koch R, Lieberman ME. (1985) Structure-activity relationships of estrogens. Environ Health Perspect 61, 97–110.

    Article  PubMed  CAS  Google Scholar 

  105. Jansen HT, Cooke PS, Porcelli J, Liu T-C, Hansen LG. (1993) Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies. Reprod Toxicol 7, 237–248.

    Article  PubMed  CAS  Google Scholar 

  106. Liang P, Pardee AB. (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967–971.

    Article  PubMed  CAS  Google Scholar 

  107. Liang P, Averboukh L, Pardee AB. (1993) Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res 21, 3269–3275.

    Article  PubMed  CAS  Google Scholar 

  108. Jamil A, Croxtall JD, White JO. (1991) The effect of anti-estrogens on cell growth and progesterone receptor concentration in human endometrial cancer cells (Ishikawa). J Mol Endocrinol 6, 215–221.

    Article  PubMed  CAS  Google Scholar 

  109. Lippman ME, Dickson RB. (1989) Mechanisms of growth control in normal and malignant breast epithelium. Recent Prog Horm Res 45, 383–440.

    PubMed  CAS  Google Scholar 

  110. Rose DP, Boyar AP, Wynder EL. (1986) International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 58, 2363–2371.

    Article  PubMed  CAS  Google Scholar 

  111. Lee HP, Gourley L, Duffy SW, Estéve J, Lee J, Day NE. (1991) Dietary effects on breast-cancer risk in Singapore. Lancet 337, 1197–1200.

    Article  PubMed  CAS  Google Scholar 

  112. Goodman MJ. (1991) Breast cancer on multi-ethnic populations: the Hawaii perspective. Breast Cancer Res Treat 18( Suppl 1), S5–S9.

    Article  PubMed  Google Scholar 

  113. Key TJ, Thorogood M, Appleby PN, Burr ML. (1996) Dietary habits and mortality in 11,000 vegetarians and health conscious people: results of a 17 year follow up. BMJ 313, 775–779.

    PubMed  CAS  Google Scholar 

  114. Herman C, Adlercreutz T, Goldin BR, Gorbach SL, Höckerstedt KAV, Watanabe S, Hämäläinen EK, Markkanen MH, Mäkelä TH, Wähälä KT, Hase TA, Fotsis T. (1995) Soybean phytoestrogen intake and cancer risk. J Nutr 125, 757S–770S.

    CAS  Google Scholar 

  115. Whitten PL, Lewis C, Russell E, Naftolin F. (1995) Potential adverse effects of phytoestrogens. J Nutr 125, 771S–776S.

    PubMed  CAS  Google Scholar 

  116. Knight DC, Eden JA. (1996) A review of clinical effects of phytoestrogens. Obstet Gynecol 87, 897–904.

    PubMed  CAS  Google Scholar 

  117. Kurzer MS, Xu X. (1997) Dietary phytoestrogens. Annu Rev Nutr 17, 353–381.

    Article  PubMed  CAS  Google Scholar 

  118. King ML, Adler SR, Murphy LL. Extraction-dependent effects of American Ginseng (Panax quinquefolium) on human breast cancer cell proliferation and estrogen receptor activation. Integr Cancer Ther. Sep; 5( 3): 236–2430.

    Google Scholar 

  119. Xu L, Glass CK, Rosenfeld MG. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev 9, 140–147.

    Article  PubMed  CAS  Google Scholar 

  120. Shibata H, Spencer TE, Onate SA, Jenster G, Tsai SY, Tsai MJ, O’Malley BW. (1997) Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 52, 141–164.

    PubMed  CAS  Google Scholar 

  121. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677–684.

    Article  PubMed  CAS  Google Scholar 

  122. Oñate SA, Tsai SY, Tsai M-J, O’Malley BW. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354–1357.

    Article  PubMed  Google Scholar 

  123. Blanco JCG, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y, Ozato K. (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev 12, 1638–1651.

    PubMed  CAS  Google Scholar 

  124. Chen JD, Li H. (1998) Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors. Crit Rev Eukaryot Gene Expr 8, 169–190.

    PubMed  CAS  Google Scholar 

  125. Chen JD, Evans RM. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454–457.

    Article  PubMed  CAS  Google Scholar 

  126. Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK, Rosenfeld MG. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404.

    Article  PubMed  Google Scholar 

  127. Lavinsky RM, Jepsen K, Heinzel T, Torchia J, Mullen TM, Schiff R, Delrio AL, Ricote M, Ngo S, Gemsch J, Hilsenbeck SG, Osborne CK, Glass CK, Rosenfeld MG, Rose DW. (1998) Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc Natl Acad Sci USA 95, 2920–2925.

    Article  PubMed  CAS  Google Scholar 

  128. Nishikawa J, Saito K, Goto J, Dakeyama F, Matsuo M, Nishihara T. (1999) New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator. Toxicol Appl Pharmacol 154, 76–83.

    Article  PubMed  CAS  Google Scholar 

  129. Smith CL, Nawaz Z, O’Malley BW. (1997) Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol 11, 657–666.

    Article  PubMed  CAS  Google Scholar 

  130. Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L, Horwitz KB. (1997) The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Mol Endocrinol 11, 693–705.

    Article  PubMed  CAS  Google Scholar 

  131. Zhang X, Jeyakumar M, Petukhov S, Bagchi MK. (1998) A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor. Mol Endocrinol 12, 513–524.

    Article  PubMed  CAS  Google Scholar 

  132. Takimoto GS, Graham JD, Jackson TA, Tung L, Powell RL, Horwitz LD, Horwitz KB. (1999) Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. J Steroid Biochem Mol Biol 69, 45–50.

    Article  PubMed  CAS  Google Scholar 

  133. Brzozowski AM, Pike ACW, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson J-A, Carlquist M. (1997) Molecular basis of agonism and antagonism in the estrogen receptor. Nature 389, 753–758.

    Article  PubMed  CAS  Google Scholar 

  134. Berns EM, van Staveren IL, Klijn JG, Foekens JA. (1998) Predictive value of SRC-1 for tamoxifen response of recurrent breast cancer. Breast Cancer Res Treat 48, 87–92.

    Article  PubMed  CAS  Google Scholar 

  135. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS. (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965–968.

    Article  PubMed  CAS  Google Scholar 

  136. Eng FCS, Barsalou A, Akutsu N, Mercier I, Zechel C, Mader S, White JH. (1998) Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. J Biol Chem 273, 28371–28377.

    Article  PubMed  CAS  Google Scholar 

  137. Misiti S, Schomburg L, Yen PM, Chin WW. (1998) Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology 139, 2493–2500.

    Article  PubMed  CAS  Google Scholar 

  138. Nguyen TA, Hoivik D, Lee JE, Safe S. (1999) Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch Biochem Biophys 15, 250–257.

    Article  Google Scholar 

  139. Hornick JR, Zhang Z, Romans SR, Adler M, Adler S. (2004) Regulation of the SMRT Promoter by Estrogens. Endocrine Society - 86th Annual Meeting, Abstract P1-187.

    Google Scholar 

  140. Adler RA, Adler SR. (2002) Regulation of the Expression of Nuclear Receptor Coregulators SRC-1 and SMRT in Response to Estradiol and the Phytoestrogen Genistein. Endocrine Society - 84th Annual Meeting, Abstract P2-467.

    Google Scholar 

  141. [No authors listed]. (1999) Food labeling: health claims; soy protein and coronary heart disease. Food and drug administration, HHS. Final rule. Fed Regist 64( 206), 57700–57733.

    Google Scholar 

  142. Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG, Huang YZ. (2001) Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review). Int J Mol Med 8, 3–17.

    PubMed  CAS  Google Scholar 

  143. Peeters PH, Keinan-Boker L, van der Schouw YT, Grobbee DE. (2003) Phytoestrogens and breast cancer risk. Review of the epidemiological evidence. Breast Cancer Res Treat 77, 171–183.

    Article  PubMed  CAS  Google Scholar 

  144. Mishra SI, Dickerson V, Najm W. (2003) Phytoestrogens and breast cancer prevention: What is the Evidence? Am J Obstet Gynecol 188( 5 Suppl), S66–S70.

    Article  PubMed  CAS  Google Scholar 

  145. Ganry O. (2005) Phytoestrogens and prostate cancer risk. Prev Med 41, 1–6.

    Article  PubMed  CAS  Google Scholar 

  146. Katic M, Kahn CR. (2005) The role of insulin and IGF-1 signaling in longevity. Cell Mol Life Sci 62, 320–43.

    Article  PubMed  CAS  Google Scholar 

  147. Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A. (2005) Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 146, 851–860.

    Article  PubMed  CAS  Google Scholar 

  148. Hall SS. (2003) In Vino Vitalis? compounds activate life-extending genes. Science 301, 1165.

    Article  PubMed  CAS  Google Scholar 

  149. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191–196.

    Article  PubMed  CAS  Google Scholar 

  150. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.

    Article  PubMed  CAS  Google Scholar 

  151. Imai S, Armstrong CM, Kaeberlein M, Guarente L. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800.

    Article  PubMed  CAS  Google Scholar 

  152. Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. (2004) Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci USA 101, 7199–7204.

    Article  PubMed  CAS  Google Scholar 

  153. Yoshida M, Kijima M, Akita M, Beppu T. (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265, 17174–17179.

    PubMed  CAS  Google Scholar 

  154. Marlett JA, McBurney MI, Slavin JL, the American Dietetic Association. (2002) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 102, 993–1000.

    Article  PubMed  Google Scholar 

  155. Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132, 1012–1017.

    PubMed  CAS  Google Scholar 

  156. Davie JR. (2003) Inhibition of histone deacetylase activity by butyrate. J Nutr 133( Suppl), 2485S–93S.

    PubMed  CAS  Google Scholar 

  157. Chen YX, Fang JY, Zhu HY, Lu R, Cheng ZH, Qiu DK. (2004) Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. World J Gastroenterol 10, 2643–2646.

    PubMed  CAS  Google Scholar 

  158. Villar-Garea A, Esteller M. (2004) Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer 112, 171–178.

    Article  PubMed  CAS  Google Scholar 

  159. Winters TA, Banz WJ, Mallon MA, Adler S. (1999) Estrogenic gene activation and estrogenic gene repression by phytoestrogens define two functional classes. World Soybean Research Conference IV - Global Soy Forum 99, Chicago, IL. August 4–7.

    Google Scholar 

  160. Gehm B, McAndrews J, Chien P-Y, Jameson L. (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA 94, 14138–14143.

    Article  PubMed  CAS  Google Scholar 

  161. Li W, Adler S. (2005) Resveratrol as an estrogenic superinducer: participation as ligand, signal multiplier and via the MAPK pathway. The Endocrine Society Forum on Endocrine Disrupting Chemicals, San Diego, CA. June 3.

    Google Scholar 

  162. Li W, Romans SR, Adler S. (2004) Superinduction of gene expression by resveratrol can occur independent of estrogen receptors. Endocrine Society - 86th Annual Meeting. Abstract P1-102.

    Google Scholar 

  163. Trammel AC, Adler SR. (2002) Superagonist estrogenic activity of resveratrol is related to cell density or growth effects. Endocrine Society - 84th Annual Meeting. Abstract P1-626.

    Google Scholar 

  164. Bartke A, Peluso MR, Moretz N, Wright C, Bonkowski M, Winters TA, Shanahan MF, Kopchick JJ, Banz WJ. (2004) Effects of soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long- lived and short lived mice. Horm Metab Res 36, 550–558.

    Article  PubMed  CAS  Google Scholar 

  165. Mueller SO, Simon S, Chae K, Metzler M, Korach KS. (2004) Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci 80, 14–25. Erratum in: Toxicol Sci 81, 530–1.

    Google Scholar 

  166. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M, Gannon F. (2003) Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115, 751–763.

    Article  PubMed  CAS  Google Scholar 

  167. DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M. (2000) BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors nvolved in histone acetylation. Mol Cell Biol 20, 7541–7549.

    Article  PubMed  CAS  Google Scholar 

  168. Sun JM, Chen HY, Davie JR. (2001) Effect of estradiol on histone acetylation dynamics in human breast cancer cells. J Biol Chem 276, 49435–49442.

    Article  PubMed  CAS  Google Scholar 

  169. Merchant JL, Bai L, Okada M. (2003) ZBP-89 mediates butyrate regulation of gene expression. J Nutr 133, 2456S–2460S.

    PubMed  CAS  Google Scholar 

  170. Bai L, Merchant JL. (2000) Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. J Biol Chem 275, 30725–30733.

    Article  PubMed  CAS  Google Scholar 

  171. Mariadason JM, Corner GA, Augenlicht LH. (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer Res 60, 4561–4572.

    PubMed  CAS  Google Scholar 

  172. Rocchi P, Tonelli R, Camerin C, Purgato S, Fronza R, Bianucci F, Guerra F, Pession A, Ferreri AM. (2005) p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells. Oncol Rep 13, 1139–1144.

    PubMed  CAS  Google Scholar 

  173. Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D. (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16, 93–105.

    Article  PubMed  CAS  Google Scholar 

  174. Shore D. (2000) The Sir2 protein family: a novel deacetylase for gene silencing and more. Proc Natl Acad Sci USA 97, 14030–14032.

    Article  PubMed  CAS  Google Scholar 

  175. Vaziri H, Dessain SK, ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. (2001) hSir2(SirT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149–159.

    Article  PubMed  CAS  Google Scholar 

  176. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. (2001) Negative control of p53 by Sir2 α promotes cell survival under stress. Cell 107, 137–148.

    Article  PubMed  CAS  Google Scholar 

  177. Lee TK, Man K, Poon RT, Lo CM, Ng IO, Fan ST. (2004) Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma. Oncol Rep 12, 25–31.

    PubMed  CAS  Google Scholar 

  178. Nemoto S, Fergusson MM, Finkel T. (2005) SirT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1 α . J Biol Chem 280( 16), 16456–16460 [Epub ahead of print, February 16].

    Article  PubMed  Google Scholar 

  179. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SirT1. Nature 434, 113–118.

    Article  PubMed  CAS  Google Scholar 

  180. Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. (2005) SirT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280, 10264–10276. Epub January 4.

    Article  PubMed  CAS  Google Scholar 

  181. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell S, Napper A, Curtis R, Distefano PS, Fields S, Bedalov A, Kennedy BK. (2005) Substrate specific activation of sirtuins by resveratrol. J Biol Chem 280( 17), 17038–17045 [Epub ahead of print, January 31].

    Article  PubMed  CAS  Google Scholar 

  182. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. (2005) SirT1 shows no substrate specificity in vitro. J Biol Chem 280, 9780–9785. Epub January 6.

    Article  PubMed  CAS  Google Scholar 

  183. Borra MT, Smith BC, Denu JM. (2005) Mechanism of human SirT1 activation by resveratrol. J Biol Chem 280( 17), 17187–17195 [Epub ahead of print, March 4].

    Article  PubMed  CAS  Google Scholar 

  184. Gehm BD, Levenson AS, Liu H, Lee EJ, Amundsen BM, Cushman M, Jordan VC, Jameson JL. (2004) Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. J Steroid Biochem Mol Biol 88, 223–234.

    Article  PubMed  CAS  Google Scholar 

  185. Hong T, Nakagawa T, Pan W, Kim MY, Kraus WL, Ikehara T, Yasui K, Aihara H, Takebe M, Muramatsu M, Ito T. (2004) Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Biochem Biophys Res Commun 317, 259–264.

    Article  PubMed  CAS  Google Scholar 

  186. Farhan H, Cross HS. (2002) Transcriptional inhibition of CYP24 by genistein. Ann N Y Acad Sci 973, 459–462.

    Article  PubMed  CAS  Google Scholar 

  187. Frey RS, Li J, Singletary KW. (2001) Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression. Biochem Pharmacol 61, 979–989.

    Article  PubMed  CAS  Google Scholar 

  188. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. (2005) Suppression of aging in mice by the hormone Klotho. Science 309, 1829–1833. Epub August 25.

    Article  PubMed  CAS  Google Scholar 

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Adler, S.R. (2007). Cellular Mechanisms of Endocrine Disruption. In: Gore, A.C. (eds) Endocrine-Disrupting Chemicals. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/1-59745-107-X_6

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