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The Pathology of Thyroid Cancer

  • Chapter
Molecular Basis of Thyroid Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 122))

Conclusion

Thyroid nodules are common and their management can be difficult and controversial. Clearly, the pathologist has an important role to play in their evaluation. The use of fine needle aspiration biopsy has significantly improved our ability to identify specific high risk disorders and to facilitate their management in an expeditious and cost-effective manner. Patients who require surgery for further confirmation of the disease process rely upon the pathologist to correctly characterize their nodule and pathologists are actively involved in research to clarify the pathogenesis of thyroid disease. There are other areas of thyroid pathology that have seen uniform advances in our understanding of the pathobiology of disease. Most experts accept tall cell or columnar morphology as predictive of more aggressive variants of papillary carcinoma. The recognition of insular carcinomas as an intermediate category of “poorly differentiated carcinoma” has been validated by clinical and molecular studies. The biology of familial genetic alterations in medullary carcinoma has revolutionised patient care. Advances in our understanding of the molecular basis of thyroid cancer will allow more accurate characterization of specific subtypes of neoplasia and malignancy even on single cells obtained at fine needle aspiration biopsy. This should further enhance the usefulness of this technique and better guide the management of patients with a thyroid nodule.

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Authors and Affiliations

  1. Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

    Sylvia L. Asa

  2. University Health Network and Toronto Medical Laboratories, Toronto, Ontario, Canada

    Sylvia L. Asa

  3. Freeman Centre for Endocrine Oncology, Mount Sinai & Princess Margaret Hospitals, Toronto, Ontario, Canada

    Sylvia L. Asa

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  1. Sylvia L. Asa
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  1. Osancor Biotech, Inc., Watford, WD17 3BY, Herts, UK

    Nadir R. Farid

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© 2005 Springer Science + Business Media, Inc.

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Asa, S.L. (2005). The Pathology of Thyroid Cancer. In: Farid, N.R. (eds) Molecular Basis of Thyroid Cancer. Cancer Treatment and Research, vol 122. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8107-3_2

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  • DOI: https://doi.org/10.1007/1-4020-8107-3_2

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