Designing Pediatric Formularies for Childhood Immunization Using Integer Programming Models

  • Sheldon H. Jacobson
  • Edward C. Sewell
Part of the International Series in Operations Research & Management Science book series (ISOR, volume 70)


Several challenges have arisen in childhood immunization programs as vaccine manufacturers have become more successful in developing new vaccines for childhood diseases. Their success has created a combinatorial explosion of choices for health-care providers and other purchasers of pediatric vaccines, which in turn has created a new set of economic problems and issues related to determining which vaccines should be combined into single injections and how to design lowest overall cost formularies for pediatric immunization. This chapter provides a review of how operations research modeling and analysis tools can be used to address a variety of economic issues surrounding pediatric vaccine formulary design and pricing. A summary is presented of the pediatric immunization problems that have been studied using integer programming models, as well as the assumptions used to model such problems. A description of the methodologies used is provided. A summary of the results obtained with these models for a particular pentavalent combination vaccine that recently gained Food and Drug Administration (FDA) approval for pediatric immunization is presented. Concluding comments and directions for future research are also discussed.

Key words

Pediatric immunization Combination vaccines Economics Integer programming models 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Sheldon H. Jacobson
    • 1
  • Edward C. Sewell
    • 2
  1. 1.Department of Mechanical and Industrial EngineeringUniversity of IllinoisUrbana
  2. 2.Department of Mathematics and StatisticsSouthern Illinois University EdwardsvilleEdwardsville

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