Abstract
Activation and augmentation of complement cascades are well-known functions of certain classes of immunoglobulins. On the other hand, pooled immunoglobulins in supraphysiologic concentrations have the ability to inhibit harmful biological effects of activated complement fragments by diverting them away from their targets to the fluid phase, where they may be subject to further inactivation. Scavenging appears to be mediated by immunoglobulin fragment-specific acceptor sites. Domains within constant region of F(ab)’2 seem responsible for anaphylatoxin binding and neutralization, while Fc fragments interact with C3b and C4b. The ability to attenuate complement fragment- induced immune damage cannot be correlated with any known phenotypic marker used today to categorize immunoglobulins and could serve as a basis for a new classification of immunoglobulinsstrong versus weak inhibitors of complement fragment effects. The concept of dual effect of immunoglobulins on the complement system has implications for both novel physiologic functions of normal circulating immunoglobulins as well as clinical applications of high-dose intravenous immunoglobulin (IVIG).
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Basta, M. (2004). Activation and Inhibition of Complement by Immunoglobulins. In: Szebeni, J. (eds) The Complement System. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8056-5_24
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DOI: https://doi.org/10.1007/1-4020-8056-5_24
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