Abstract
After a brief review of early experiments leading up to a multihit, or cumulative damage theory of immune hemolysis, the author describes the experiments by Mayer and associates that led to the development of the one hit theory. The author describes his personal experiences at and the workings of the Mayer laboratory at the Johns Hopkins School of Public Health and at the School of Medicine. He discusses the development of the mathematical theory by Rapp for the interaction of C2 with the cell intermediate EAC142 and describes experimental confirmation for the one hit theory of immune hemolysis. The author places these events in historical context of the development of modern concepts of complement action.
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Borsos, T. (2004). The Development of the “One-Hit” or “Single Site” Theory of Complement Mediated Immune Hemolysis. In: Szebeni, J. (eds) The Complement System. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8056-5_1
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DOI: https://doi.org/10.1007/1-4020-8056-5_1
Publisher Name: Springer, Boston, MA
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