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Somatostatin pp 65–80Cite as

Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice

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Part of the book series: Endocrine Updates ((ENDO,volume 24))

Summary

In summary, we have examined the physiological role of SST in the regulation of GH secretion by a gene knockout approach. The absence of SST results in elevated nadir and median GH levels in both sexes and a feminized pattern of GH-dependent gene expression in the liver of male mice. Despite the magnitude of these changes, SST−/− mice do not exhibit increased IGF-1 levels or gigantism and they retain a normal sexual dimorphism in postnatal somatic growth. A comparison of the distribution of a large set of randomly obtained GH values from mice in our study with GH data from formal pulse-analysis studies suggests that the pattern of GH secretion in both sexes of SST−/− mice is most similar to female rats. Measurement of pulsatile GH from cannulated SST-deficient mice will be necessary to confirm this hypothesis. We conclude that SST has an essential physiological role to determine the normal secretory profile of GH in both sexes of mice and specifically to masculinize GH secretion, however our data challenge the concept that a typical masculinized profile of GH pulsatility or masculinized liver is necessary for the greater somatic growth characteristics of male compared to female animals after puberty.

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Authors and Affiliations

  1. Vollum Institute, Oregon Health Sciences University, Portland, OR, 97201, USA

    Malcolm J. Low, Marcelo Rubinstein & Veronica Otero-Corchon

  2. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigacions Científicas y Técnicas and Departamento de Ciencias Biolégicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina

    Marcelo Rubinstein

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  1. Department of Medicine, McGill University Heath Center, Montréal, Québec, Canada

    Coimbatore B. Srikant

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Low, M.J., Rubinstein, M., Otero-Corchon, V. (2004). Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice. In: Srikant, C.B. (eds) Somatostatin. Endocrine Updates, vol 24. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8033-6_5

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