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The Role of Nitric Oxide in Heart Failure pp 81–92Cite as

Role of Nitric Oxide in the Pathophysiology of Heart Failure

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Abstract

Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal—NOS1, inducible—NOS2, and endothelial—NOS8) is imperative to comprehend derangements of the NO signaling pathway in the failing cardiovascular system. Several theories of NO and its regulation have developed as explanations for the divergent observations from studies in health and disease states. Here we review the physiologic and pathophysiologic influence of NO on cardiac function, in a framework that considers several theories of altered NO signaling in heart failure. We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA

    Hunter C. Champion, Michel W. Skaf & Joshua M. Hare

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  1. Hunter C. Champion
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  2. Michel W. Skaf
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  3. Joshua M. Hare
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  1. Cardiology Division Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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Champion, H.C., Skaf, M.W., Hare, J.M. (2004). Role of Nitric Oxide in the Pathophysiology of Heart Failure. In: Jugdutt, B.I. (eds) The Role of Nitric Oxide in Heart Failure. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7960-5_7

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  • DOI: https://doi.org/10.1007/1-4020-7960-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7736-4

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