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Peroxynitrite in Myocardial Ischemia-Reperfusion Injury

  • Chapter
The Role of Nitric Oxide in Heart Failure

Abstract

Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion. This review surveys evidence supporting both sides and proposes that peroxynitrite is a dichotomous molecule with beneficial and detrimental effects on the reperfused heart. Its toxic effects are mediated by modification and activation of a variety of targets (including poly (ADP) ribose synthetase and matrix metalloproteinases) while its beneficial effects are primarily mediated through its reaction with thiols, resulting in the formation of NO donor compounds (S-nitrosothiols).

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Authors and Affiliations

  1. Department of Pharmacology, Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada

    Manoj M. Lalu, Wenjie Wang & Richard Schulz

  2. Department of Pediatrics, Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada

    Richard Schulz

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  1. Manoj M. Lalu
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  2. Wenjie Wang
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  3. Richard Schulz
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Editors and Affiliations

  1. Cardiology Division Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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© 2004 Kluwer Academic Publishers

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Lalu, M.M., Wang, W., Schulz, R. (2004). Peroxynitrite in Myocardial Ischemia-Reperfusion Injury. In: Jugdutt, B.I. (eds) The Role of Nitric Oxide in Heart Failure. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7960-5_18

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  • DOI: https://doi.org/10.1007/1-4020-7960-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7736-4

  • Online ISBN: 978-1-4020-7960-3

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