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The Role of Nitric Oxide in Heart Failure pp 3–7Cite as

Nitric Oxide in Heart Failure: Friend or Foe

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Abstract

Nitric oxide (NO) is a controversial molecule. It is either beneficial or deleterious. As with NO donors, one reason for this duality is related to the dose. Small doses are highly beneficial, maintaining blood flow in vessels and blood pressure, and protecting against foreign invaders. In high doses, it results in hypotension, forms peroxynitrite which is cytotoxic, and contributes to heart failure.

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Author information

Authors and Affiliations

  1. 2C2.43 Walter Mackenzie Health Sciences Centre, Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada, T6G 2R7

    Dr. Bodh I. Jugdutt

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  1. Dr. Bodh I. Jugdutt
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Editors and Affiliations

  1. Cardiology Division Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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© 2004 Kluwer Academic Publishers

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Jugdutt, B.I. (2004). Nitric Oxide in Heart Failure: Friend or Foe. In: Jugdutt, B.I. (eds) The Role of Nitric Oxide in Heart Failure. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7960-5_1

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  • DOI: https://doi.org/10.1007/1-4020-7960-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7736-4

  • Online ISBN: 978-1-4020-7960-3

  • eBook Packages: Springer Book Archive

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