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Working Memory in Prefrontal Cortex and its Neuromodulation

  • Chapter
Prefrontal Cortex: From Synaptic Plasticity to Cognition

Abstract

Working memory is conceptually different from short-term memory and likely relies on different neurobiological substrates. Working memory may be defined as the capacity to use mnemonic information to plan and organize forthcoming action. These processes rely on the prefrontal cortex (PFC), and neurons in this region appear to encode mnemonic information and forthcoming responses based on memory. The task related activity of PFC neurons and overall working memory performance is strongly regulated by dopamine. Dopamine might bias networks of PFC neurons to enter different processing modes, causing PFC networks to either process memory related information in a flexible manner (state 1) or to strongly maintain a single goal state in memory even in the presence of distracters (state 2). Dopamine levels in PFC fluctuate during different cognitive and emotional states, and such fluctuations could switch PFC networks between these two states. Dopamine may therefore dynamically regulate how PFC networks “work with memory” to guide future thought or action.

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Authors and Affiliations

  1. Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC29425, USA

    Jeremy K. Seamans

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  1. Jeremy K. Seamans
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  1. Universite de Paris VI, Paris, France

    Satoru Otani

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© 2004 Kluwer Academic Publishers

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Seamans, J.K. (2004). Working Memory in Prefrontal Cortex and its Neuromodulation. In: Otani, S. (eds) Prefrontal Cortex: From Synaptic Plasticity to Cognition. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7949-4_2

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  • DOI: https://doi.org/10.1007/1-4020-7949-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7766-1

  • Online ISBN: 978-1-4020-7949-8

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