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Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells

  • Chapter
Hypoxic Pulmonary Vasoconstriction

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 252))

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Conclusion

Both acute and chronic hypoxia alter resting [Ca2+]i value and Ca2+ transients in PASMCs. These alterations are related to hypoxia-mediated effects on various pathways implicated in PASMC Ca2+ homeostasis: voltage-dependent and-independent Ca2+ influx, IP3R5Ca2+ re-uptake, etc. These alterations also play a role in both structural and reactivity changes of the pulmonary circulation in the course of the development of PAHT, as well as in its potential reversal upon normal air breathing. Further studies are therefore required to provide a comprehensive description of the variety of hypoxia-induced effects on calcium signaling in PASMCs, and to identify the common mechanism(s) leading to these various effects in order to define new molecular therapeutic targets.

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Authors and Affiliations

  1. Université V. Ségalen Bordeaux2, Bordeaux, France

    Jean-Pierre Savineau, Sébastien Bonnet & Roger Marthan

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  1. Jean-Pierre Savineau
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  2. Sébastien Bonnet
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Editors and Affiliations

  1. Department of Medicine, University of California, San Diego School of Medicine, San Diego, California

    Jason X. -J. Yuan M.D., Ph.D.

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© 2004 Kluwer Academic Publishers

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Savineau, JP., Bonnet, S., Marthan, R. (2004). Hypoxia-Mediated Regulation of Ca2+ Transients in Pulmonary Artery Smooth Muscle Cells. In: Yuan, J.X.J. (eds) Hypoxic Pulmonary Vasoconstriction. Developments in Cardiovascular Medicine, vol 252. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7858-7_5

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  • DOI: https://doi.org/10.1007/1-4020-7858-7_5

  • Publisher Name: Springer, Boston, MA

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