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Hypoxic Pulmonary Vasoconstriction pp 437–447Cite as

Hypoxia-sensitive Transcription Factors and Growth Factors

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 252))

Conclusion

The role of growth factors in HPH is an open book, with no ending in sight. As novel vascular growth factors are discovered, and as we learn more about their biological and pathobiological role, we add a new level of understanding in HPH. Undoubtedly, abnormal vascular cell growth is at the center of pulmonary vascular remodeling in pulmonary hypertension (Fig. 3). In the next few years, the elucidation of master control levels of pulmonary vascular remodeling using genomics and proteonomics of human lung tissue compromised by pulmonary hypertension and transgenic models of pulmonary hypertension may shed important information in the relative contribution of growth factor in the pathogenesis of HPH.

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Author information

Authors and Affiliations

  1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Ari L. Zaiman & Rubin M. Tuder

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  1. Ari L. Zaiman
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  2. Rubin M. Tuder
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Editors and Affiliations

  1. Department of Medicine, University of California, San Diego School of Medicine, San Diego, California

    Jason X. -J. Yuan M.D., Ph.D.

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© 2004 Kluwer Academic Publishers

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Zaiman, A.L., Tuder, R.M. (2004). Hypoxia-sensitive Transcription Factors and Growth Factors. In: Yuan, J.X.J. (eds) Hypoxic Pulmonary Vasoconstriction. Developments in Cardiovascular Medicine, vol 252. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7858-7_25

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  • DOI: https://doi.org/10.1007/1-4020-7858-7_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7857-6

  • Online ISBN: 978-1-4020-7858-3

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