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Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing

  • Chapter
Hypoxic Pulmonary Vasoconstriction

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 252))

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Conclusion

The concept of mitochondrial diversity in the vasculature is new and requires further study as it is likely relevant to other aspects of vascular function. In addition to its role in vascular O2-sensing the diversity concept may have implications for apoptosis, vascular wall remodeling or ischemia-reperfusion injury. It remains to be shown whether this mitochondrial diversity is due to a genetic difference intrinsic to the mitochondria or a result of the different redox environment that the PA are exposed to, compared to the RA.

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Authors and Affiliations

  1. University of Alberta, Edmonton, Canada

    Sean McMurtry & Evangelos D. Michelakis

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  1. Sean McMurtry
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  2. Evangelos D. Michelakis
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Editors and Affiliations

  1. Department of Medicine, University of California, San Diego School of Medicine, San Diego, California

    Jason X. -J. Yuan M.D., Ph.D.

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McMurtry, S., Michelakis, E.D. (2004). Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing. In: Yuan, J.X.J. (eds) Hypoxic Pulmonary Vasoconstriction. Developments in Cardiovascular Medicine, vol 252. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7858-7_17

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  • DOI: https://doi.org/10.1007/1-4020-7858-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7857-6

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