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Preoperative therapy for soft tissue sarcoma

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Book cover Targeting Treatment of Soft Tissue Sarcomas

Part of the book series: Cancer Treatment and Research ((CTAR,volume 120))

Conclusions

Soft tissue sarcomas continue to represent a therapeutic challenge because of their rarity and the heterogeneity of the many histologic subtypes. The efficacy of preoperative therapy has been difficult to establish. However, there is evidence that induction therapy may result in reduction of tumor size that facilitates less radical surgical resections with improved postoperative function. Clinical evidence supports continued investigation of preoperative treatment approaches for soft tissue sarcomas.

The use of preoperative therapy reinforces the need for cooperation among oncologic disciplines. The timing and sequence of treatment modalities should be discussed at the time of tumor diagnosis. Individual treatment decisions must weigh the estimated likelihood and severity of potential short- and long-term complications associated with one treatment sequence versus another.

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Authors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, TX, 77030-4009, USA

    Janice N. Cormier MD, MPH, Howard N. Langstein MD & Peter W. T. Pisters MD

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  1. Janice N. Cormier MD, MPH
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  2. Howard N. Langstein MD
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Editors and Affiliations

  1. Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Jaap Verweij

  2. Department of Medical Oncology, Free University Medical Center, Amsterdam, The Netherlands

    Herbert M. Pinedo

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Cormier, J.N., Langstein, H.N., Pisters, P.W.T. (2004). Preoperative therapy for soft tissue sarcoma. In: Verweij, J., Pinedo, H.M. (eds) Targeting Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 120. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7856-0_3

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