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Inflammation in the Pathogenesis of Chronic Diseases pp 31–62Cite as

Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus

Relationships to joint physiology, arthritis, and tissue repair

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 42))

Rheumatoid arthritis and osteoarthritis are painful and debilitating diseases with complex pathophysiology. There is growing evidence that pro-inflammatory cytokines (e.g., interleukin-1 and tumor necrosis factor alpha) and mediators (e.g., prostaglandins, leukotrienes, and nitric oxide) play critical roles in the development and perpetuation of tissue inflammation and damage in joint tissues such as articular cartilage and meniscus. While earlier studies have generally focused on cells of the synovium (especially macrophages), there is increasing evidence that chondrocytes and meniscal cells actively contribute to inflammatory processes. In particular, it is now apparent that mechanical forces engendered by joint loading are transduced to biological signals at the cellular level and that these signals modulate gene expression and biochemical processes. Here we give an overview of the interplay of cytokines and mechanical stress in the production of cyclooxygenases and prostaglandins; lipoxygenases and leukotrienes; and nitric oxide synthases and nitric oxide in arthritis, with particular focus on the interactions of these pathways in articular cartilage and meniscus

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology-Oncology, VA and Duke University Medical Centers, Durham, North Carolina

    Brice J. Weinberg

  2. Department of Surgery, Division of Orthopedics, Duke University Medical Center, Durham, North Carolina

    Beverley Fermor & Farshid Guilak

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  1. Brice J. Weinberg
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Editors and Affiliations

  1. Center of Molecular Epidemiology and Environmental Health, College of Medicine and School of Public Health, The Ohio State University Medical Center, Columbus, Ohio, USA

    Randall E. Harris (Director) (Director)

  2. Queens College, City University of New York, New York, USA

    R. Bittman

  3. Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  4. Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt

  5. MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  6. German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  7. Texas A&M University, Texas, USA

    A. Holzenburg

  8. National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  9. The Hebrew University, Jerusalem, Israel

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  10. DSM Nutritional Products Ltd., Basel, Switzerland

    M. Wyss

  11. Max-Planck-Institute for Biochemistry, Munich, Germany

    P. Zwickl

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Weinberg, B.J., Fermor, B., Guilak, F. (2007). Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus. In: Harris, R.E., et al. Inflammation in the Pathogenesis of Chronic Diseases. Subcellular Biochemistry, vol 42. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5688-5_2

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