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Nutritional Intervention in Brain Aging

Reducing the effects of inflammation and oxidative stress

  • Chapter
Inflammation in the Pathogenesis of Chronic Diseases

Part of the book series: Subcellular Biochemistry ((SCBI,volume 42))

It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0–14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging population, it is crucial to explore methods that may retard or reverse the deleterious effects of aging. Inflammation and oxidative stress play important roles in brain aging. Inflammatory markers, as well as cellular and molecular oxidative damage, increase during normal brain aging. This increase is accompanied by the concomitant decline in cognitive and motor performance in the elderly population, even in the absence of neurodegenerative diseases. Epidemiological studies have shown that consumption of diets rich in antioxidant and anti-inflammatory agents, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Research from our laboratory suggests that dietary supplementation with fruit or vegetable extracts can decrease the age-enhanced vulnerability to oxidative stress and inflammation. Additional research suggests that the polyphenolic compounds found in fruits such as blueberries may exert their beneficial effects through signal transduction and neuronal communication. Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases

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Authors and Affiliations

  1. USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA

    Francis C. Lau, Barbara Shukitt-Hale & James A. Joseph

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  1. Francis C. Lau
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  2. Barbara Shukitt-Hale
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  3. James A. Joseph
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Editor information

Editors and Affiliations

  1. Center of Molecular Epidemiology and Environmental Health, College of Medicine and School of Public Health, The Ohio State University Medical Center, Columbus, Ohio, USA

    Randall E. Harris (Director) (Director)

  2. Queens College, City University of New York, New York, USA

    R. Bittman

  3. Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  4. Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt

  5. MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  6. German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  7. Texas A&M University, Texas, USA

    A. Holzenburg

  8. National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  9. The Hebrew University, Jerusalem, Israel

    S. Rottem

  10. DSM Nutritional Products Ltd., Basel, Switzerland

    M. Wyss

  11. Max-Planck-Institute for Biochemistry, Munich, Germany

    P. Zwickl

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Lau, F.C., Shukitt-Hale, B., Joseph, J.A. (2007). Nutritional Intervention in Brain Aging. In: Harris, R.E., et al. Inflammation in the Pathogenesis of Chronic Diseases. Subcellular Biochemistry, vol 42. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5688-5_14

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