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Proprotein Convertases, Metalloproteases and Tumor Cell Invasion

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Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs)

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Abstract

The destruction of the basement membrane and extra-cellular matrix by various secreted proteinases from malignant and stromal cells is associated with tumor cell invasion and metastasis. The level of expression of these proteinases in tumor cells is associated with advanced-stage tumorigenesis and poor prognosis. Degradation of many extra-cellular matrix components, such as collagen, proteoglycan, fibronectin, vitronectin and laminin facilitate the detachment of tumor cells and their invasiveness. This complex process involves a cascade of proteolytic events in which the primary step likely implicates enzyme activation by the proprotein convertases (PCs). Of the metalloproteinases activated by the PCs of which the expression has been correlated with increased local aggressiveness, metastasis and poor clinical outcome are stromelysin-3 (str-3), membrane-type MMPs (MT-MMPs), the adamalysin metalloproteinases (ADAMs), and the adamalysin metalloproteinases with thrombospondin motifs (ADAM-TS). All these MMPs possess one or two typical recognition motif for furin-like enzymes and some of them were recently proven experimentally to be cleaved and activated by these enzymes. Thus, the blockade of the activation of these MMPs by PC inhibitors may provide a novel strategy in micrometastasis treatment and prevention

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  1. Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA

    Daniel E. Bassi & Andrès J.P. Klein-Szanto

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  1. Daniel E. Bassi
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  1. INSERM, Paris, France

    A-Majid Khatib

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Bassi, D.E., Klein-Szanto, A.J. (2006). Proprotein Convertases, Metalloproteases and Tumor Cell Invasion. In: Khatib, AM. (eds) Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs). Springer, Dordrecht. https://doi.org/10.1007/1-4020-5132-8_5

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