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Proprotein Convertases in Tumorigenesis, Angiogenesis and Metastasis

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Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs)

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Abstract

Proprotein convertases (PCs) are directly responsible for the activation of protein precursors implicated in neoplasia by either the degradation of extracellular matrix and modulation of cell adhesion, growth and/or survival. These functions are crucial in the acquisition of the tumorigenic phenotype, tumor progression and metastasis. Here we discuss a number of recent findings on the role of these enzymes in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells

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Authors and Affiliations

  1. INSERM U143, Le Kremlin-Bicêtre, France

    Geraldine Siegfried

  2. Regional Protein Chemistry Centre, Diseases of Ageing Unit, Ottawa Health Research Institute, Loeb Building, 725 Parkdale Ave., Ottawa, Ontario, Canada

    Michel Chrètien

  3. INSERM U 716/AVENIR., Institut de Gènètique Molèculaire, Laboratoire de Pharmacologie Expèrimentale et Clinique, Paris, France

    Abdel-Majid Khatib

Authors
  1. Geraldine Siegfried
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  2. Michel Chrètien
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  3. Abdel-Majid Khatib
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Editors and Affiliations

  1. INSERM, Paris, France

    A-Majid Khatib

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© 2006 Springer

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Siegfried, G., Chrètien, M., Khatib, AM. (2006). Proprotein Convertases in Tumorigenesis, Angiogenesis and Metastasis. In: Khatib, AM. (eds) Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs). Springer, Dordrecht. https://doi.org/10.1007/1-4020-5132-8_4

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